European Respiratory Journal:阻塞性睡眠呼吸暂停可加速衰老,持续气道正压通气治疗后可部分逆转

2022-03-19 网络 网络

OSA会加速衰老过程,经有效治疗后,OSA患者生物年龄增长是部分可逆的

阻塞性睡眠呼吸暂停(OSA)导致氧化应激和全身炎症途径的激活和增殖,本质上模仿加速的生物衰老(衰老)。阻塞性睡眠呼吸暂停影响广泛,是最普遍的睡眠障碍之一。阻塞性睡眠呼吸暂停与高血压、心脏病发作、中风、糖尿病和许多慢性病高风险相关。

近日,密苏里大学医学院Rene Cortese等在Eur Respir J杂志发表题为" Epigenetic age acceleration in obstructive sleep apnea is reversible with adherent treatment "的研究文章,该研究发现阻塞性睡眠呼吸暂停会加速衰老过程,适当的治疗可以减缓或可能逆转这一趋势

该研究分析了16名被诊断OSA的成年非吸烟者,并纳入8名无症状对照受试者,评估了OSA在一年内对表观遗传年龄加速的影响。通过验血记录表观遗传年龄。OSA组接受持续气道正压通气(CPAP)治疗一年后再次接受检测。

研究发现,阻塞性睡眠呼吸暂停引起的睡眠中断和睡眠期间氧气水平比对照组低,并促进了更快的生物年龄加速。CPAP治疗后,OSA患者表观遗传年龄减速,对照组的年龄增长趋势没有改变。

OSA患者组和对照组生物年龄评估

总之,该研究发现OSA会加速衰老过程,经有效治疗后,OSA患者生物年龄增长是部分可逆的。Rene Cortese等认为成功减缓年龄加速的关键是坚持每晚至少使用4小时CPAP治疗。

原文出处

Cortese R, Sanz-Rubio D, Kheirandish-Gozal L, Marin JM, Gozal D. Epigenetic age acceleration in obstructive sleep apnea is reversible with adherent treatment [published online ahead of print, 2022 Jan 27]. Eur Respir J. 2022;2103042. doi:10.1183/13993003.03042-2021

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    2022-04-15 tomyang96
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    2023-01-08 feather89
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    2022-03-19 清漩

    #学习#学习

    0

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