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Hypertension：Akap1，线粒体A型激酶锚定蛋白，可调控血管功能和内皮细胞的特性。

2018-01-18 MedSci MedSci原创

Akap1A型激酶锚定蛋白线粒体自噬血管内皮
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现已确定经典Notch信号在胚胎造血干细胞产生和胸腺T细胞发育过程中发挥重要作用，但其在成人骨髓（BM）造血中的作用尚不清楚。线粒体A型激酶锚定蛋白，mitoAKAPs，由Akap1基因编码，调节多个细胞过程，维持线粒体稳态和细胞活力。尽管线粒体改变与内膜功能障碍相关，但目前，mitoAKAPs在血管内皮的作用尚不清楚。研究人员通过分析Akap1敲除小鼠（Akap1-/-）及其同窝的野生（wt）对

现已确定经典Notch信号在胚胎造血干细胞产生和胸腺T细胞发育过程中发挥重要作用，但其在成人骨髓（BM）造血中的作用尚不清楚。线粒体A型激酶锚定蛋白，mitoAKAPs，由Akap1基因编码，调节多个细胞过程，维持线粒体稳态和细胞活力。尽管线粒体改变与内膜功能障碍相关，但目前，mitoAKAPs在血管内皮的作用尚不清楚。

研究人员通过分析Akap1敲除小鼠（Akap1-/-）及其同窝的野生（wt）对照小鼠的缺血后新生血管、血管功能和动脉血压，来探索mitoAKAPs在血管内皮的作用。同时原代培养Akap1-/-和wt小鼠的动脉血管内皮细胞（ECs），探索在不同实验条件下ECs的迁移、增殖、存活和毛细血管样网形成。与wt小鼠相比，Akap1-/-小鼠股动脉结扎后，表现为血流受损、功能恢复，骨骼肌血管密度降低，Akt磷酸化。而在Akap1-/- ECs中，低氧诱导的线粒体自噬、线粒体功能障碍、活性氧类产物和凋亡明显增强。此外，Akap1-/- ECs的毛细血管样网络形成、迁移、增殖和AKT磷酸化也相应的降低。Akap1-/- ECs的反应改变在Akap-/-小鼠中得到验证，Akap-/-小鼠表现为选择性降低乙酰胆碱诱导的肠系膜动脉舒张和动脉血压稍升高。最后，过表达持续活跃的Akt突变可修复Akap1-/-状态下的血管反应性和ECs的功能。

本研究结果证明在体内外，mitoAKAPs在调控ECs的多种功能上都发挥重要作用，提示线粒体依赖性的ECs调节或许可作为一种新的治疗方式，用于治疗内皮功能障碍的心血管疾病。

原始出处：

Gabriele Giacomo Schiattarella，et al.Akap1 Regulates Vascular Function and Endothelial Cells Behavior.Hypettension. January 15，2018.https：//doi.org/10.1161/HYPERTENSIONAHA.117.10185

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    2018-09-16 12498ebem19暂无昵称

    #TENS#

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    2018-02-28 ylz8403

    #A型激酶锚定蛋白#

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    2018-10-23 feather89

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    2018-01-20 redcrab

    #激酶#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2038821, encodeId=95b2203882111, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Sun Sep 16 23:31:00 CST 2018, time=2018-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1780268, encodeId=e36a1e8026848, content=<a href='/topic/show?id=bd1d3105ab' target=_blank style='color:#2F92EE;'>#A型激酶锚定蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3105, encryptionId=bd1d3105ab, topicName=A型激酶锚定蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3fce464, createdName=ylz8403, createdTime=Wed Feb 28 04:31:00 CST 2018, time=2018-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1726997, encodeId=33351e2699775, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Tue Oct 23 19:31:00 CST 2018, time=2018-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1496000, encodeId=ccd0149600087, content=<a href='/topic/show?id=9c516685eea' target=_blank style='color:#2F92EE;'>#激酶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66857, encryptionId=9c516685eea, topicName=激酶)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=73449239400, createdName=redcrab, createdTime=Sat Jan 20 12:31:00 CST 2018, time=2018-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501249, encodeId=6e5e1501249d1, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Sat Jan 20 12:31:00 CST 2018, time=2018-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1511984, encodeId=a767151198476, content=<a href='/topic/show?id=da82895e077' target=_blank style='color:#2F92EE;'>#血管功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89570, encryptionId=da82895e077, topicName=血管功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a8810427189, createdName=1249859em41(暂无昵称), createdTime=Sat Jan 20 12:31:00 CST 2018, time=2018-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279834, encodeId=dfab2e98345c, content=内皮细胞仍然是研究的热点, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/12/31/60fc0213ae09a3dbbba19993663ef4db.jpg, createdBy=33c31971480, createdName=1e160a78m83(暂无匿称), createdTime=Thu Jan 18 23:00:22 CST 2018, time=2018-01-18, status=1, ipAttribution=)]
    2018-01-20 jambiya

