JACC:缺血性脑卒中的发生与吸食大麻是否有关?

2015-10-30 MedSci 译 MedSci原创

近日,最新一项医学研究成果表明,在患有缺血性中风的患者中,定期吸食大麻的患者比没有吸食过大麻的更容易出现颅内动脉狭窄。据统计,在 2005到2014年期间法国共有334名缺血性中风患者,其中58名有吸食大麻史的患者出现过颅内动脉狭窄症状。而对于无吸食大麻史的中风患者中,只有14.5%出现了颅内动脉狭窄的症状,这项研究结果具有重要的统计学意义。“目前,如何成功预防脑中风的发生在国际上依然是一个难以解

近日,最新一项医学研究成果表明,在患有缺血性中风的患者中,定期吸食大麻的患者比没有吸食过大麻的更容易出现颅内动脉狭窄。

据统计,在 2005到2014年期间法国共有334名缺血性中风患者,其中58名有吸食大麻史的患者出现过颅内动脉狭窄症状。而对于无吸食大麻史的中风患者中,只有14.5%出现了颅内动脉狭窄的症状,这项研究结果具有重要的统计学意义。

“目前,如何成功预防脑中风的发生在国际上依然是一个难以解决的问题。随着脑中风的发病人群逐渐年轻化,因此,年轻的成年人也应注意预防。”这是法国沃尔夫博士和他的同事于2015年11月3日发表在美国心脏病学会杂志上所提出的一个问题。“首先我们要告知公众脑中风的发生率与吸食大麻、生活方式以及目前世界范围内个别地方立法使用大麻有紧密的相关因素。

研究人员指出,在吸食大麻的脑中风患者当中,大多数是男性或平时有特殊行为习惯的人群,他们相对于那些不吸食大麻的脑中风患者显得更加地年轻。另外,沃尔夫博士和他的同事们指出,颅内潜在的动脉狭窄会显示出可逆的收缩和受损的脑线粒体呼吸,而这又会反过来引起患者对吸食大麻的兴趣。

据统计,在 276不定期吸食大麻者中,近1/3发生缺血性中风的主要病因是心源性栓塞。相反,在吸食大麻者中只有13.8%患缺血性中风的主要是病因是心源性栓塞。这个数据在临床研究上具有重要的统计学意义。

研究表明,当患者出现脑中风症状后,虽然吸食大麻的患者中大部分表现出视觉障碍的症状,而少数患者则出现了失语的症状,但是,吸食大麻的患者与非吸食大麻的患者整体表现的临床症状非常地类似。

“通过我们的研究数据,我们发现年轻的患者发生脑中风后吸食大麻,一般其神经系统生理功能的完整性都是良好的,而这有可能与患者的年龄有着密切的关系。”沃尔夫博士与其同事认为。但是,在整个研究中,我们发现有18%的患者出现了残疾,另有五人最终出现了死亡。


原始出处:

Wolff V, Zinchenko I, Quenardelle V, et al. Characteristics and prognosis of ischemic stroke in young cannabis users compared with non-cannabis users. J Am Coll Cardiol 2015; 66:2052-2053. 

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    2016-07-26 hbwxf
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    2015-11-01 kcb069
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