JAHA:严重精神疾病患者心电图异常与致命性心血管疾病的关系

2021-01-12 MedSci原创 MedSci原创

与无精神疾病的对照者相比,ECG异常的SIM患者预后较差。ECG异常但无心血管疾病的SMI患者是高风险人群,他们可能从更好的监测和风险管理中获益。

一般人群中心电图异常与不良结局相关,但其在严重精神疾病(SMI)患者中的预后意义尚未明确。近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,与无精神疾病的对照者相比,研究人员旨在调查SMI患者无、轻微和重度心电图异常与致命性心血管疾病(CVD)之间的关系。

研究人员交叉连接了丹麦全国登记中心的数据,纳入了2001年至2015年期间有电子心电图数据的初级护理患者。如果患者在心电图记录前被诊断为精神分裂症、双相情感障碍或严重抑郁症,则归入SMI患者。对照者要求既往无任何精神疾病或精神药物使用史。研究人员采用伴有95%CI的风险比(HRs)和标准10年绝对风险来评估致命性CVD。

在346552名参与者中,10028名为SMI患者(3%;中位年龄为54岁;男性占45%)和336524名为对照者(97%;中位年龄为56岁;男性占48%)。研究人员观察到了SMI和心电图异常与致命性CVD之间存在相互作用(P<0.001)。与对照者相比,在无(HR为2.17;95%CI为1.95-2.43)、轻微(HR为1.90;95%CI为1.49-2.42)、重度(HR为1.40;95%CI为1.26-1.55) ECG异常个体中,严重精神疾病与致命性CVD相关。在不同年龄和性别亚组中,伴有ECG异常但基线时无心血管疾病的SMI患者发生致命性CVD的标准10年绝对风险最高。

由此可见,与无精神疾病的对照者相比,ECG异常的SIM患者预后较差。ECG异常但无心血管疾病的SMI患者是高风险人群,他们可能从更好的监测和风险管理中获益。

原始出处:

Christoffer Polcwiartek.et al.Association Between ECG Abnormalities and Fatal Cardiovascular Disease Among Patients With and Without Severe Mental Illness.J AM HEART ASSOC.2021.https://www.ahajournals.org/doi/full/10.1161/JAHA.120.019416

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    2021-01-14 zhaohui6731
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