JCEM：1型糖尿病患者腰围身高比和严重糖尿病眼病风险之间的关系

2021-09-12 MedSci原创 MedSci原创

WHtR是向心性肥胖的标志，与1型糖尿病患者的SDED相关。

1型糖尿病(T1D)患者肥胖患病率有所增加。然而，身体成分与严重糖尿病眼病(SDED)之间的关系尚未明确。

近日，内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章，该研究旨在探究T1D成人身体成分与SDED之间的关联。

研究人员从芬兰糖尿病肾病研究中的5401名T1D成人中，评估了3468名和437名接受双能X射线吸收测定法进行身体成分分析的患者。复合结局为SDED，定义为增殖性视网膜病变、激光治疗、抗VEGF治疗、糖尿病黄斑病变、玻璃体出血和玻璃体切除术。研究人员采用Logistic回归分析评估了身体成分与SDED之间的关联。多变量Cox回归分析评估了人体测量指标与SDED之间的关联。按白蛋白尿分阶段进行亚组分析。

在14.5(IQR为7.8-17.5)年的中位随访期间，共发生了886起SDED事件。内脏/雄性脂肪比率与SDED(OR为1.40,z=3.13)以及内脏(OR为1.80,z=2.45)和雄性脂肪(OR为1.28,z=2.08)的百分比有关，但与全身脂肪百分比无关。腰围身高比（WHtR）与SDED风险之间的相关性最强(HR=1.28,z=3.73)，其次是腰围(HR为1.01,z=3.03)、体重指数(HR为1.03,z=2.33)和腰围-臀围比（HR为1.15，z=2.22）。正常和微量白蛋白尿患者的结果相似，但在大量白蛋白尿患者中不显著。在正常和微量白蛋白尿阶段，WHtR≥0.5使SDED风险增加28%。

由此可见，WHtR是向心性肥胖的标志，与1型糖尿病患者的SDED相关。

原始出处：

Erika B Parente,.et al.Waist-height ratio and the risk of severe diabetic eye disease in type 1 diabetes: a 15-year cohort study.JCEM.2021.https://doi.org/10.1210/clinem/dgab671

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2022-04-03 achengzhao

#JCE#

29 0
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2021-11-07 millore

#1型糖尿病患者#

25 0
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2022-02-13 仁心济世

#JCEM#

20 0
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2021-09-14 naiwu77

#腰围#

42 0
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2021-09-14 xue8604

#糖尿病患者#

33 0
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2021-09-14 pps20023

#眼病#

27 0
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2021-09-13 陶广华

好

62 0
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2021-09-13 misszhang

谢谢MedSci提供最新的资讯

63 0
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2021-09-13 misszhang

谢谢MedSci提供最新的资讯

57 0

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