Sleep:持续气道正压治疗6个月后,阻塞性睡眠呼吸暂停患者的认知功能明显改善

2022-07-13 MedSci原创 MedSci原创

在未经治疗的OSA中观察到的认知缺陷和脑电生理学的改变在6个月的治疗后是可逆的。

未经治疗的阻塞性睡眠呼吸暂停(OSA)患者往往报告有白天过度嗜睡和认知功能障碍的情况。为此,来自澳大利亚新南威尔士大学的学者评估了持续气道正压(CPAP)治疗对OSA患者睡眠脑电图(EEG)定量测量和认知功能的影响,结果发表在Sleep杂志上。

研究人员研究了167名OSA患者(年龄50±13,AHI 35.0±26.8),在使用CPAP之前和之后分别进行了检测。认知测试评估了工作记忆、持续注意力、视觉空间扫描和执行功能。所有参与者在基线和CPAP后都接受了夜间多导睡眠图。对90名参与者中的一个子集的脑电图数据(C3-M2)进行了功率谱分析。计算了NREM中的相对delta EEG功率和sigma功率以及REM中的EEG减速。还使用自动纺锤体事件检测得出N2中的纺锤体密度(事件/分钟)。所有的结果都以与基线相比的变化进行分析。

结果显示,使用CPAP 6个月后,所有认知领域的认知功能都得到了改善。在研究的子集中,6个月的治疗期后观察到NREM期间相对delta功率增加(p < .0001),sigma功率减少(p = .001)。总的来说,治疗后,N2期间的快速和慢速睡眠纺锤体密度增加。

综上,6个月的CPAP是的OSA患者认知表现得到改善,睡眠脑电图特征得到加强。这些发现表明,在未经治疗的OSA中观察到的认知缺陷和脑电生理学的改变在6个月的治疗后是可逆的。

 

参考文献:

Improvements in cognitive function and quantitative sleep electroencephalogram in obstructive sleep apnea after six months of continuous positive airway pressure treatment, Sleep, Volume 45, Issue 6, June 2022, zsac013。

