Stem cells：不同物种间的不相容性限制人类间充质干细胞在大鼠模型上发挥免疫调节作用

2018-05-07 MedSci MedSci原创

间充质干/祖细胞（MSC）是一种免疫调节细胞群，现有广泛的预临床和临床研究，研究其在炎症条件下（包括移植）的作用。近日，Stem cells上发表一篇文章，研究人员利用稳定建立的大鼠角膜移植模型，探究人MSC延长角膜同种异体移植无排斥反应存活期的能力。在角膜移植前先静脉输注人MSC（已用异体大鼠MSC证明可行）。出乎意外，预移植人MSC对角膜移植后的存活期没有影响。在体外，人MSC不能合成NO、上

间充质干/祖细胞（MSC）是一种免疫调节细胞群，现有广泛的预临床和临床研究，研究其在炎症条件下（包括移植）的作用。

近日，Stem cells上发表一篇文章，研究人员利用稳定建立的大鼠角膜移植模型，探究人MSC延长角膜同种异体移植无排斥反应存活期的能力。在角膜移植前先静脉输注人MSC（已用异体大鼠MSC证明可行）。

出乎意外，预移植人MSC对角膜移植后的存活期没有影响。在体外，人MSC不能合成NO、上调IDO，因而也不能抑制大鼠T细胞增殖。而且，人MSC不能被大鼠促炎性细胞因子激活。

因此，在细胞因子信号在物种间的不相容性导致了MSC植入失败，这或许可解释为什么人类MSC在大鼠同种异体移植模型组织中缺乏活体疗效。

解读临床移植试验的效果数据时，应考虑到不同物种间的不相容性。

原始出处：

Paul Lohan，et al.Inter‐Species Incompatibilities Limit the Immunomodulatory Effect of Human Mesenchymal Stromal Cells in the Rat. Stem cells.May 03，2018.https：//doi.org/10.1002/stem.2840

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2018-11-26 维他命

#CEL#

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2018-09-05 zhaozhouchifen

#Cell#

26 0
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2018-05-21 hb2008ye

#stem cell#

40 0
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2018-10-20 h.y200607_23674418

#间充质干细#

33 0
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2018-07-22 yykkxiaodou

#stem cells#

26 0
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2018-05-16 半夏微凉

学习了谢谢分享

99 0
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2018-05-09 12498bb3m92(暂无昵称)

#STEM#

29 0
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2018-05-09 124988c7m101暂无昵称

#cells#

22 0
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2018-05-07 易水河

免疫排斥啊!

88 0

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Stem cells：不同物种间的不相容性限制人类间充质干细胞在大鼠模型上发挥免疫调节作用

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