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Blood：20号染色体缺失是乳房植入物相关间变性大细胞淋巴瘤的特征！

2021-01-05 Nebula MedSci原创

BIA-ALCL乳房植入物相关间变性大细胞淋巴瘤20号染色体缺失
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乳房植入相关间变性大细胞淋巴瘤(BIA-ALCL)是一种非常罕见的由单一环境刺激引起的T细胞淋巴瘤

乳房植入相关间变性大细胞淋巴瘤(BIA-ALCL)是一种非常罕见的由单一环境刺激引起的T细胞淋巴瘤，但其发生率呈上升趋势。

在本研究中，Tjitske等对一个相对较大的BIA-ALCL队列(n=29)进行了综合性遗传分析，明确了其中一个子集(n=7)的全基因组染色体拷贝数变异(CNA)和突变图谱。为了进行比较，研究人员还获得了间变性淋巴瘤激酶(ALK)阴性（-）结节性间变性大细胞淋巴瘤(ALCL；n=24)的CNA。

29例BIA-ALCL和ALK-nALCL的CNA

经分析发现，在94%的BIA-ALCL中检测到了CNA，其中66%的样本的拷贝数缺失位于染色体20q13.13区域。20q13.13缺失是BIA-ALCL不同于其他类型ALCL的特征，如原发性皮肤型ALCL、全身型ALK+和ALK-ALCL。

血清BIA-ALCL和肿瘤BIA-ALCL的CNA对比

突变模式证实，白细胞介素-6-JAK1-STAT3通路失调。虽然这在不同类型的T细胞淋巴瘤中都很常见，但该通路在BIA-ALCL中失调的程度明显更高。

总之，BIA-ALCL中20号染色体的特征性丢失进一步证明了BIA-ALCL是一个独立的疾病实体。此外，CNA分析可以作为未来有乳房植入物的女性的诊断试验的参数，以区分是由BIA-ALCL引起的血清肿还是其他原因，如感染或创伤，引起的血清肿。

原始出处：

Los-de Vries G Tjitske,de Boer Mintsje,van Dijk Erik et al. Chromosome 20 loss is characteristic of breast implant-associated anaplastic large cell lymphoma.[J] .Blood, 2020, 136: 2927-2932.

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    2021-03-11 fzwish20000

    #乳房植入#

    0

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    2021-09-12 marlenexl

    #细胞淋巴瘤#

    0

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    2021-01-07 新生儿张玉军

    #染色体#

    0

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    2021-01-07 huangdf

    #变性#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1797708, encodeId=46dc1e9770832, content=<a href='/topic/show?id=8d1423633a6' target=_blank style='color:#2F92EE;'>#乳房植入#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23633, encryptionId=8d1423633a6, topicName=乳房植入)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bcaa382, createdName=fzwish20000, createdTime=Thu Mar 11 01:04:30 CST 2021, time=2021-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1702660, encodeId=b0631e026600c, content=<a href='/topic/show?id=ddc9e795159' target=_blank style='color:#2F92EE;'>#细胞淋巴瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77951, encryptionId=ddc9e795159, topicName=细胞淋巴瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=201630414353, createdName=marlenexl, createdTime=Sun Sep 12 14:04:30 CST 2021, time=2021-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1331747, encodeId=39541331e4714, content=<a href='/topic/show?id=d85a6181e4d' target=_blank style='color:#2F92EE;'>#染色体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61817, encryptionId=d85a6181e4d, topicName=染色体)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKnILSXam1GxPwj04ylEzibYLFA2eGl5Ev02klt80JA0xejMPqrn0mYHNNnLEgyqYTPbicXpY3tn6SA/132, createdBy=38fd2500059, createdName=新生儿张玉军, createdTime=Thu Jan 07 12:04:30 CST 2021, time=2021-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1463743, encodeId=1c581463e4333, content=<a href='/topic/show?id=7d27381288e' target=_blank style='color:#2F92EE;'>#变性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38128, encryptionId=7d27381288e, topicName=变性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f69f6545041, createdName=huangdf, createdTime=Thu Jan 07 12:04:30 CST 2021, time=2021-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1490940, encodeId=5827149094014, content=<a href='/topic/show?id=fb916268636' target=_blank style='color:#2F92EE;'>#植入物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62686, encryptionId=fb916268636, topicName=植入物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=38628846382, createdName=linagood, createdTime=Thu Jan 07 12:04:30 CST 2021, time=2021-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1520721, encodeId=f94b1520e2138, content=<a href='/topic/show?id=7a736264553' target=_blank style='color:#2F92EE;'>#植入#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62645, encryptionId=7a736264553, topicName=植入)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=832411313664, createdName=jiyangfei, createdTime=Thu Jan 07 12:04:30 CST 2021, time=2021-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=913972, encodeId=3f929139e270, content=学习了，受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=714a5450378, createdName=ms5000000584818392, createdTime=Tue Jan 05 21:40:34 CST 2021, time=2021-01-05, status=1, ipAttribution=)]
    2021-01-07 linagood

