Breast Cancer Research:女儿患乳腺癌的风险受父亲进食的脂肪种类影响

2016-07-27 MedSci MedSci原创

圣保罗大学的Thomas Ong博士发现,雄性小鼠若进食大量植物油食物,则雌性后代患乳腺癌的风险降低。研究结果发表在Breast Cancer Research。研究人员指出,如果他们的结果通过人体试验得以证实,那么纠正父亲饮食观念可能是一种降低女性患乳腺癌发病率的新的干预措施。 在美国,乳腺癌是女性最常见的第二大癌症,约1/8的女性会罹患该病。女性患乳腺癌的风险受到很多因素的影响,如疾病家族史和

圣保罗大学的Thomas Ong博士发现,雄性小鼠若进食大量植物油食物,则雌性后代患乳腺癌的风险降低。研究结果发表在Breast Cancer Research。研究人员指出如果他们的结果通过人体试验得以证实那么纠正父亲饮食观念可能是一种降低女性后代乳腺癌发病率的新的干预措施。

在美国,乳腺癌是女性最常见的第二大癌症约1/8的女性会罹患该病。女性患乳腺癌的风险受很多因素的影响如疾病家族史和遗传性基因突变等。越来越多的研究人员发现父亲的身体健康状况和生活方式可能对后代患乳腺癌风险有所影响。 

Ong博士和同事通过进行研究发现,父亲的饮食方式可能影响女性后代患乳腺癌的风险。

研究人员将60只雄性老鼠平均分为2组,实验组小鼠饲喂猪油或玉米油等高脂肪饮食脂肪含量约占60%对照组饲喂的饮食中脂肪含量约为16%。研究人员指出玉米油富含ω- 6系列多不饱和脂肪酸而猪油则含有较高含量的饱和脂肪。接下来研究人员令雄性小鼠与饲喂正常食物的雌性小鼠交配。小鼠的雌性后代也吃普通食物50天成熟后研究人员启动其中乳腺肿瘤的生长程序。研究人员评估雌性小鼠后代的肿瘤患病率、肿瘤出现时间、数量、体积等信息并进行分析。 

相比对照组的雌性小鼠后代而言,进食玉米油的雄性小鼠的后代中,雌性小鼠体内的肿瘤细胞生长缓慢,肿瘤细胞更少,也就是说雌性小鼠需要更长的时间启动肿瘤生长。 

因此,研究人员指出,父亲进食脂肪种类可影响女儿患乳腺癌的风险,多摄入植物油食物可降低女儿患乳腺癌的风险。研究人员表示仍需进行更进一步的研究以探究父亲的进食种类对女儿乳腺组织发育的影响。

原始出处:

[1] Breast cancer risk may be influenced by type of fat dad eats. MNT.2016 Jul 26.

[2] Thomas Ong,et al. Paternal programming of breast cancer risk in daughters in a rat model: opposing effects of animal- and plant-based high-fat diets. Breast Cancer Research. 2016 July 25.

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1710891, encodeId=9f401e1089193, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Wed Aug 24 03:56:00 CST 2016, time=2016-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=119521, encodeId=33451195219c, content=好文章,百姓也能从中学到好多医学知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sat Sep 10 16:58:00 CST 2016, time=2016-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=98246, encodeId=5d4c98246b0, content=有趣, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160812/IMG57AD9E92D552A2087.jpg, createdBy=a35f100635, createdName=sophiahuang, createdTime=Sat Aug 13 17:50:00 CST 2016, time=2016-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351086, encodeId=4dbb135108686, content=<a href='/topic/show?id=12e43e1263' target=_blank style='color:#2F92EE;'>#Breast#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3712, encryptionId=12e43e1263, topicName=Breast)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Jul 29 11:56:00 CST 2016, time=2016-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1557746, encodeId=475b155e7467a, content=<a href='/topic/show?id=d2601533982' target=_blank style='color:#2F92EE;'>#Research#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15339, encryptionId=d2601533982, topicName=Research)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96ab14929432, createdName=yangshch, createdTime=Fri Jul 29 11:56:00 CST 2016, time=2016-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1585114, encodeId=20d9158511412, content=<a href='/topic/show?id=625c9440e39' target=_blank style='color:#2F92EE;'>#进食#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94407, encryptionId=625c9440e39, topicName=进食)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=94cc17130334, createdName=gj0737, createdTime=Fri Jul 29 11:56:00 CST 2016, time=2016-07-29, status=1, ipAttribution=)]
    2016-09-10 1e10c84am36(暂无匿称)

    好文章,百姓也能从中学到好多医学知识

    0

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    2016-08-13 sophiahuang

    有趣

    0

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    2016-07-29 zhaojie88
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    2016-07-29 yangshch
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    2016-07-29 gj0737

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