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1989199, encodeId=170719891992e, content=<a href='/topic/show?id=246ee29858f' target=_blank style='color:#2F92EE;'>#睡眠呼吸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72985, encryptionId=246ee29858f, topicName=睡眠呼吸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3138208, createdName=zhanfl, createdTime=Tue Nov 08 14:03:31 CST 2022, time=2022-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2056432, encodeId=1f4320564324c, content=<a href='/topic/show?id=7c87638e776' target=_blank style='color:#2F92EE;'>#气道正压治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63877, encryptionId=7c87638e776, topicName=气道正压治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7770, createdName=jeanqiuqiu, createdTime=Mon Jul 25 01:03:31 CST 2022, time=2022-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1697015, encodeId=0756169e01532, content=<a href='/topic/show?id=d2e99e651e4' target=_blank style='color:#2F92EE;'>#阻塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97651, encryptionId=d2e99e651e4, topicName=阻塞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a23129903429, createdName=tomyang96, createdTime=Wed Nov 23 04:03:31 CST 2022, time=2022-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1345076, encodeId=df5113450e639, content=<a href='/topic/show?id=cf721640495' target=_blank style='color:#2F92EE;'>#SLE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16404, encryptionId=cf721640495, topicName=SLE)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/kbRUeosenzlejlNGWXdWjSYhBKL1QYGQwfehJOkMXHiavh5wl7pKeju5Kcxdvr50ic6FWML3x6NMCxhG1bOaVjyA/132, createdBy=20872500216, createdName=ms4657536712156177, createdTime=Fri Jul 15 05:03:31 CST 2022, time=2022-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596638, encodeId=aba01596638e9, content=<a href='/topic/show?id=70e4396491a' target=_blank style='color:#2F92EE;'>#呼吸暂停#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39649, encryptionId=70e4396491a, topicName=呼吸暂停)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e2a518392360, createdName=119337463, createdTime=Fri Jul 15 05:03:31 CST 2022, time=2022-07-15, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1989199, encodeId=170719891992e, content=<a href='/topic/show?id=246ee29858f' target=_blank style='color:#2F92EE;'>#睡眠呼吸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72985, encryptionId=246ee29858f, topicName=睡眠呼吸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3138208, createdName=zhanfl, createdTime=Tue Nov 08 14:03:31 CST 2022, time=2022-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2056432, encodeId=1f4320564324c, content=<a href='/topic/show?id=7c87638e776' target=_blank style='color:#2F92EE;'>#气道正压治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63877, encryptionId=7c87638e776, topicName=气道正压治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7770, createdName=jeanqiuqiu, createdTime=Mon Jul 25 01:03:31 CST 2022, time=2022-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1697015, encodeId=0756169e01532, content=<a href='/topic/show?id=d2e99e651e4' target=_blank style='color:#2F92EE;'>#阻塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97651, encryptionId=d2e99e651e4, topicName=阻塞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a23129903429, createdName=tomyang96, createdTime=Wed Nov 23 04:03:31 CST 2022, time=2022-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1345076, encodeId=df5113450e639, content=<a href='/topic/show?id=cf721640495' target=_blank style='color:#2F92EE;'>#SLE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16404, encryptionId=cf721640495, topicName=SLE)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/kbRUeosenzlejlNGWXdWjSYhBKL1QYGQwfehJOkMXHiavh5wl7pKeju5Kcxdvr50ic6FWML3x6NMCxhG1bOaVjyA/132, createdBy=20872500216, createdName=ms4657536712156177, createdTime=Fri Jul 15 05:03:31 CST 2022, time=2022-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596638, encodeId=aba01596638e9, content=<a href='/topic/show?id=70e4396491a' target=_blank style='color:#2F92EE;'>#呼吸暂停#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39649, encryptionId=70e4396491a, topicName=呼吸暂停)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e2a518392360, createdName=119337463, createdTime=Fri Jul 15 05:03:31 CST 2022, time=2022-07-15, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1989199, encodeId=170719891992e, content=<a href='/topic/show?id=246ee29858f' target=_blank style='color:#2F92EE;'>#睡眠呼吸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72985, encryptionId=246ee29858f, topicName=睡眠呼吸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3138208, createdName=zhanfl, createdTime=Tue Nov 08 14:03:31 CST 2022, time=2022-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2056432, encodeId=1f4320564324c, content=<a href='/topic/show?id=7c87638e776' target=_blank style='color:#2F92EE;'>#气道正压治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63877, encryptionId=7c87638e776, topicName=气道正压治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7770, createdName=jeanqiuqiu, createdTime=Mon Jul 25 01:03:31 CST 2022, time=2022-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1697015, encodeId=0756169e01532, content=<a href='/topic/show?id=d2e99e651e4' target=_blank style='color:#2F92EE;'>#阻塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97651, encryptionId=d2e99e651e4, topicName=阻塞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a23129903429, createdName=tomyang96, createdTime=Wed