Sleep:持续气道正压治疗6个月后,阻塞性睡眠呼吸暂停患者的认知功能明显改善

2022-07-13 MedSci原创 MedSci原创

在未经治疗的OSA中观察到的认知缺陷和脑电生理学的改变在6个月的治疗后是可逆的。

未经治疗的阻塞性睡眠呼吸暂停(OSA)患者往往报告有白天过度嗜睡和认知功能障碍的情况。为此,来自澳大利亚新南威尔士大学的学者评估了持续气道正压(CPAP)治疗对OSA患者睡眠脑电图(EEG)定量测量和认知功能的影响,结果发表在Sleep杂志上。

研究人员研究了167名OSA患者(年龄50±13,AHI 35.0±26.8),在使用CPAP之前和之后分别进行了检测。认知测试评估了工作记忆、持续注意力、视觉空间扫描和执行功能。所有参与者在基线和CPAP后都接受了夜间多导睡眠图。对90名参与者中的一个子集的脑电图数据(C3-M2)进行了功率谱分析。计算了NREM中的相对delta EEG功率和sigma功率以及REM中的EEG减速。还使用自动纺锤体事件检测得出N2中的纺锤体密度(事件/分钟)。所有的结果都以与基线相比的变化进行分析。

结果显示,使用CPAP 6个月后,所有认知领域的认知功能都得到了改善。在研究的子集中,6个月的治疗期后观察到NREM期间相对delta功率增加(p < .0001),sigma功率减少(p = .001)。总的来说,治疗后,N2期间的快速和慢速睡眠纺锤体密度增加。

综上,6个月的CPAP是的OSA患者认知表现得到改善,睡眠脑电图特征得到加强。这些发现表明,在未经治疗的OSA中观察到的认知缺陷和脑电生理学的改变在6个月的治疗后是可逆的。

 

参考文献:

Improvements in cognitive function and quantitative sleep electroencephalogram in obstructive sleep apnea after six months of continuous positive airway pressure treatment, Sleep, Volume 45, Issue 6, June 2022, zsac013。

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    2022-11-23 tomyang96
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