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Diabetologia：患有早发型2型糖尿病的成年人(18-39岁)在糖尿病临床研究试验中严重缺乏代表性？

2020-08-31 MedSci原创 MedSci原创

中国成人2型糖尿病HbA1c控制目标及达标策略的专家共识成人2型糖尿病
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成人2型糖尿病(诊断年龄在18岁到39岁之间) 早期发病越来越普遍，并显示出与不良的长期预后相关。研究人员假设早发性成人2型糖尿病患者在2型糖尿病管理指南的重要研究试验中没有足够的代表性。

成人2型糖尿病(诊断年龄在18岁到39岁之间) 早期发病越来越普遍，并显示出与不良的长期预后相关。研究人员假设早发性成人2型糖尿病患者在2型糖尿病管理指南的重要研究试验中没有足够的代表性。

研究人员回顾了参加90项2型糖尿病重要试验的研究人群的平均年龄，包括37项涉及一系列药理，非药理和多因素干预措施的心肾预后试验，以及来自三个代表血糖的III期计划的28项试验 -在临床实践中常规使用的降压疗法（依格列净，利拉鲁肽和西他列汀）和25项糖尿病自我管理教育和支持或密集生活方式干预（饮食或有监督的运动训练）的重要试验。然后研究人员估计了这些试验中年龄在18岁到39岁之间的个体数量。

研究结果表明，在所有90个试验中，268,978名参与者的平均年龄为63岁(个体试验的年龄范围为51-69岁)。在73个试验(81%)中，小于5%的参与者年龄估计在18-39岁，这个年龄组代表了~ 15-20%的成人2型糖尿病人群。其中29个试验(32%;共164,953名参与者)排除了年龄在40岁以下的人。

早期发病的成人2型糖尿病的指南主要是根据老年人的证据推断出来的。 必须采取策略支持早期发作的成人2型糖尿病患者参与未来的研究，以确保针对这些高危人群的指导方针是基于证据的。

原始出处：

Jack A. Sargeant, Emer M. Brady,Adults with early-onset type 2 diabetes (aged 18–39 years) are severely underrepresented in diabetes clinical research trials

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    2020-12-15 ms5439512287675881

    #BET#

    0

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    2020-11-04 ms9608593228839890

    #DIA#

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    2021-05-19 ms7258648636991762

    #早发#

    0

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    2020-10-14 ms2000000624889280

    我是早发型

    0

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    2020-09-01 不想取名

    谢谢分享

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1761500, encodeId=1f931e61500c1, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Tue Dec 15 07:44:02 CST 2020, time=2020-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1639592, encodeId=1a41163959204, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Wed Nov 04 13:44:02 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1664105, encodeId=79fd1664105e6, content=<a href='/topic/show?id=a20c59283e5' target=_blank style='color:#2F92EE;'>#早发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59283, encryptionId=a20c59283e5, topicName=早发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=06c425715601, createdName=ms7258648636991762, createdTime=Wed May 19 08:44:02 CST 2021, time=2021-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=891931, encodeId=504f891931ff, content=我是早发型, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=10535425256, createdName=ms2000000624889280, createdTime=Wed Oct 14 08:20:05 CST 2020, time=2020-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=881925, encodeId=16e1881925e7, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200826/93863e99dbdd47b7a8de6d0464a61901/e0c652961ab447f7aab5d63c6958a527.jpg, createdBy=28335287925, createdName=不想取名, createdTime=Tue Sep 01 22:56:03 CST 2020, time=2020-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=881617, encodeId=e1ab88161e72, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=64245268311, createdName=14818eb4m67暂无昵称, createdTime=Tue Sep 01 08:03:05 CST 2020, time=2020-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043306, encodeId=6458104330617, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Mon Aug 31 17:44:02 CST 2020, time=2020-08-31, status=1, ipAttribution=)]
    2020-09-01 14818eb4m67暂无昵称

    学习

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    2020-08-31 misszhang

    谢谢MedSci提供最新的资讯

    0

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