Nov 23 04:03:31 CST 2022, time=2022-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1345076, encodeId=df5113450e639, content=<a href='/topic/show?id=cf721640495' target=_blank style='color:#2F92EE;'>#SLE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16404, encryptionId=cf721640495, topicName=SLE)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/kbRUeosenzlejlNGWXdWjSYhBKL1QYGQwfehJOkMXHiavh5wl7pKeju5Kcxdvr50ic6FWML3x6NMCxhG1bOaVjyA/132, createdBy=20872500216, createdName=ms4657536712156177, createdTime=Fri Jul 15 05:03:31 CST 2022, time=2022-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596638, encodeId=aba01596638e9, content=<a href='/topic/show?id=70e4396491a' target=_blank style='color:#2F92EE;'>#呼吸暂停#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39649, encryptionId=70e4396491a, topicName=呼吸暂停)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e2a518392360, createdName=119337463, createdTime=Fri Jul 15 05:03:31 CST 2022, time=2022-07-15, status=1, ipAttribution=)]
    2022-11-23 tomyang96
  4. [GetPortalCommentsPageByObjectIdResponse(id=1989199, encodeId=170719891992e, content=<a href='/topic/show?id=246ee29858f' target=_blank style='color:#2F92EE;'>#睡眠呼吸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72985, encryptionId=246ee29858f, topicName=睡眠呼吸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3138208, createdName=zhanfl, createdTime=Tue Nov 08 14:03:31 CST 2022, time=2022-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2056432, encodeId=1f4320564324c, content=<a href='/topic/show?id=7c87638e776' target=_blank style='color:#2F92EE;'>#气道正压治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63877, encryptionId=7c87638e776, topicName=气道正压治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7770, createdName=jeanqiuqiu, createdTime=Mon Jul 25 01:03:31 CST 2022, time=2022-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1697015, encodeId=0756169e01532, content=<a href='/topic/show?id=d2e99e651e4' target=_blank style='color:#2F92EE;'>#阻塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97651, encryptionId=d2e99e651e4, topicName=阻塞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a23129903429, createdName=tomyang96, createdTime=Wed Nov 23 04:03:31 CST 2022, time=2022-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1345076, encodeId=df5113450e639, content=<a href='/topic/show?id=cf721640495' target=_blank style='color:#2F92EE;'>#SLE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16404, encryptionId=cf721640495, topicName=SLE)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/kbRUeosenzlejlNGWXdWjSYhBKL1QYGQwfehJOkMXHiavh5wl7pKeju5Kcxdvr50ic6FWML3x6NMCxhG1bOaVjyA/132, createdBy=20872500216, createdName=ms4657536712156177, createdTime=Fri Jul 15 05:03:31 CST 2022, time=2022-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596638, encodeId=aba01596638e9, content=<a href='/topic/show?id=70e4396491a' target=_blank style='color:#2F92EE;'>#呼吸暂停#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39649, encryptionId=70e4396491a, topicName=呼吸暂停)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e2a518392360, createdName=119337463, createdTime=Fri Jul 15 05:03:31 CST 2022, time=2022-07-15, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1989199, encodeId=170719891992e, content=<a href='/topic/show?id=246ee29858f' target=_blank style='color:#2F92EE;'>#睡眠呼吸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72985, encryptionId=246ee29858f, topicName=睡眠呼吸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3138208, createdName=zhanfl, createdTime=Tue Nov 08 14:03:31 CST 2022, time=2022-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2056432, encodeId=1f4320564324c, content=<a href='/topic/show?id=7c87638e776' target=_blank style='color:#2F92EE;'>#气道正压治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63877, encryptionId=7c87638e776, topicName=气道正压治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7770, createdName=jeanqiuqiu, createdTime=Mon Jul 25 01:03:31 CST 2022, time=2022-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1697015, encodeId=0756169e01532, content=<a href='/topic/show?id=d2e99e651e4' target=_blank style='color:#2F92EE;'>#阻塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97651, encryptionId=d2e99e651e4, topicName=阻塞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a23129903429, createdName=tomyang96, createdTime=Wed Nov 23 04:03:31 CST 2022, time=2022-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1345076, encodeId=df5113450e639, content=<a href='/topic/show?id=cf721640495' target=_blank style='color:#2F92EE;'>#SLE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16404, encryptionId=cf721640495, topicName=SLE)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/kbRUeosenzlejlNGWXdWjSYhBKL1QYGQwfehJOkMXHiavh5wl7pKeju5Kcxdvr50ic6FWML3x6NMCxhG1bOaVjyA/132, createdBy=20872500216, createdName=ms4657536712156177, createdTime=Fri Jul 15 05:03:31 CST 2022, time=2022-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596638, encodeId=aba01596638e9, content=<a href='/topic/show?id=70e4396491a' target=_blank style='color:#2F92EE;'>#呼吸暂停#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39649, encryptionId=70e4396491a, topicName=呼吸暂停)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e2a518392360, createdName=119337463, createdTime=Fri Jul 15 05:03:31 CST 2022, time=2022-07-15, status=1, ipAttribution=)]

