Hypertension:糖尿病患者应用β受体阻滞剂增加心血管风险

2017-06-20 许菁 中国循环杂志

Hypertention发表ACCORD研究最新分析数据显示,不管有无基础心血管疾病,糖尿病患者应用β受体阻滞剂均增加不良心血管事件风险,而且应用β受体阻滞剂的患者的严重低血糖发生率明显高于未应用β受体阻滞剂的患者。

Hypertention发表ACCORD研究最新分析数据显示,不管有无基础心血管疾病,糖尿病患者应用β受体阻滞剂均增加不良心血管事件风险,而且应用β受体阻滞剂的患者的严重低血糖发生率明显高于未应用β受体阻滞剂的患者。

本研究中,应用β受体阻滞剂的2型糖尿病患者的心血管事件发生风险增加46%。合并冠心病或心衰的2型糖尿病患者,不良心血管事件发生风险增加27%。

应用β受体阻滞剂的患者的严重低血糖发生风险增加30%。研究认为,严重低血糖的发生是应用β受体阻滞剂导致不良心血管事件的发生的原因之一。

研究数据显示,在标准治疗组中,应用β受体阻滞剂和未应用者的严重低血糖的发生率并无明显差异,而应用β受体阻滞剂患者的心血管事件发生率仍显着高于未应用者。因此研究者认为,β受体阻滞剂的使用与增加心血管事件的风险之间的关联,可能不能仅仅通过严重的低血糖来解释。

原始出处:
Tsujimoto T, Sugiyama T, Shapiro M. Risk of Cardiovascular Events in Patients With Diabetes Mellitus on β-Blockers Novelty and Significance. Hypertension. 2017 Jul;70(1):103-110. doi: 10.1161/HYPERTENSIONAHA.117.09259. Epub 2017 May 30.

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    2017-10-31 feather89
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    2017-08-11 zhyy88
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