    #植入物#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1797708, encodeId=46dc1e9770832, content=<a href='/topic/show?id=8d1423633a6' target=_blank style='color:#2F92EE;'>#乳房植入#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23633, encryptionId=8d1423633a6, topicName=乳房植入)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bcaa382, createdName=fzwish20000, createdTime=Thu Mar 11 01:04:30 CST 2021, time=2021-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1702660, encodeId=b0631e026600c, content=<a href='/topic/show?id=ddc9e795159' target=_blank style='color:#2F92EE;'>#细胞淋巴瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77951, encryptionId=ddc9e795159, topicName=细胞淋巴瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=201630414353, createdName=marlenexl, createdTime=Sun Sep 12 14:04:30 CST 2021, time=2021-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1331747, encodeId=39541331e4714, content=<a href='/topic/show?id=d85a6181e4d' target=_blank style='color:#2F92EE;'>#染色体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61817, encryptionId=d85a6181e4d, topicName=染色体)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKnILSXam1GxPwj04ylEzibYLFA2eGl5Ev02klt80JA0xejMPqrn0mYHNNnLEgyqYTPbicXpY3tn6SA/132, createdBy=38fd2500059, createdName=新生儿张玉军, createdTime=Thu Jan 07 12:04:30 CST 2021, time=2021-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1463743, encodeId=1c581463e4333, content=<a href='/topic/show?id=7d27381288e' target=_blank style='color:#2F92EE;'>#变性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38128, encryptionId=7d27381288e, topicName=变性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f69f6545041, createdName=huangdf, createdTime=Thu Jan 07 12:04:30 CST 2021, time=2021-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1490940, encodeId=5827149094014, content=<a href='/topic/show?id=fb916268636' target=_blank style='color:#2F92EE;'>#植入物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62686, encryptionId=fb916268636, topicName=植入物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=38628846382, createdName=linagood, createdTime=Thu Jan 07 12:04:30 CST 2021, time=2021-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1520721, encodeId=f94b1520e2138, content=<a href='/topic/show?id=7a736264553' target=_blank style='color:#2F92EE;'>#植入#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62645, encryptionId=7a736264553, topicName=植入)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=832411313664, createdName=jiyangfei, createdTime=Thu Jan 07 12:04:30 CST 2021, time=2021-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=913972, encodeId=3f929139e270, content=学习了，受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=714a5450378, createdName=ms5000000584818392, createdTime=Tue Jan 05 21:40:34 CST 2021, time=2021-01-05, status=1, ipAttribution=)]
    2021-01-07 jiyangfei

    #植入#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1797708, encodeId=46dc1e9770832, content=<a href='/topic/show?id=8d1423633a6' target=_blank style='color:#2F92EE;'>#乳房植入#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23633, encryptionId=8d1423633a6, topicName=乳房植入)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bcaa382, createdName=fzwish20000, createdTime=Thu Mar 11 01:04:30 CST 2021, time=2021-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1702660, encodeId=b0631e026600c, content=<a href='/topic/show?id=ddc9e795159' target=_blank style='color:#2F92EE;'>#细胞淋巴瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77951, encryptionId=ddc9e795159, topicName=细胞淋巴瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=201630414353, createdName=marlenexl, createdTime=Sun Sep 12 14:04:30 CST 2021, time=2021-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1331747, encodeId=39541331e4714, content=<a href='/topic/show?id=d85a6181e4d' target=_blank style='color:#2F92EE;'>#染色体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61817, encryptionId=d85a6181e4d, topicName=染色体)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKnILSXam1GxPwj04ylEzibYLFA2eGl5Ev02klt80JA0xejMPqrn0mYHNNnLEgyqYTPbicXpY3tn6SA/132, createdBy=38fd2500059, createdName=新生儿张玉军, createdTime=Thu Jan 07 12:04:30 CST 2021, time=2021-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1463743, encodeId=1c581463e4333, content=<a href='/topic/show?id=7d27381288e' target=_blank style='color:#2F92EE;'>#变性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38128, encryptionId=7d27381288e, topicName=变性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f69f6545041, createdName=huangdf, createdTime=Thu Jan 07 12:04:30 CST 2021, time=2021-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1490940, encodeId=5827149094014, content=<a href='/topic/show?id=fb916268636' target=_blank style='color:#2F92EE;'>#植入物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62686, encryptionId=fb916268636, topicName=植入物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=38628846382, createdName=linagood, createdTime=Thu Jan 07 12:04:30 CST 2021, time=2021-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1520721, encodeId=f94b1520e2138, content=<a href='/topic/show?id=7a736264553' target=_blank style='color:#2F92EE;'>#植入#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62645, encryptionId=7a736264553, topicName=植入)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=832411313664, createdName=jiyangfei, createdTime=Thu Jan 07 12:04:30 CST 2021, time=2021-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=913972, encodeId=3f929139e270, content=学习了，受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=714a5450378, createdName=ms5000000584818392, createdTime=Tue Jan 05 21:40:34 CST 2021, time=2021-01-05, status=1, ipAttribution=)]
    2021-01-05 ms5000000584818392

    学习了，受益匪浅

    0

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