CLIN CANCER RES：RNF6与结直肠癌不良预后有关

2018-03-28 MedSci MedSci原创

RNF6在肿瘤发生过程中起到重要作用，但是关于结直肠癌中RNF6拷贝数及表达的报道很少。CLIN CANCER RES近期发表了一篇文章，研究RNF6在结直肠癌发生发展过程中的作用。

RNF6在肿瘤发生过程中起到重要作用，但是关于结直肠癌中RNF6拷贝数及表达的报道很少。CLIN CANCER RES近期发表了一篇文章，研究RNF6在结直肠癌发生发展过程中的作用。

作者通过公共数据库研究了RNF6的拷贝数和表达情况。通过rt-PCR，Western blot和免疫组化染色等验证基因表达情况。在体内和体外实验中研究RNF6对肿瘤生长和转移的影响。利用免疫共沉淀和共聚焦显微镜研究RNF6在调节SHP-1表达中发挥的作用。研究结果发现，结直肠癌中RNF6拷贝数显着扩增，该扩增与RNF6表达水平有关。RNF6扩增和过表达与结直肠癌患者不良预后显着相关。基因富集分析表明RNF6高表达的结直肠癌中增殖和侵袭相关基因增加。在体内和体外实验中下调RNF6表达会损伤结直肠癌细胞增殖和侵袭能力。RNF6可能通过诱导SHP-1泛素化和降解激活JAK/STAT3通路，增加pSTAT3水平。

文章最后认为，结直肠癌中基因扩增促进RNF6过表达。RNF6在结直肠癌进展过程中可能成为重要的生物学标志，RNF6通过促进SHP-1泛素化和降解增加pSTAT3水平。靶向RNF6/SHP/STAT3轴为治疗RNF6扩增肿瘤提供了新的选择。

原始出处：

Qian Liang,Dan Ma,et al.RING-Finger Protein 6 Amplification Activates JAK/STAT3 Pathway by Modifying SHP-1 Ubiquitylation and Associates with Poor Outcome in Colorectal Cancer.CLIN CANCER RES.March 2018 doi:10.1158/1078-0432.CCR-17-2133

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学习学习学习

65 0
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2018-03-31 天地飞扬

了解一下.谢谢分享!

67 0
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2018-03-31 jihuaijun1112

学习学习学习

65 0
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2018-03-30 thinkibmz_44722594

#不良预后#

18 0
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2018-03-30 crystal0564

#结直肠#

19 0
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2018-03-28 1e0f8808m18(暂无匿称)

学习了.谢谢分享.

21 0

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