Aliment Pharmacol Ther:治疗酒精依赖 药物“打败”社会心理干预?

2017-05-11 石岩 环球医学

2017年4月,发表在《Aliment Pharmacol Ther》的一项由英国科学家发表的综述,考察了药物治疗酒精依赖的原因、现状和优势。

2017年4月,发表在《Aliment Pharmacol Ther》的一项由英国科学家发表的综述,考察了药物治疗酒精依赖的原因、现状和优势。

背景:酒精依赖进展与显着的发病率和死亡率相关。对于大多数受影响的人,最合适的目标是依据饮酒行为戒除酒精。社会心理干预是主要的治疗方式,但辅助药物治疗也是有效且推荐的方式。

目标:为酒精依赖管理提供一个基于目前和潜在的药物治疗选择的更新分析。此外,探索治疗结局预测因素,包括依从性和药物遗传学,以及当前治疗障碍,包括医生不愿意开具药物处方。

方法:按广泛的、不限制语言和数据,电子和手动检索文献来选取综述的相关论文。

结果:阿坎酸和纳曲酮有基于全部有效性、安全性和成本效果的大量证据,而与戒酒硫使用相关的风险众所周知,对适当患者的选取和监督可最小化。阿坎酸能安全地用于肝病患者,以及那些共患心理健康问题和同时发生药物相关问题的患者。正在研究一些其他药物对此指征的可能使用,包括:巴氯芬、托吡酯和美他多辛。

结论:酒精依赖的药物治疗已经显示了中度有效性和极少的安全性问题,但是实质上未被充分利用。为了实现此病患者的最佳管理,必须协同努力以消除治疗阻碍。

原始出处:

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    2017-11-23 jj000001
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    2018-01-10 yb6560
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time=2017-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197036, encodeId=ba4a19e036f6, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Fri May 12 10:21:47 CST 2017, time=2017-05-12, status=1, ipAttribution=)]
    2017-05-17 jacob9231

    学习了,谢谢分享

    0

  7. 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href='/topic/show?id=5e1f954e563' target=_blank style='color:#2F92EE;'>#酒精依赖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95475, encryptionId=5e1f954e563, topicName=酒精依赖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f5c116191457, createdName=xue8607, createdTime=Sat May 13 13:13:00 CST 2017, time=2017-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1616688, encodeId=01d5161668820, content=<a href='/topic/show?id=e660e3936c0' target=_blank style='color:#2F92EE;'>#社会#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73936, encryptionId=e660e3936c0, topicName=社会)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6de19781024, createdName=ms705947299214030, createdTime=Sat May 13 13:13:00 CST 2017, time=2017-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197036, encodeId=ba4a19e036f6, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Fri May 12 10:21:47 CST 2017, time=2017-05-12, status=1, ipAttribution=)]
    2017-05-13 天涯183

    非常好的文章,学习了,很受益

    0

  8. 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time=2017-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197036, encodeId=ba4a19e036f6, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Fri May 12 10:21:47 CST 2017, time=2017-05-12, status=1, ipAttribution=)]
  9. 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  10. 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time=2017-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197036, encodeId=ba4a19e036f6, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Fri May 12 10:21:47 CST 2017, time=2017-05-12, status=1, ipAttribution=)]
    2017-05-12 明月清辉

    谢谢分享,学习了

    0

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许多研究报道了生活方式因素对睾丸功能、精子参数和垂体-性腺轴的负面影响,但是,由于对普通群体的研究很少,结论很难定下。最近,研究人员尝试去阐释突然的生活方式改变对年轻男性生殖功能早的和晚的短期影响。研究人员将参加葡萄牙学术活动的36名健康男性学生作为研究对象,并在三个时间点让他们提供了精液样本和答复的调查问卷。在学术活动期间,酒精和烟草的消费分别增加了8倍和2倍,并导致了精液质量的有害影响。在活动

气候还能影响酒精性肝硬化?

荷兰阿姆斯特丹2017年国际肝脏大会今天发布的新数据表明,世界上较冷和缺少阳光的地区,酒精性肝硬化发生率较高,酒精性肝硬化是由过度饮酒导致的肝脏不可逆转的瘢痕形成引起的疾病。一个来自190多个国家的国际科学家分析数据发现,每升高一摄氏度的温度与肝硬化的酒精归因分数(AAF *)下降0.3%有关。重度酒精摄入导致温暖的感觉,而较少的阳光接触与抑郁症有关,

JAAD:喝酒可能导致女性酒渣鼻!

随着周末的临近,我们许多人都期待着能和朋友们喝上一两杯。然而,一项最新研究表明,关注皮肤健康的女性朋友可能要避开白葡萄酒和白酒了。

Prostate Cancer P D:总量和酒精饮料摄入与侵入性前列腺癌风险

酒精饮料中的乙醇是知名的致癌物质,但是它与侵入性前列腺癌(APC)的关系却并不知晓。近期的一些研究指出,APC患病率的一定程度增加与大量酒精摄入有关系,但是对酒精饮料的类型仍旧不清楚。最近,研究人员利用案例-对照设计和自我陈述调查就APC与酒精摄入频率和量的关系进行了研究,酒精摄入超过两年的优先考虑,并且APC包括高级和晚期两种阶段。更多的是,研究人员描述了酒精饮料啤酒、红酒、白酒和烈酒与APC的

严家新答网友:70%酒精灭活狂犬病毒无效?

答网友:70%酒精灭活狂犬病毒无效?是挑战常识,还是对实验数据的误解和误传? 近来,有多位网友在我的博客和微信公众号中提出疑问:70%酒精灭活狂犬病毒是否无效? 例如,网名为 kjz35 的网友 2017-3-16在我的科学网博客中留言: 严老师,孟胜利博士的一篇博文中说 70%的酒精对灭活狂犬病毒无效,记得您说过酒精是可以立即灭活狂犬病毒的,