Ann Intern Med:HIV感染者的预期寿命可与正常未感染者接近

2016-11-16 xing.T MedSci原创

世界上许多地方的HIV感染者仍然不能获得最新的疗法所带来的好处。解决这些医疗护理的障碍是很重要,“因为这份以及其他类似的报告证明了其好处,我们可以期待在及时诊断、综合解决方案和新疗法方面的聚焦。”

只要有最佳的护理,感染HIV的个体其寿命可以接近未感染病毒的正常人,一个新的分析报告的作者说道。
 
“对于许多能够获得护理的HIV感染者,影响寿命和健康生活的主要障碍是生活方式因素,而与HIV病毒感染不直接相关。”Nicolai Lohse博士和Niels Obel博士,在11月15日发表于Annals of Internal Medicine杂志上的信函中写道。
 
这个结论来自于2007年作者对一项分析进行的更新,这项更新中揭示了25岁以下的年轻人感染了HIV病毒但不伴有丙型肝炎病毒(HCV)感染时,他们的中位生存年龄为63.9岁。虽然这些数据是“令人备受鼓舞的”,但是从一般人群中抽取的年龄和性别相匹配的样本,其中的研究对象预期寿命仍要短12.2年。
 
该项新分析的作者,均来自丹麦哥本哈根大学,估计了中位生存期在5个阶段过程中的变化,该5个阶段为:1995年–1996年,1997年–1999年,2000年–2004年,2005年–2009年和2010年–2015年。这项研究纳入了丹麦所有的HIV感染者,但不包括9.7%同时感染了HCV的患者。每个病人都从一般人群中匹配了五个年龄和性别相似的对照者。
 
在这项分析中包括了5701名HIV感染者和28,505名对照者,研究人员对HIV感染者共进行60,270人次每年的观察,对照组进行了365,713人次每年的观察。“这项研究包含77%的男性,参与者在进入研究之时的平均年龄为37.1岁(四分位间距为30.5–45.5岁),”作者写道。
 
在1995年-1996期间,25岁的HIV感染者估计的中位死亡年龄为34.5岁(95%可信区间为32.3-35.9岁)。在1997年-1999年期间,估计的中位死亡年龄上升到了52.2岁(95%可信区间为49-57.5岁);在2000年-2004年期间,估计的中位死亡年龄上升到62.8岁(95%可信区间为60.4-64.9岁);在2005年-2009年期间,估计的中位死亡年龄上升到66.8年(95%可信区间为65.7-68.5岁);在2010年-2015年期间,估计的中位死亡年龄上升到73.9年(95%可信区间为72.2-76.7岁)。作者将这些估计值与一般人群中的平均预期寿命80岁(95%可信区间为79.4-80.8岁)进行了比较。
 
作者总结认为,世界上许多地方的HIV感染者仍然不能获得最新的疗法所带来的好处。解决这些医疗护理的障碍是很重要,“因为这份以及其他类似的报告证明了其好处,我们可以期待在及时诊断、综合解决方案和新疗法方面的聚焦。”
 
原始出处:
 
1.Nicolai Lohse , et al. Update of Survival for Persons With HIV Infection in Denmark. Ann Intern Med. 2016;165:749-750
 
2.Norra MacReady. Life Expectancy With HIV Nears That of Uninfected Peers. Medscape Medical News. November 14, 2016

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    2016-11-22 1deb0fb2m59(暂无匿称)

    生命在于质量

    0

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    2016-11-17 studylzc

    期待进展。

    0

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