J Rheumatol:系统性红斑狼疮男性患者中的无症状冠脉钙化

2018-03-28 xiangting MedSci原创

与年龄和性别相匹配的对照比较,SLE男性患者患冠脉钙化的风险升高。

这篇文章旨在探讨与年龄和性别相匹配的对照组比较,系统性红斑狼疮(SLE)男性患者的无症状性冠脉粥样硬化的发病率和程度是否升高,并确定其相关的危险因素。

采用多排螺旋CT对95例无冠脉病史的SLE患者(平均年龄34.7±10.1岁)和100例对照(年龄34.8±9.7岁)进行冠脉钙化筛查。使用Agatston评分衡量钙化程度。比较患者和对照之间钙化危险因素的频率,并研究临床免疫学特征与冠脉钙化之间的关系。

SLE患者冠脉钙化的频率高于对照组[分别为18%和7%(OR 2.89,95%CI 1.07-8.65)]。以下因素与钙化的存在独立相关:年龄(OR 1.12,95%CI 1.04-1.20),诊断为SLE(OR 3.38,95%CI 1.07-10.64),糖尿病(OR 6.88,95%CI 1.50-31.62),Framingham风险评分(OR 1.12,95%CI 1.00-1.23)和肾小球滤过率(OR 0.98,95%CI 0.96-1.00)。在SLE患者中,在诊断后的2.3年内,从32岁开始观察到冠脉钙化。年龄升高(OR 1.18,95%CI 1.06-1.31),系统性狼疮国际合作诊所评分(OR 2.85,95%CI 1.21-6.73)和泼尼松累积剂量(OR 1.04,95%CI 1.01-1.08)是独立危险因素。

与年龄和性别相匹配的对照比较,SLE男性患者患冠脉钙化的风险升高。在SLE患者中,风险升高与年龄较大,慢性损伤增加和糖皮质激素累积剂量相关。

原始出处:

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    2018-03-30 zhouqu_8
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    2018-03-28 happsf

    学习

    0

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