J Hypertens:降压同时添加叶酸降低肾病相关死亡风险

2017-05-11 许菁 中国循环杂志

日发布的CSPPT亚组研究数据显示,大量蛋白尿以及肾小球滤过率降低显着增加高血压患者的死亡风险。


日发布的CSPPT亚组研究数据显示,大量蛋白尿以及肾小球滤过率降低显着增加高血压患者的死亡风险。

该研究还首次证实,对于高血压患者,补充叶酸可以降低大量蛋白尿导致的死亡风险。

研究数据显示,单纯应用依那普利的患者中,出现大量蛋白尿患者的死亡率显着高于无蛋白尿患者(10.8% vs 2.7%),而且肾小球滤过率<60ml/min·1.73m2的患者的死亡率显着高于>90 ml/min·1.73m2的患者(13.0% vs 2.2%)。

大量蛋白尿和肾小球滤过率降低分别使高血压患者的死亡风险增加2.3倍和93%。

而在依那普利+叶酸组患者中,出现大量蛋白尿患者的死亡率为6.4%,显着低于单纯依那普利组患者。

补充叶酸使死于大量蛋白尿的风险降低51%,而对于肾小球滤过率降低导致的死亡风险无影响。

研究纳入20702例有心血管病史的高血压患者,其中10348例患者服用依那普利(10mg)+叶酸(0.8mg),10354例患者单纯应用依那普利(10mg),随访4.5年。

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    2018-01-28 feather89
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    2017-05-14 皇家骑士团团尾

    这个有利于药物的选择!

    0

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    2017-05-12 cuiyejia

    学习了,谢谢

    0

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    2017-05-12 flysky120

    学习一下知识了,谢谢

    0

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    2017-05-12 1ddf0692m34(暂无匿称)

    涨知识,值得分享

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    2017-05-11 I come

    长见识了,谢谢分享

    0

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