Hypertension:出生体重对左室质量有长期影响

2012-10-03 张一宸译 医学论坛网

  出生时体重和儿童早期生长是否与青春期左室质量(LVM)相关以往尚无定论。据猜测左心室生长和结构重建可能对人体一生的心血管健康存在长期作用。9月17日,《高血压》杂志在线发表一项研究,表明出生体重对左室质量(LVM)存在长期影响,出生体重正常对青春期心脏结构有益。   研究分析了决定青春期LVM和结构重建的因素,尤其关注了出生体重和儿童早期生长两个因素的作用。研究数据是418位年龄15岁青少年

  出生时体重和儿童早期生长是否与青春期左室质量(LVM)相关以往尚无定论。据猜测左心室生长和结构重建可能对人体一生的心血管健康存在长期作用。9月17日,《高血压》杂志在线发表一项研究,表明出生体重对左室质量(LVM)存在长期影响,出生体重正常对青春期心脏结构有益。

  研究分析了决定青春期LVM和结构重建的因素,尤其关注了出生体重和儿童早期生长两个因素的作用。研究数据是418位年龄15岁青少年的超声心动图资料,来源于芬兰土尔库冠心病特殊危险因素干预项目(STRIP)。

  分析结果表明,出生体重(P=0.0004)、脉压(P=0.013)、体育锻炼水平(P=0.0024)、当前体重(P<0.0001)以及性别(P<0.001)与青春期LVM独立相关。儿童早期生长与青春期LVM无关。出生体重(P=0.0066)、当前体重(P<0.0001)和体育锻炼水平(P=0.0017)与左心室后壁厚度直接相关。当前体重还与左心室室间隔厚度相关(P<0.0001)。相关室壁厚度正常和左室质量指数(偏心性重建)(P<0.0001)、两个变量同时增加(向心性,LVM增加)(P=0.0003)均与高体质指数相关。

  链接:

 Hietalampi H, Pahkala K, Jokinen E, Rönnemaa T, Viikari JS, Niinikoski H, Heinonen OJ, Salo P, Simell O, Raitakari OT. Left Ventricular Mass and Geometry in Adolescence: Early Childhood Determinants.Hypertension. 2012 Sep 17.

 


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