Intens Care Med:通气的机械功率与重症患者死亡率相关

2018-10-11 xing.T MedSci原创

由此可见,接受有创通气至少48小时的ICU患者呼吸机高MP与较高的院内死亡率和其他一些结局独立相关。

机械功率(MP)是一个可以统一已知的、与呼吸机肺损伤发生相关的变量。近日,危重病医学领域权威杂志Intensive Care Medicine上发表了一篇研究文章,该研究的目的是评估过接受有创通气至少48小时的重症患者MP与死亡率之间的关系。

这项研究是对MIMIC-III和eICU数据库中的数据进行的分析,纳入了接受有创通气至少48小时的重症患者。感兴趣的暴露因素为MP。主要结局是院内死亡率。

研究人员分析了8207名患者的数据。在MIMIC-III数据库中第二个24小时期间患者MP的中位数为21.4(16.2-28.1)J/min,在eICU数据库中为16.0(11.7-22.1)J/min。MP与院内死亡率独立相关[每增加5J/min的比值比(OR)为1.06(95%置信区间(CI)为1.01-1.11);在MIMIC-III中p=0.021,在eICU中为1.10(1.02-1.18);p=0.010]。MP还与ICU死亡率、30天死亡率以及无呼吸机天数、ICU和住院天数有关。即使在低潮气量时,高MP也与院内死亡率 [OR为1.70(1.32-2.18); p<0.001]和其它次要结局相关。最后,MP高于17.0 J/min,患者的死亡风险也会增加。
结论

由此可见,接受有创通气至少48小时的ICU患者呼吸机高MP与较高的院内死亡率和其他一些结局独立相关。

原始出处:

Ary Serpa Neto, et al. Mechanical power of ventilation is associated with mortality in critically ill patients: an analysis of patients in two observational cohorts.Intensive Care Medicine.2018. http://icmjournal.esicm.org/journals/abstract.html?v=0&j=134&i=0&a=5375_10.1007_s00134-018-5375-6&doi=

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    2018-10-11 王秀

    学习了,涨知识了!

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1983601, encodeId=f648198360168, content=<a href='/topic/show?id=628553048e3' target=_blank style='color:#2F92EE;'>#患者死亡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53048, encryptionId=628553048e3, topicName=患者死亡)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sun Nov 25 07:48:00 CST 2018, time=2018-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2038977, encodeId=32dd20389e79b, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Sun Apr 28 12:48:00 CST 2019, time=2019-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1284046, encodeId=972d128404644, content=<a href='/topic/show?id=cdb79594643' target=_blank style='color:#2F92EE;'>#重症患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95946, encryptionId=cdb79594643, topicName=重症患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6c3a189, createdName=longqijun248, createdTime=Sat Oct 13 12:48:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1609178, encodeId=2a8a16091e8b2, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sat Oct 13 12:48:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=348939, encodeId=0fd734893945, content=学习了,涨知识了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Thu Oct 11 22:11:54 CST 2018, time=2018-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=348934, encodeId=638934893468, content=了解一下,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=2, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Thu Oct 11 22:05:34 CST 2018, time=2018-10-11, status=1, ipAttribution=)]
    2018-10-11 天地飞扬

    了解一下,谢谢分享!

    0

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