JACC:动脉斑块体积和形态对心肌灌注量有明显的影响

2018-02-05 MedSci MedSci原创

动脉粥样硬化斑块的特性可能对下游的心肌灌注和冠脉损伤的严重程度有影响。本研究的目的旨在评估斑块的数量和形态对心肌灌注和血流储备分数(FFR)的影响。本研究纳入了208例(男性占63%,平均年龄为58 ± 8.7岁)疑似有冠心病的患者。所有患者通过冠状动脉造影(CTA)对斑块的数量和形态进行评估,并通过PET和侵入性FFR诊断措施对患者心肌灌注和FFR情况进行评估。最终发现有179名患者存在动脉粥样

动脉粥样硬化斑块的特性可能对下游的心肌灌注和冠脉损伤的严重程度有影响。本研究的目的旨在评估斑块的数量和形态对心肌灌注和血流储备分数(FFR)的影响。

本研究纳入了208例(男性占63%,平均年龄为58 ± 8.7岁)疑似有冠心病的患者。所有患者通过冠状动脉造影(CTA)对斑块的数量和形态进行评估,并通过PET和侵入性FFR诊断措施对患者心肌灌注和FFR情况进行评估。最终发现有179名患者存在动脉粥样硬化性斑块,以每条冠脉血管为对象,传统的冠脉斑块指数(包括斑块的长度和体积,最小管腔面积和梗阻率)与心肌血流量减少和FFR的降低呈相关性。此外,斑块的形态,比如部分钙化斑块、阳性重塑(PR)和低衰减斑块对心肌血流量是负面的影响因素。

研究结果显示,阳性重塑和大体积的动脉粥样硬化性斑块对心肌血流灌注和血流储备分数有不利的影响。

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    2018-02-15 hbwxf
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