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Eur J Heart Fail：循环miR-32水平改善慢性心力衰竭患者心衰住院风险预测！

2018-02-11 xing.T MedSci原创

循环miR-32慢性心力衰竭心衰住院风险预测
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由此可见，在典型的慢性心衰患者中，循环miR-32水平升高与心衰的严重程度相关。低水平循环miR-32相比于传统的危险因素，可提高心衰再入院的风险预测，但不能提高对死亡的预测。miR-32可能有助于强化旨在减少再住院的策略。

非编码microRNA（microRNAs）在心血管病理生理学中发挥重要作用。因为它们在大多数体液中都是可测量的，所以常被用作循环生物标记物。近日，心血管领域权威杂志European Journal of Heart Failure上发表了一篇研究文章，在这个慢性心衰患者中进行的多中心临床试验中研究人员分析了特定候选miRNA的预后价值。

研究人员使用miRNA特异PCR技术检测了953例慢性有症状心衰患者血浆中miR-32水平。在校正模型中，研究人员估计了致命性（全因和心血管死亡）和非致命事件（心血管原因或心衰恶化的首次入院时间）与增量风险预测之间的相关性。

研究人员发现较高的循环miR-32水平与年龄较小的、肾过滤较好的、缺血性病因的HF、症状更严重HF、舒张压高、高胆固醇和男性独立相关。对人口统计学指标、临床和超声心动图危险因素、基线NT-proBNP浓度进行广泛的调整后，miR-132水平只与与心衰住院相关（风险比为0.79，95%可信区间为0.66-0.95，P=0.01），并可以改善其风险预测，连续净重新分类指数为0.205（P=0.001）。

由此可见，在典型的慢性心衰患者中，循环miR-32水平升高与心衰的严重程度相关。低水平循环miR-32相比于传统的危险因素，可提高心衰再入院的风险预测，但不能提高对死亡的预测。miR-32可能有助于强化旨在减少再住院的策略。

原始出处：

Serge Masson,et al. Circulating microRNA-132 levels improve risk prediction for heart failure hospitalization in patients with chronic heart failure. Eur J Heart Fail.2018. http://onlinelibrary.wiley.com/doi/10.1002/ejhf.961/full

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    2018-06-17 smallant2002

    #miR#

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    2018-12-27 ymljack

    #心衰住院#

    0

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    2018-02-15 jihuaijun1112

    学习学习学习

    0

  4. 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    2018-02-15 jihuaijun1112

    学习学习学习

    0

  5. 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    2018-02-13 jihuaijun1112

    学习学习学习

    0

  6. 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    2018-02-13 bluefate121

    #住院风险#

    0

  7. 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GetPortalCommentsPageByObjectIdResponse(id=1356694, encodeId=f4ce1356694f0, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Feb 13 11:43:00 CST 2018, time=2018-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1485947, encodeId=107e148594e2a, content=<a href='/topic/show?id=2c62100911a3' target=_blank style='color:#2F92EE;'>#风险预测#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100911, encryptionId=2c62100911a3, topicName=风险预测)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Tue Feb 13 11:43:00 CST 2018, time=2018-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562839, encodeId=0a761562839c4, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Tue Feb 13 11:43:00 CST 2018, time=2018-02-13, status=1, ipAttribution=)]
    2018-02-13 bioon1

    #慢性心力衰竭#

    0

  8. 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GetPortalCommentsPageByObjectIdResponse(id=1356694, encodeId=f4ce1356694f0, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Feb 13 11:43:00 CST 2018, time=2018-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1485947, encodeId=107e148594e2a, content=<a href='/topic/show?id=2c62100911a3' target=_blank style='color:#2F92EE;'>#风险预测#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100911, encryptionId=2c62100911a3, topicName=风险预测)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Tue Feb 13 11:43:00 CST 2018, time=2018-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562839, encodeId=0a761562839c4, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Tue Feb 13 11:43:00 CST 2018, time=2018-02-13, status=1, ipAttribution=)]
    2018-02-13 zhaojie88

    #ART#

    0

  9. 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createdName=智智灵药, createdTime=Tue Feb 13 11:43:00 CST 2018, time=2018-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562839, encodeId=0a761562839c4, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Tue Feb 13 11:43:00 CST 2018, time=2018-02-13, status=1, ipAttribution=)]
    2018-02-13 智智灵药

    #风险预测#

    0

  10. 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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Thu Feb 15 05:01:06 CST 2018, time=2018-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287711, encodeId=306128e711e0, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Tue Feb 13 22:40:02 CST 2018, time=2018-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251711, encodeId=12211251e118f, content=<a href='/topic/show?id=fab72646628' target=_blank 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createdName=智智灵药, createdTime=Tue Feb 13 11:43:00 CST 2018, time=2018-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562839, encodeId=0a761562839c4, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Tue Feb 13 11:43:00 CST 2018, time=2018-02-13, status=1, ipAttribution=)]
    2018-02-13 slcumt

    #HEART#

    0

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