Neurologia:牙周炎和老年痴呆症的发生之间呈正相关

2016-10-27 MedSci MedSci原创

牙周病和老年痴呆症是非常普遍的,尤其是在老年人群中。多个研究表明牙周炎和老年痴呆症之间具有关联,但是,这些研究的异质性较大,由此可能会影响对二者关联机制的理解以及结果的对比。本文旨在对二者关联的研究做一系统回顾.研究人员共检索了22项研究,其中大部分为回顾性研究。分析各种方法学变量,包括研究人群,牙周炎的诊断,老年痴呆症的定义,校正后的变量,以及结果。可能影响这两种疾病进展和相互作用的不同致病原机

牙周病和老年痴呆症是非常普遍的,尤其是在老年人群中。多个研究表明牙周炎和老年痴呆症之间具有关联,但是,这些研究的异质性较大,由此可能会影响对二者关联机制的理解以及结果的对比。本文旨在对二者关联的研究做一系统回顾.

研究人员共检索了22项研究,其中大部分为回顾性研究。分析各种方法学变量,包括研究人群,牙周炎的诊断,老年痴呆症的定义,校正后的变量,以及结果。可能影响这两种疾病进展和相互作用的不同致病原机制也进行了分析。

虽然现有的证据表明,牙周炎和老年痴呆症之间呈正相关关系,但是二者关联的强度以及二者之间是否存在因果关系则尚未确定。

原始出处:

Pazos P, Leira Y, Domínguez C, Pías-Peleteiro JM, Blanco J, Aldrey JM. Association between periodontal disease and dementia: A literature review. Neurologia. 2016 Oct 22. pii: S0213-4853(16)30178-5. doi: 10.1016/j.nrl.2016.07.013.

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    2017-08-08 yinhl1978
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    2017-04-03 Boyinsh
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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Mon Dec 12 09:10:39 CST 2016, time=2016-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154392, encodeId=7e9d1543921e, content=拜读了,受益匪浅,点个赞!继续关注学习。认真探究、学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Nov 08 20:25:56 CST 2016, time=2016-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450486, encodeId=646e14504864f, content=<a href='/topic/show?id=f0476e49582' target=_blank 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likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Fri Oct 28 06:25:59 CST 2016, time=2016-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=151582, encodeId=35a6151582e4, content=真的吗?保护好我们的牙齿, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87421705485, createdName=1de8ed50m80(暂无匿称), createdTime=Thu Oct 27 20:17:49 CST 2016, time=2016-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=151581, encodeId=71af15158109, content=好好保护牙齿, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0f261920920, createdName=上邪zyy, createdTime=Thu Oct 27 20:16:27 CST 2016, time=2016-10-27, status=1, ipAttribution=)]
    2016-12-12 1e10c84am36(暂无匿称)

    牙周炎危害太多太大

    0

  5. 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style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Sat Oct 29 10:51:00 CST 2016, time=2016-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=151680, encodeId=5099151680be, content=不错不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0f261920920, createdName=上邪zyy, createdTime=Fri Oct 28 11:17:19 CST 2016, time=2016-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=151627, encodeId=721315162ead, content=学习了,继续关注!, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Fri Oct 28 06:25:59 CST 2016, time=2016-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=151582, encodeId=35a6151582e4, content=真的吗?保护好我们的牙齿, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87421705485, createdName=1de8ed50m80(暂无匿称), createdTime=Thu Oct 27 20:17:49 CST 2016, time=2016-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=151581, encodeId=71af15158109, content=好好保护牙齿, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0f261920920, createdName=上邪zyy, createdTime=Thu Oct 27 20:16:27 CST 2016, time=2016-10-27, status=1, ipAttribution=)]
    2016-11-08 ylzr123

    拜读了,受益匪浅,点个赞!继续关注学习。认真探究、学习。

    0

  6. 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style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Sat Oct 29 10:51:00 CST 2016, time=2016-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=151680, encodeId=5099151680be, content=不错不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0f261920920, createdName=上邪zyy, createdTime=Fri Oct 28 11:17:19 CST 2016, time=2016-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=151627, encodeId=721315162ead, content=学习了,继续关注!, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Fri Oct 28 06:25:59 CST 2016, time=2016-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=151582, encodeId=35a6151582e4, content=真的吗?保护好我们的牙齿, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87421705485, createdName=1de8ed50m80(暂无匿称), createdTime=Thu Oct 27 20:17:49 CST 2016, time=2016-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=151581, encodeId=71af15158109, content=好好保护牙齿, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0f261920920, createdName=上邪zyy, createdTime=Thu Oct 27 20:16:27 CST 2016, time=2016-10-27, status=1, ipAttribution=)]
  7. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0f261920920, createdName=上邪zyy, createdTime=Thu Oct 27 20:16:27 CST 2016, time=2016-10-27, status=1, ipAttribution=)]
    2016-10-28 上邪zyy

    不错不错

    0

  8. 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likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Fri Oct 28 06:25:59 CST 2016, time=2016-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=151582, encodeId=35a6151582e4, content=真的吗?保护好我们的牙齿, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87421705485, createdName=1de8ed50m80(暂无匿称), createdTime=Thu Oct 27 20:17:49 CST 2016, time=2016-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=151581, encodeId=71af15158109, content=好好保护牙齿, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0f261920920, createdName=上邪zyy, createdTime=Thu Oct 27 20:16:27 CST 2016, time=2016-10-27, status=1, ipAttribution=)]
    2016-10-28 半夏微凉

    学习了,继续关注!

    0

  9. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0f261920920, createdName=上邪zyy, createdTime=Thu Oct 27 20:16:27 CST 2016, time=2016-10-27, status=1, ipAttribution=)]
    2016-10-27 1de8ed50m80(暂无匿称)

    真的吗?保护好我们的牙齿

    0

  10. 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likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Fri Oct 28 06:25:59 CST 2016, time=2016-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=151582, encodeId=35a6151582e4, content=真的吗?保护好我们的牙齿, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87421705485, createdName=1de8ed50m80(暂无匿称), createdTime=Thu Oct 27 20:17:49 CST 2016, time=2016-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=151581, encodeId=71af15158109, content=好好保护牙齿, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0f261920920, createdName=上邪zyy, createdTime=Thu Oct 27 20:16:27 CST 2016, time=2016-10-27, status=1, ipAttribution=)]
    2016-10-27 上邪zyy

    好好保护牙齿

    0

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