JACC:血管舒张功能障碍在心绞痛患者中存在性别差异

2017-11-02 MedSci MedSci原创

在冠脉通畅的患者中,冠脉舒张障碍是其心绞痛的重要原因之一。本研究的目的旨在评估欧洲人群中冠脉舒张功能障碍流行病学和临床表现的性别差异。本研究纳入了2007年至2014年1379名伴有稳定心绞痛的冠脉通畅患者,并对部分因毛细血管痉挛而冠状动脉微血管功能障碍(CMD)或心外膜血管痉挛患者进行乙酰胆碱激发实验(ACH)以评估冠脉舒张功能。患者的平均年龄为62岁,男性占42%,最终共有813名(59%)患

在冠脉通畅的患者中,冠脉舒张障碍是其心绞痛的重要原因之一。本研究的目的旨在评估欧洲人群中冠脉舒张功能障碍流行病学和临床表现的性别差异。本研究纳入了2007年至2014年1379名伴有稳定心绞痛的冠脉通畅患者,并对部分因毛细血管痉挛而冠状动脉微血管功能障碍(CMD)或心外膜血管痉挛患者进行乙酰胆碱激发实验(ACH)以评估冠脉舒张功能。患者的平均年龄为62岁,男性占42%,最终共有813名(59%)患者接受了病理性ACH实验,其中33%患者是由于CMD,26%患者由于心外膜血管痉挛,并且女性中更常见(70% vs. 43%; p < 0.001)。多元回归分析后,女性/男性比例对CMD和心外膜血管痉挛的OR值分别为4.2 (95% Cl: 3.1 - 5.5; p < 0.001) 和 2.3 (95% Cl: 1.7 - 3.1; p < 0.001)。与男性患者相比,女性患者在低剂量ACH时对乙酰胆碱更敏感。研究结果显示,在伴有心绞痛的冠脉通畅患者中,血管舒张功能障碍较常见,并且女性患者的比例更高。原始出处:Ahmed A et al.Sex-Related Diff

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    2018-08-20 hbwxf
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    2018-09-13 yahu
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    2017-11-03 Jackie Li

    学习

    0

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    2017-11-02 天涯183

    非常好的文章.学习了

    0

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    2017-11-02 惠映实验室

    学习了.谢谢

    0

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