Crit Care:危重患者是否需要补充肠外营养?

2017-06-11 MedSci MedSci原创

营养指南建议不同于肠外营养(PN)的使用,近期的相关观察数据显示,在重症监护病房(ICU)中,早期接受能量/蛋白质的量可以影响患者的死亡率,特别是体重指数(BMI)<25或> 35的营养摄入不足的患者。近期,一项发表在杂志Crit Care上的研究评估了与常规护理(单独使用EN)相比,通过补充PN(SPN)+肠内营养(EN)增加营养供应是否能够改善体重不足和肥胖的ICU患者的60天生存

营养指南建议不同于肠外营养(PN)的使用,近期的相关观察数据显示,在重症监护病房(ICU)中,早期接受能量/蛋白质的量可以影响患者的死亡率,特别是体重指数(BMI)<25或> 35的营养摄入不足的患者。

近期,一项发表在杂志Crit Care上的研究评估了与常规护理(单独使用EN)相比,通过补充PN(SPN)+肠内营养(EN)增加营养供应是否能够改善体重不足和肥胖的ICU患者的60天生存期和生活质量(QoL)。

此项为多中心随机对照试验,在四个国家的11个中心完成,成人ICU急性呼吸衰竭患者预期需要机械通气> 72小时,BMI <25或≥35的患者被随机分配以单独接受EN或SPN + EN组并在随机分组后7天达到规定营养目标的100%。

此项研究共纳入125例患者。在前7个随机化ICU中,SPN + EN患者的卡路里热量和蛋白质增加了26%,而单独EN组的患者增加了22%(均P <0.001)。外科ICU患者接受EN营养输送较差,并且与ICU患者相比,在接受SPN时卡路里和蛋白质的营养显着增加。在此项试验中,组间无明显差异,无感染风险差异。此外,还观察到SPN + EN组与EN单独组相比,尽管潜在的统计学意义不大,但是,其降低了住院死亡率和改善患者的功能以及QoL结局。

此项研究表明:在ICU住院的第一周提供SPN + EN与单独EN相比,可以显着增加卡路里/蛋白质的补给,并且其没有增加感染风险。

原始出处:
Wischmeyer PE, Hasselmann M, et al. A randomized trial of supplemental parenteral nutrition in underweight and overweight critically ill patients: the TOP-UP pilot trial. Crit Care. 2017 Jun 9;21(1):142. doi: 10.1186/s13054-017-1736-8.

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    2017-06-12 明天会更好!

    感谢分享!继续关注!

    0

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    2017-06-12 1dd7a091m35(暂无匿称)

    学习了,谢谢,。。。。

    0

  4. 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    2017-06-12 惠映实验室

    应该是要,学习了

    0

  5. 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    2017-06-12 184****9840

    学习了谢谢分享。

    0

  6. 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    2017-06-12 微笑人参

    最原始的通道,就是最科学的原因。

    0

  7. 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createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Mon Jun 12 08:00:35 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209688, encodeId=80122096882c, content=学习了谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=d41c2055892, createdName=184****9840, createdTime=Mon Jun 12 07:13:09 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209645, encodeId=694520964563, content=最原始的通道,就是最科学的原因。, beContent=null, objectType=article, channel=null, level=null, 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    2017-06-12 微笑人参

    有生命就需要营养

    0

  8. 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    2017-06-12 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

    0

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    2017-06-12 lou.minghong

    学习

    0

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    2017-06-11 清风拂面

    谢谢分享,学习了

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