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Eur Respir J：频繁恶化的哮喘患者患病率、特征和管理

2018-08-04 xing.T MedSci原创

频繁恶化的哮喘患病率特征管理
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由此可见，频繁恶化的哮喘患者特征是年龄越大，女性较为常见，嗜酸性粒细胞和中性粒细胞计数较高，合并症的患病率也较高。通过制定针对严重哮喘的新治疗方案和确定这些患者的身份，以确保减少恶化。

近日，呼吸疾病领域权威杂志Eur Respir J上发表了一篇研究文章，该研究的目的是调查频繁恶化哮喘患者的患病率、管理和特征。

研究人员通过与瑞典国家健康登记处链接确定哮喘患者（年龄≥18岁）的初级保健医疗记录中的数据。哮喘恶化被定义为住院、急诊就诊和/或口服类固醇药物。哮喘频繁恶化被定义为在3年观察期内每年发生两次以上急性恶化。

在18724名哮喘患者中，81.49％的患者没有急性恶化，6.3％的患者在研究日期前一年内频繁恶化。1.8％的患者每年观察到频繁恶化。频繁的急性恶化者年龄较大，更常见于女性，并且与没有急性恶化的患者相比，嗜酸性粒细胞和中性粒细胞计数增加，肺功能降低，合并症更多。与基线相比，哮喘药物治疗略有增加，医生就诊次数略有下降，无论是在有无频繁恶化组都是如此。

由此可见，频繁恶化的哮喘患者特征是年龄越大，女性较为常见，嗜酸性粒细胞和中性粒细胞计数较高，合并症的患病率也较高。通过制定针对严重哮喘的新治疗方案和确定这些患者的身份，以确保减少恶化。

原始出处：

Christer Janson,et al. Prevalence, characteristics and management of frequently exacerbating asthma patients: an observational study in Sweden (PACEHR). Eur Respir J. 2018. http://erj.ersjournals.com/content/52/2/1701927

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    2019-05-28 feather78

    #频繁恶化的哮喘#

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    2018-08-06 xinmeili

    #患病率#

    0

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    2018-08-04 lietome24

    感谢小编为我们准备了如此丰盛的精神大餐，同时也向作者致谢！认真学习了，点赞！

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1820323, encodeId=69ac1820323ab, content=<a href='/topic/show?id=f0b4100e13f7' target=_blank style='color:#2F92EE;'>#频繁恶化的哮喘#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100713, encryptionId=f0b4100e13f7, topicName=频繁恶化的哮喘)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3679417, createdName=feather78, createdTime=Tue May 28 04:22:00 CST 2019, time=2019-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1250561, encodeId=48b812505610d, content=<a href='/topic/show?id=7d6f52988e1' target=_blank style='color:#2F92EE;'>#患病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52988, encryptionId=7d6f52988e1, topicName=患病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Mon Aug 06 06:22:00 CST 2018, time=2018-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336380, encodeId=fc2333638033, content=感谢小编为我们准备了如此丰盛的精神大餐，同时也向作者致谢！认真学习了，点赞！, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eb131638261, createdName=lietome24, createdTime=Sat Aug 04 15:39:04 CST 2018, time=2018-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336375, encodeId=5e443363e5ce, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ba101609906, createdName=happsf, createdTime=Sat Aug 04 15:29:44 CST 2018, time=2018-08-04, status=1, ipAttribution=)]
    2018-08-04 happsf

    学习

    0