    #Hypertension#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2038821, encodeId=95b2203882111, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Sun Sep 16 23:31:00 CST 2018, time=2018-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1780268, encodeId=e36a1e8026848, content=<a href='/topic/show?id=bd1d3105ab' target=_blank style='color:#2F92EE;'>#A型激酶锚定蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3105, encryptionId=bd1d3105ab, topicName=A型激酶锚定蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3fce464, createdName=ylz8403, createdTime=Wed Feb 28 04:31:00 CST 2018, time=2018-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1726997, encodeId=33351e2699775, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Tue Oct 23 19:31:00 CST 2018, time=2018-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1496000, encodeId=ccd0149600087, content=<a href='/topic/show?id=9c516685eea' target=_blank style='color:#2F92EE;'>#激酶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66857, encryptionId=9c516685eea, topicName=激酶)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=73449239400, createdName=redcrab, createdTime=Sat Jan 20 12:31:00 CST 2018, time=2018-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501249, encodeId=6e5e1501249d1, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Sat Jan 20 12:31:00 CST 2018, time=2018-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1511984, encodeId=a767151198476, content=<a href='/topic/show?id=da82895e077' target=_blank style='color:#2F92EE;'>#血管功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89570, encryptionId=da82895e077, topicName=血管功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a8810427189, createdName=1249859em41(暂无昵称), createdTime=Sat Jan 20 12:31:00 CST 2018, time=2018-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279834, encodeId=dfab2e98345c, content=内皮细胞仍然是研究的热点, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/12/31/60fc0213ae09a3dbbba19993663ef4db.jpg, createdBy=33c31971480, createdName=1e160a78m83(暂无匿称), createdTime=Thu Jan 18 23:00:22 CST 2018, time=2018-01-18, status=1, ipAttribution=)]
    2018-01-20 1249859em41(暂无昵称)

    #血管功能#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2038821, encodeId=95b2203882111, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Sun Sep 16 23:31:00 CST 2018, time=2018-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1780268, encodeId=e36a1e8026848, content=<a href='/topic/show?id=bd1d3105ab' target=_blank style='color:#2F92EE;'>#A型激酶锚定蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3105, encryptionId=bd1d3105ab, topicName=A型激酶锚定蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3fce464, createdName=ylz8403, createdTime=Wed Feb 28 04:31:00 CST 2018, time=2018-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1726997, encodeId=33351e2699775, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Tue Oct 23 19:31:00 CST 2018, time=2018-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1496000, encodeId=ccd0149600087, content=<a href='/topic/show?id=9c516685eea' target=_blank style='color:#2F92EE;'>#激酶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66857, encryptionId=9c516685eea, topicName=激酶)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=73449239400, createdName=redcrab, createdTime=Sat Jan 20 12:31:00 CST 2018, time=2018-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501249, encodeId=6e5e1501249d1, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Sat Jan 20 12:31:00 CST 2018, time=2018-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1511984, encodeId=a767151198476, content=<a href='/topic/show?id=da82895e077' target=_blank style='color:#2F92EE;'>#血管功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89570, encryptionId=da82895e077, topicName=血管功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a8810427189, createdName=1249859em41(暂无昵称), createdTime=Sat Jan 20 12:31:00 CST 2018, time=2018-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279834, encodeId=dfab2e98345c, content=内皮细胞仍然是研究的热点, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/12/31/60fc0213ae09a3dbbba19993663ef4db.jpg, createdBy=33c31971480, createdName=1e160a78m83(暂无匿称), createdTime=Thu Jan 18 23:00:22 CST 2018, time=2018-01-18, status=1, ipAttribution=)]
    2018-01-18 1e160a78m83(暂无匿称)

    内皮细胞仍然是研究的热点

    0