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Nat Commun：新研究揭示lncRNA FILNC1在癌症代谢中的作用机制

2017-10-11 MedSci MedSci原创

lncRNAFILNC1肾癌
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目前关于长期非编码RNA在癌症代谢中的作用仍知之甚少。本研究中，研究人员通过FoxO转录因子鉴定FILNC1（FoxO诱导的长非编码RNA 1）作为能量应激诱导的长非编码RNA。肾癌细胞FILNC1缺乏可减轻能量应激诱导的细胞凋亡，并可明显促进肾肿瘤的发生。本研究结果显示，FILNC1缺乏可通过上调c-Myc增加葡萄糖的摄取和乳酸的产生。在能量应激下，FILNC1与AUF1（一种c-Myc mRN

目前关于长期非编码RNA在癌症代谢中的作用仍知之甚少。本研究中，研究人员通过FoxO转录因子鉴定FILNC1（FoxO诱导的长非编码RNA 1）作为能量应激诱导的长非编码RNA。肾癌细胞FILNC1缺乏可减轻能量应激诱导的细胞凋亡，并可明显促进肾肿瘤的发生。

本研究结果显示，FILNC1缺乏可通过上调c-Myc增加葡萄糖的摄取和乳酸的产生。在能量应激下，FILNC1与AUF1（一种c-Myc mRNA结合蛋白）相互作用，并可阻断AUF1与c-Myc mRNA的结合，导致c-Myc蛋白的表达下调。FILNC1在肾脏中特异性表达，在肾细胞癌中下调；此外，其低表达与肾细胞癌的临床结局较差相关。

总之，该研究结果不仅鉴定了FILNC1是具有潜在临床价值的肾癌阴性调节因子，还揭示了长非编码RNA在控制能量代谢和肿瘤发展中的调节机制。

原始出处：

Zhen-Dong Xiao, Leng Han, et al., Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development. Nat Commun. 2017; 8: 783. Published online 2017 Oct 4. doi: 10.1038/s41467-017-00902-z

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    2018-06-30 liuli5079

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    2018-04-15 liye789132251

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    2018-02-08 yanjie6253_56072842

    #CRN#

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    2017-10-13 xzw113

    #lncRNA#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2087147, encodeId=2488208e14705, content=<a href='/topic/show?id=490750196b' target=_blank style='color:#2F92EE;'>#COMMUN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Sat Jun 30 00:29:00 CST 2018, time=2018-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1882509, encodeId=cad7188250926, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Sun Apr 15 23:29:00 CST 2018, time=2018-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2005657, encodeId=e8ec200565e53, content=<a href='/topic/show?id=6ff1525e13' target=_blank style='color:#2F92EE;'>#CRN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5257, encryptionId=6ff1525e13, topicName=CRN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=35fc2500023, createdName=yanjie6253_56072842, createdTime=Thu Feb 08 09:29:00 CST 2018, time=2018-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1301876, encodeId=967013018e6f2, content=<a href='/topic/show?id=b469109e41d' target=_blank style='color:#2F92EE;'>#lncRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10974, encryptionId=b469109e41d, topicName=lncRNA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2317301, createdName=xzw113, createdTime=Fri Oct 13 03:29:00 CST 2017, time=2017-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=252027, encodeId=051f25202ed2, content=内容丰富.值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Wed Oct 11 20:10:37 CST 2017, time=2017-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=251984, encodeId=1c0725198474, content=目前关于长期非编码RNA在癌症代谢中的作用仍知之甚少., beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Wed Oct 11 16:45:48 CST 2017, time=2017-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=251931, encodeId=11c425193141, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=7dcf1938111, createdName=1e0e5a1fm42(暂无匿称), createdTime=Wed Oct 11 13:21:52 CST 2017, time=2017-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=251921, encodeId=87722519216f, content=谢谢分享. , beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Wed Oct 11 12:50:36 CST 2017, time=2017-10-11, status=1, ipAttribution=)]
    2017-10-11 虈亣靌

    内容丰富.值得学习

    0

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    2017-10-11 有备才能无患

    目前关于长期非编码RNA在癌症代谢中的作用仍知之甚少.

    0

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    2017-10-11 1e0e5a1fm42(暂无匿称)

    henhao

    0

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    2017-10-11 doctorJiangchao

    谢谢分享.

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