相关资讯

Sleep and Breathing:未合并心血管疾病的轻度阻塞性睡眠呼吸暂停患者心脏影像学改变,OSA相关心血管疾病的一级预防不可忽视

近期,广东省人民医院呼吸科睡眠障碍中心主任医师欧琼专家团队在Sleep and Breathing发表,题为“Cardiac imageology changes in patients

2012年OSAHS相关性高血压诊治共识

     李南方 教授     第二届中国高血压大会暨中国医师协会高血压专业委员会年会于3月16~18日在北京国际会议中心举行,新疆维吾尔自治区人民医院副院长、新疆高血压研究所所长李南方教授介绍了《阻塞性睡眠呼吸暂停相关性高血压临床诊断和治疗专家共识》。该共识由中国医师协会高血压专业委员会、中华医学会呼吸医学分会睡眠呼吸疾病学组联合制定。   许多高血压患者合并有睡眠呼吸暂停低通气综合征(S

入睡打鼾,夜间憋气伴呼吸暂停——阻塞性睡眠呼吸暂停低通气综合征1例

  病史   患儿女性,4岁6个月,主因“入睡打鼾、张口呼吸2年,加重3个月”入院。 入院前2年,患儿在呼吸道感染后出现入睡打鼾,偶有张口呼吸。患儿易患呼吸道感染,5~6次/年,症状为流涕、鼻堵、咳嗽等,每当呼吸道感染时打鼾症状加重,治疗上呼吸道感染后打鼾略有好转。入院前3个月,患儿在上呼吸道感染后入睡打鼾加重,夜间憋气明显,反复出现呼吸暂停。当地医院拍鼻咽侧位片示:腺样体

儿童阻塞性睡眠呼吸暂停低通气综合征与变应性鼻炎

阻塞性睡眠呼吸暂停低通气综合征(OSAHS)是一种儿童常见疾病,且与变应性鼻炎(AR) 关系密切。

拓展阅读

CGP指南|《成年人阻塞性睡眠呼吸暂停低通气综合征筛查:美国预防临床服务指南工作组推荐声明》解读

本文将解读最新推荐,结合我国实际情况,为我国成年人OSAHS筛查提供参考。

Sleep and Breathing:未合并心血管疾病的轻度阻塞性睡眠呼吸暂停患者心脏影像学改变,OSA相关心血管疾病的一级预防不可忽视

近期,广东省人民医院呼吸科睡眠障碍中心主任医师欧琼专家团队在Sleep and Breathing发表,题为“Cardiac imageology changes in patients

儿童阻塞性睡眠呼吸暂停低通气综合征与变应性鼻炎

阻塞性睡眠呼吸暂停低通气综合征(OSAHS)是一种儿童常见疾病,且与变应性鼻炎(AR) 关系密切。

入睡打鼾,夜间憋气伴呼吸暂停——阻塞性睡眠呼吸暂停低通气综合征1例

  病史   患儿女性,4岁6个月,主因“入睡打鼾、张口呼吸2年,加重3个月”入院。 入院前2年,患儿在呼吸道感染后出现入睡打鼾,偶有张口呼吸。患儿易患呼吸道感染,5~6次/年,症状为流涕、鼻堵、咳嗽等,每当呼吸道感染时打鼾症状加重,治疗上呼吸道感染后打鼾略有好转。入院前3个月,患儿在上呼吸道感染后入睡打鼾加重,夜间憋气明显,反复出现呼吸暂停。当地医院拍鼻咽侧位片示:腺样体

2012年OSAHS相关性高血压诊治共识

     李南方 教授     第二届中国高血压大会暨中国医师协会高血压专业委员会年会于3月16~18日在北京国际会议中心举行,新疆维吾尔自治区人民医院副院长、新疆高血压研究所所长李南方教授介绍了《阻塞性睡眠呼吸暂停相关性高血压临床诊断和治疗专家共识》。该共识由中国医师协会高血压专业委员会、中华医学会呼吸医学分会睡眠呼吸疾病学组联合制定。   许多高血压患者合并有睡眠呼吸暂停低通气综合征(S