ADA 2015:GLP-1类药物降低体重的奥秘——影响大脑对食物的反应

2015-06-11 佚名 壹生APP

胃肠激素类药物(Gut hormone),如 GLP-1(胰高血糖素样肽 -1)受体激动剂在临床上被用于糖尿病治疗,同时也具有降低体重的作用。研究人员一直在试图揭示其作用机制。6月9日,第 75 届美国糖尿病学会科学年会(ADA 2015)公布的一项研究结果阐述了GLP-1 受体激动剂可改变大脑对食物的反应,这或许能够降低患者对食物的渴望以及增加进食过程中的满足感。    &n

胃肠激素类药物(Gut hormone),如 GLP-1(胰高血糖素样肽 -1)受体激动剂在临床上被用于糖尿病治疗,同时也具有降低体重的作用。研究人员一直在试图揭示其作用机制。6月9日,第 75 届美国糖尿病学会科学年会(ADA 2015)公布的一项研究结果阐述了GLP-1 受体激动剂可改变大脑对食物的反应,这或许能够降低患者对食物的渴望以及增加进食过程中的满足感。
          


既往有研究结果显示,与身材较瘦人群相比,肥胖人群大脑对食物相关的图片反应更为强烈,并且在进食过程中奖赏反应会下降,这些因素可导致摄入食物过多。荷兰阿姆斯特丹的研究人员验证了这一假说:GLP-1 受体激动剂 exenatide(艾塞那肽)可与 GLP-1 受体结合,发挥与内源性 GLP-1 一致的效应——改变患者大脑对食物摄取的反应及降低食欲,从而使 2 型糖尿病患者体重下降。


        
此外,研究人员对明确 GLP-1 受体激动剂是否可以改变人类对毒品、酒精和尼古丁的依赖感兴趣,因为这可能为药物滥用导致的疾病提供治疗靶点。
        
美国食品和药物管理局(FDA)最近批准了首个被允许用于肥胖治疗的GLP-1 受体激动剂。

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    2015-06-29 owlhealth

    不错不错

    0

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    2015-06-25 huaxipanxing

    看看

    0

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    2015-06-13 般若傻瓜
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    2015-06-13 yhy100201
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    2015-06-13 yibei
  6. [GetPortalCommentsPageByObjectIdResponse(id=29947, encodeId=5e852994e07, content=不错不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3b2c1627329, createdName=owlhealth, createdTime=Mon Jun 29 19:03:00 CST 2015, time=2015-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=29426, encodeId=f6562942676, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=157, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Thu Jun 25 23:50:00 CST 2015, time=2015-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1264548, encodeId=9c991264548e8, content=<a href='/topic/show?id=150f19229c' target=_blank style='color:#2F92EE;'>#ADA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1922, encryptionId=150f19229c, topicName=ADA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ad9f79, createdName=般若傻瓜, createdTime=Sat Jun 13 06:55:00 CST 2015, time=2015-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416671, encodeId=e38014166e1ce, content=<a href='/topic/show?id=27c710101804' target=_blank style='color:#2F92EE;'>#食物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101018, encryptionId=27c710101804, topicName=食物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3a33221853, createdName=yhy100201, createdTime=Sat Jun 13 06:55:00 CST 2015, time=2015-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1422691, encodeId=a838142269165, content=<a href='/topic/show?id=54fa80e701' target=_blank style='color:#2F92EE;'>#GLP-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8077, encryptionId=54fa80e701, topicName=GLP-1)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f8f23732777, createdName=yibei, createdTime=Sat Jun 13 06:55:00 CST 2015, time=2015-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=27312, encodeId=dffd2e312a6, content=哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=41521628038, createdName=da1215225, createdTime=Fri Jun 12 16:38:00 CST 2015, time=2015-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=27229, encodeId=6e022e2297e, content=减肥还是增肥?, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e5c31627260, createdName=Darcy2500, createdTime=Thu Jun 11 23:46:00 CST 2015, time=2015-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=27175, encodeId=65922e17589, content=我也想增肥, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Thu Jun 11 21:09:00 CST 2015, time=2015-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=27176, encodeId=5f542e176b9, content=有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Thu Jun 11 21:09:00 CST 2015, time=2015-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=27035, encodeId=14ae2e03548, content=我想增肥, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=efcb1614039, createdName=qinweihan19, createdTime=Thu Jun 11 17:02:00 CST 2015, time=2015-06-11, status=1, ipAttribution=)]
    2015-06-12 da1215225

    哈哈

    0

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    2015-06-11 Darcy2500

    减肥还是增肥?

    0

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    2015-06-11 18619c0a62m

    我也想增肥

    0

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    2015-06-11 18619c0a62m

    有用

    0

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    2015-06-11 qinweihan19

    我想增肥

    0

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