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Diabetologia：主动脉僵硬度和动态血压可作为糖尿病肾病的预测指标？

2018-04-24 MedSci MedSci原创

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糖尿病肾病（DKD）是与血糖和血压控制不良相关的微血管并发症。近日，国际杂志 《Diabetologia》上在线发表一项关于主动脉僵硬度和动态血压作为糖尿病肾病的预测指标的来自里约热内卢2型糖尿病队列研究的竞争风险分析的研究。研究人员旨在评估DKD在2型糖尿病高危人群中的发展和进展的预测因子，重点聚焦在动态血压和动脉僵硬度上。 在一项前瞻性研究中，对未发生晚期肾功能衰竭的629名患者的随访

糖尿病肾病（DKD）是与血糖和血压控制不良相关的微血管并发症。近日，国际杂志 《Diabetologia》上在线发表一项关于主动脉僵硬度和动态血压作为糖尿病肾病的预测指标的来自里约热内卢2型糖尿病队列研究的竞争风险分析的研究。研究人员旨在评估DKD在2型糖尿病高危人群中的发展和进展的预测因子，重点聚焦在动态血压和动脉僵硬度上。 在一项前瞻性研究中，对未发生晚期肾功能衰竭的629名患者的随访中位时间为7.8年，每年评估其肾功能。监测动态血压，根据颈动脉-股骨脉搏波速度评估主动脉僵硬度。采用精细和灰色方法的多因素竞争风险分析全因死亡率，用于研究DKD的发生和进展、异常蛋白尿发展或进展或肾功能恶化（血清肌酸酐加倍或进展至终末期肾病）的独立预测因子。 研究发现，在基线时，有197个人患有DKD。随访期间，195名患者中DKD发生或进展，125名患者异常白蛋白尿发生或发展，91名患者肾功能恶化。校正基线白蛋白尿和肾功能，年龄，性别，糖尿病持续时间和肾素-血管紧张素拮抗剂后，发现血糖控制较差（HR 1.17,95％CI 0.98,1.40；第一年平均HbA 1c每增加一个SD增量，p=0.09 ）

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    2018-11-23 ms9608593228839890

    #DIA#

    0

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    2018-12-14 仁心济世

    #主动脉僵硬度#

    0

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    2018-04-26 哈夫

    没看明白?

    0

  4. 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time=2018-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546805, encodeId=50991546805e5, content=<a href='/topic/show?id=96a0332168b' target=_blank style='color:#2F92EE;'>#动脉僵硬度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33216, encryptionId=96a0332168b, topicName=动脉僵硬度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eb8013942519, createdName=1696533704_45270458, createdTime=Thu Apr 26 06:32:00 CST 2018, time=2018-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1760662, encodeId=bd531e6066273, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Tue Aug 28 22:32:00 CST 2018, time=2018-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308901, encodeId=3549308901b2, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Tue Apr 24 18:35:44 CST 2018, time=2018-04-24, status=1, ipAttribution=)]
    2018-04-26 anminleiryan

    #预测指标#

    0

  5. 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time=2018-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546805, encodeId=50991546805e5, content=<a href='/topic/show?id=96a0332168b' target=_blank style='color:#2F92EE;'>#动脉僵硬度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33216, encryptionId=96a0332168b, topicName=动脉僵硬度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eb8013942519, createdName=1696533704_45270458, createdTime=Thu Apr 26 06:32:00 CST 2018, time=2018-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1760662, encodeId=bd531e6066273, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, 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    2018-04-26 circumcision

    #主动脉#

    0

  6. 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time=2018-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546805, encodeId=50991546805e5, content=<a href='/topic/show?id=96a0332168b' target=_blank style='color:#2F92EE;'>#动脉僵硬度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33216, encryptionId=96a0332168b, topicName=动脉僵硬度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eb8013942519, createdName=1696533704_45270458, createdTime=Thu Apr 26 06:32:00 CST 2018, time=2018-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1760662, encodeId=bd531e6066273, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Tue Aug 28 22:32:00 CST 2018, time=2018-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308901, encodeId=3549308901b2, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Tue Apr 24 18:35:44 CST 2018, time=2018-04-24, status=1, ipAttribution=)]
    2018-04-26 limedical1977

    #动态血压#

    0

  7. 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time=2018-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546805, encodeId=50991546805e5, content=<a href='/topic/show?id=96a0332168b' target=_blank style='color:#2F92EE;'>#动脉僵硬度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33216, encryptionId=96a0332168b, topicName=动脉僵硬度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eb8013942519, createdName=1696533704_45270458, createdTime=Thu Apr 26 06:32:00 CST 2018, time=2018-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1760662, encodeId=bd531e6066273, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Tue Aug 28 22:32:00 CST 2018, time=2018-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308901, encodeId=3549308901b2, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Tue Apr 24 18:35:44 CST 2018, time=2018-04-24, status=1, ipAttribution=)]
    2018-04-26 dlwang_26703131

    #动脉僵硬#

    0

  8. 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time=2018-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546805, encodeId=50991546805e5, content=<a href='/topic/show?id=96a0332168b' target=_blank style='color:#2F92EE;'>#动脉僵硬度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33216, encryptionId=96a0332168b, topicName=动脉僵硬度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eb8013942519, createdName=1696533704_45270458, createdTime=Thu Apr 26 06:32:00 CST 2018, time=2018-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1760662, encodeId=bd531e6066273, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Tue Aug 28 22:32:00 CST 2018, time=2018-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308901, encodeId=3549308901b2, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Tue Apr 24 18:35:44 CST 2018, time=2018-04-24, status=1, ipAttribution=)]
    2018-04-26 1696533704_45270458

    #动脉僵硬度#

    0

  9. 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time=2018-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546805, encodeId=50991546805e5, content=<a href='/topic/show?id=96a0332168b' target=_blank style='color:#2F92EE;'>#动脉僵硬度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33216, encryptionId=96a0332168b, topicName=动脉僵硬度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eb8013942519, createdName=1696533704_45270458, createdTime=Thu Apr 26 06:32:00 CST 2018, time=2018-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1760662, encodeId=bd531e6066273, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Tue Aug 28 22:32:00 CST 2018, time=2018-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308901, encodeId=3549308901b2, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Tue Apr 24 18:35:44 CST 2018, time=2018-04-24, status=1, ipAttribution=)]
    2018-08-28 ms5439512287675881

    #BET#

    0

  10. 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authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Tue Aug 28 22:32:00 CST 2018, time=2018-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308901, encodeId=3549308901b2, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Tue Apr 24 18:35:44 CST 2018, time=2018-04-24, status=1, ipAttribution=)]
    2018-04-24 清风拂面

    谢谢分享学习

    0

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