Lancet glob health:重度贫血可明显增加妊娠期和产褥期孕产妇的死亡率

2018-03-22 MedSci MedSci原创

在中低收入国家,贫血将近影响一半的妊娠女性,但该疾病的负担以及与妊娠死亡率的尚无可靠的定量化数据。Jahnavi Daru等人利用WHO多国家对孕产妇和新生儿健康的调查数据对重度贫血和孕产妇死亡之间的关系进行评估。研究人员利用多层次和倾向评分回归分析来确定在拉丁美洲、非洲、西太平洋、东地中海和东南亚29个国家的359个卫生机构的严重贫血和孕产妇死亡之间的关系。严重贫血定义:围产期血色素低于70g/

在中低收入国家,贫血将近影响一半的妊娠女性,但该疾病的负担以及与妊娠死亡率的尚无可靠的定量化数据。Jahnavi Daru等人利用WHO多国家对孕产妇和新生儿健康的调查数据对重度贫血和孕产妇死亡之间的关系进行评估。

研究人员利用多层次和倾向评分回归分析来确定在拉丁美洲、非洲、西太平洋、东地中海和东南亚29个国家的359个卫生机构的严重贫血和孕产妇死亡之间的关系。严重贫血定义:围产期血色素低于70g/L。孕产妇死亡定义:入院后分娩后7天内死亡。在回归分析中,将产后出血、全身麻醉、重症监护、脓毒症、子痫前期和子痫、血小板减少、休克、大量输血、重度少尿、凝血障碍和重度酸中毒作为混杂变量进行校准。

校准的多重逻辑学分析纳入312281位入院进行分娩或异位妊娠的女性,倾向评分回归分析纳入12470位。与无重度贫血的女性相比,重度贫血的女性孕产期死亡的校准危险比 2.36(95% CI 1.60-3.48)。在倾向评分分析中,重度贫血也与孕产妇死亡相关(校准危险比 1.86[95% CI 1.39-2.49])。

预防和治疗妊娠期及产褥期贫血应仍是全球公共卫生和研究的重点。

原始出处:

Jahnavi Daru,et al.Risk of maternal mortality in women with severe anaemia during pregnancy and post partum: a multilevel analysis.The Lancet Global Health. March 20,2018.https://doi.org/10.1016/S2214-109X(18)30078-0

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    2018-09-10 仁医06
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    2018-05-12 shizhenshan
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