Int J Antimicrob Ag:多学科抗菌药管理团队做出的非抗生素建议的临床影响

2017-08-21 吴刚 环球医学

2017年8月,发表在《Int J Antimicrob Agents》的一项由新加坡科学家进行的研究,考察了多学科抗菌药管理团队做出的非抗生素建议的临床影响。



2017年8月,发表在《Int J Antimicrob Agents》的一项由新加坡科学家进行的研究,考察了多学科抗菌药管理团队做出的非抗生素建议的临床影响。

介绍:教学医院中,多学科抗菌药管理团队对所有哌拉西林他唑巴坦和碳青霉烯类抗生素住院患者处方进行了一项前瞻性回顾和反馈。此外,团队提供了非抗生素建议(如,额外的调查和感染性疾病审查)。本研究旨在描述这些建议对患者结局的影响。

方法:2012年1月~2014年8月,哌拉西林他唑巴坦和碳青霉烯类抗生素治疗并且接受了至少一个非抗生素建议的患者纳入到本研究中。研究者比较了主治医师给出的非抗生素建议的接受和拒绝情况。首要结局为30天死亡率。

结果:为166例患者做出了非抗生素建议。接受建议和拒绝建议的患者间,基线特征无差异。接受至少1个非抗生素建议的患者的30天死亡率显着性低(18.0% vs 34.5%;P=0.02)。多变量分析显示,Charlson合并症评分(比值比OR,1.20;95% CI,1.03~1.42;P=0.03)、APACHE II评分(1.10;1.01~1.19;P<0.01)、肝胆感染源(10.19;1.44~72.13;P=0.02)、接受至少一个非抗生素建议(0.39;0.17~0.88;P=0.02)与30天死亡率独立相关。

结论:哌拉西林他唑巴坦和碳青霉烯类抗生素的前瞻性回顾和反馈期间,非抗生素建议的接受与30天死亡率的降低相关。

原始出处

Ng TM, Phang VY, Young B, et al. Clinical impact of non-antibiotic recommendations by a multi-disciplinary antimicrobial stewardship team. Int J Antimicrob Agents. 2017 Aug;50(2):166-170. doi: 10.1016/j.ijantimicag.2017.01.046. Epub 2017 Jun 15.

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    2018-04-07 xjy02
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    2017-08-23 lietome24

    感谢小编为我们准备了如此丰盛的精神大餐.同时也向作者致谢!认真学习了.点赞!

    0

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    2017-08-23 lhlxtx
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    2017-08-23 yfjms

    学习了

    0

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