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Science：研究人员发现雄性老鼠参与竞争优势的脑机制

2017-07-16 MedSci MedSci原创

雄性老鼠竞争优势脑机制
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浙大医学院胡海岚团队发现，雄性小鼠大脑中的一部分在与其他雄性老鼠的竞争优势中扮演着关键的角色。文章发表在《科学》杂志上，描述了小鼠脑部扫描、光遗传学和钻管测试实验。众所周知，老鼠是群居动物，先前的研究表明，支配地位在维持社会秩序、支配地位、建立等级制度等方面起到了作用，这有助于维持社区内的和平。虽然体格大小已被证明在小鼠的竞争优势地位中发挥作用，但先前的研究确定了一些行为因素，特别是耐力，发挥更大


浙大医学院胡海岚团队发现，雄性小鼠大脑中的一部分在与其他雄性老鼠的竞争优势中扮演着关键的角色。文章发表在《科学》杂志上，描述了小鼠脑部扫描、光遗传学和钻管测试实验。

众所周知，老鼠是群居动物，先前的研究表明，支配地位在维持社会秩序、支配地位、建立等级制度等方面起到了作用，这有助于维持社区内的和平。虽然体格大小已被证明在小鼠的竞争优势地位中发挥作用，但先前的研究确定了一些行为因素，特别是耐力，发挥更大的作用。在这项新的研究中，研究人员试图了解当雄性老鼠被迫进入一个竞争优势被鼓励的情境时，雄性老鼠的大脑变化情况。

实验包括监测老鼠的脑电波，进行标准优势测试。两只雄性老鼠被鼻子对鼻子的放置在一段只能让一只小鼠通过的玻璃管道中。唯一的出路就是其中一方认输，向后退到管子的尽头。这样，研究人员发现，背内侧前额叶皮质（DMPFC）更为活跃的老鼠，赢得这样的比赛。更具体地说，他们发现，当执行推、反推或抵抗动作时，dmPFC更活跃。相反，在撤退这样的活动中，同一个区域的活动弱势鼠不如优势鼠的活跃。

在对几只小鼠进行测试后，研究小组识别出哪些老鼠更占优势，然后通过给小鼠服用一种能使dmPFC安静的药物来抑制这种优势地位，这表明他们找到了负责控制优势地位的大脑的正确区域。然后，研究人员利用光遗传学来刺激dmPFC在不那么占优势地位的老鼠身上，并发现这样做会使劣势鼠成功逆袭--至少在光刺激停止后，这种效应持续了一整天。研究人员报告说，他们计划继续进行研究，以了解大脑的相同部位是否与雌性老鼠的竞争优势有关。

原文出处：Tingting Zhou, Hong Zhu, Zhengxiao Fan, et,al. History of winning remodels thalamo-PFC circuit to reinforce social dominance， Science  14 Jul 2017： Vol. 357， Issue 6347， pp. 162-168.

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    2017-08-11 chenlianhui

    #脑机制#

    0

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    2018-06-24 gostraight

    #研究人员#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2075589, encodeId=3fa420e558980, content=<a href='/topic/show?id=7e25848e5dd' target=_blank style='color:#2F92EE;'>#脑机制#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84875, encryptionId=7e25848e5dd, topicName=脑机制)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fa4f352, createdName=chenlianhui, createdTime=Fri Aug 11 10:37:00 CST 2017, time=2017-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1907489, encodeId=bc62190e48992, content=<a href='/topic/show?id=379fe3364c9' target=_blank style='color:#2F92EE;'>#研究人员#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73364, encryptionId=379fe3364c9, topicName=研究人员)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=db5b227, createdName=gostraight, createdTime=Sun Jun 24 15:37:00 CST 2018, time=2018-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=223534, encodeId=e139223534e6, content=很好，不错，以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Tue Jul 18 12:32:53 CST 2017, time=2017-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1375633, encodeId=51b213e56338a, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Tue Jul 18 01:37:00 CST 2017, time=2017-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=222953, encodeId=b325222953e7, content=非常好的文章，学习了，很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Sun Jul 16 15:36:49 CST 2017, time=2017-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=222899, encodeId=a233222899ce, content=在对几只小鼠进行测试后，研究小组识别出哪些老鼠更占优势，然后通过给小鼠服用一种能使dmPFC安静的药物来抑制这种优势地位，这表明他们找到了负责控制优势地位的大脑的正确区域。, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sun Jul 16 12:02:51 CST 2017, time=2017-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=222889, encodeId=743d22288947, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Sun Jul 16 11:09:12 CST 2017, time=2017-07-16, status=1, ipAttribution=)]
    2017-07-18 李东泽

    很好，不错，以后会多学习

    0

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    2017-07-18 jichang

    #SCIE#

    0

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    2017-07-16 天涯183

    非常好的文章，学习了，很受益

    0

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    2017-07-16 有备才能无患

    在对几只小鼠进行测试后，研究小组识别出哪些老鼠更占优势，然后通过给小鼠服用一种能使dmPFC安静的药物来抑制这种优势地位，这表明他们找到了负责控制优势地位的大脑的正确区域。

    0

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    2017-07-16 楠博One

    学习谢谢分享

    0