国产免疫治疗药卡瑞利珠单抗适应症和不良反应大盘点!

2022-04-30 网络 网络

卡瑞利珠单抗常见问题必须掌握!

卡瑞利珠单抗是本土企业恒瑞医药自主研发的PD-1免疫检查点抑制剂。作为国产免疫治疗药物,卡瑞利珠单抗上市较早,是继特瑞普利单抗和信迪利单抗之后的第三个国产PD-1抗癌药,这几年在临床使用广泛。

 

随着大量临床试验数据出炉,卡瑞利珠单抗在临床中的适应症范围逐渐增多。目前卡瑞利珠单抗已获批的8个适应症,涵盖5大类型恶性肿瘤。今天盘点卡瑞利珠单抗已获批的适应症、不良反应及处理措施。

 

一、卡瑞利珠单抗的八大适应症

 

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二、卡瑞利珠单抗不良反应及处理

 

1、反应性皮肤毛细血管增生症(RCCEP)

 

发生部位:主要发生于人体体表皮肤,大多见于头面部和躯干部;大多数呈孤立、散在性分布。
大体分型:按照外观形态,大致分为红痣型、珍珠型、桑椹型、斑片型、瘤样型;红痣型与珍珠型最多见。
 
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发生规律:
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RCCEP 分级标准:
 
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* 迄今为止未见引起内脏出血和 4-5 级 RCCEP 的情况。
RCCEP 的分级管理
 
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注意:
  • 大部分 RCCEP 可观察或对症处理,无需特殊治疗。

  • RCCEP 对激素不敏感,若结节较大且有破溃出血,可以局部应用云南白药粉、凝血酶冻干粉以及创可贴等止血,必要时外用抗生素预防感染;少数采取小手术切除或激光治疗。

  • 皮肤感染酌情积极给予局部或全身性抗生素治疗。

 

2、卡瑞利珠单抗不良反应汇总

 

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