Hypertension:年龄和靶器官损伤对24小时动态血压预后价值的影响!

2017-09-15 MedSci MedSci原创

靶器官损伤的标志物以及24小时动态血压(BP)监测可以改善心血管的危险分层。随着年龄的增加,目标器官损伤和BP升高的流行性也增加。近期,一项发表在杂志Hypertension上的研究旨在评估年龄和靶器官损伤对动态血压的预后价值的影响。此项研究在1408名41岁或51岁(中年人群)以及61岁或71岁(老年人群)的健康人群中测量了目标器官损伤标志物和动态血压水平。主要研究结果是随访16年后的心血管事件

靶器官损伤的标志物以及24小时动态血压(BP)监测可以改善心血管的危险分层。随着年龄的增加,目标器官损伤和BP升高的流行性也增加。近期,一项发表在杂志Hypertension上的研究旨在评估年龄和靶器官损伤对动态血压的预后价值的影响。此项研究在1408名41岁或51岁(中年人群)以及61岁或71岁(老年人群)的健康人群中测量了目标器官损伤标志物和动态血压水平。主要研究结果是随访16年后的心血管事件,数据来自国家注册管理机构。使用Cox回归模型评估BP的预后价值,根据传统危险因素和靶器官损伤进行调整,包括左心室质量、脉搏波速度、颈动脉斑块和尿白蛋白/肌酐比。最终,共发生323起事件。与传统危险因素相比,收缩压增加和目标器官损伤的存在增加风险分层(一致性指数从0.711提高到0.728(P = 0.01))。与没有靶器官损伤的受试者相比,在具有靶器官损伤的中年受试者中,脉压(风险比,1.70;95%置信区间,1.31-2.21;P <0.01)和平均实际变异性增加(风险比,1.29;95%置信区间,1.05-1.59;P = 0.02)具有更大的心血管疾病风险:风险比,1.04(95

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    2018-08-15 chengjn
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topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Sun Sep 17 01:09:00 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508993, encodeId=275e15089936d, content=<a href='/topic/show?id=a7c83311e88' target=_blank style='color:#2F92EE;'>#动态血压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33117, encryptionId=a7c83311e88, topicName=动态血压)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2c1e10025437, createdName=limedical1977, createdTime=Sun Sep 17 01:09:00 CST 2017, time=2017-09-17, status=1, ipAttribution=)]
    2018-02-21 habb
  4. 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createdBy=447433741908, createdName=chengjn, createdTime=Wed Aug 15 17:09:00 CST 2018, time=2018-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2078436, encodeId=dfd020e843694, content=<a href='/topic/show?id=4d92999582c' target=_blank style='color:#2F92EE;'>#靶器官#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99958, encryptionId=4d92999582c, topicName=靶器官)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19c567, createdName=habb, createdTime=Wed Feb 21 01:09:00 CST 2018, time=2018-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2038750, encodeId=cc142038e50f4, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Tue Jul 03 02:09:00 CST 2018, time=2018-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1636423, encodeId=4938163642357, content=<a href='/topic/show?id=eb4810160a' target=_blank style='color:#2F92EE;'>#24小时动态血压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1016, encryptionId=eb4810160a, topicName=24小时动态血压)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fa9722636957, createdName=1508842480_96220444, createdTime=Sat Feb 24 11:09:00 CST 2018, time=2018-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1726725, encodeId=33b31e26725f1, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, 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encodeId=d8c9139e32195, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Sun Sep 17 01:09:00 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501202, encodeId=5c9015012026c, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Sun Sep 17 01:09:00 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508993, encodeId=275e15089936d, content=<a href='/topic/show?id=a7c83311e88' target=_blank style='color:#2F92EE;'>#动态血压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33117, encryptionId=a7c83311e88, topicName=动态血压)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2c1e10025437, createdName=limedical1977, createdTime=Sun Sep 17 01:09:00 CST 2017, time=2017-09-17, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1987030, encodeId=c55e198e03026, content=<a href='/topic/show?id=f4554029898' target=_blank style='color:#2F92EE;'>#器官损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40298, encryptionId=f4554029898, topicName=器官损伤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7770, createdName=jeanqiuqiu, createdTime=Tue Dec 12 19:09:00 CST 2017, time=2017-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1725266, encodeId=c9481e25266c5, content=<a href='/topic/show?id=e20b101402' target=_blank style='color:#2F92EE;'>#24小时#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1014, encryptionId=e20b101402, topicName=24小时)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=447433741908, createdName=chengjn, createdTime=Wed Aug 15 17:09:00 CST 2018, time=2018-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2078436, encodeId=dfd020e843694, content=<a href='/topic/show?id=4d92999582c' target=_blank style='color:#2F92EE;'>#靶器官#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99958, encryptionId=4d92999582c, topicName=靶器官)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19c567, createdName=habb, createdTime=Wed Feb 21 01:09:00 CST 2018, time=2018-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2038750, encodeId=cc142038e50f4, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Tue Jul 03 02:09:00 CST 2018, time=2018-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1636423, encodeId=4938163642357, content=<a href='/topic/show?id=eb4810160a' target=_blank style='color:#2F92EE;'>#24小时动态血压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1016, encryptionId=eb4810160a, topicName=24小时动态血压)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fa9722636957, createdName=1508842480_96220444, createdTime=Sat Feb 24 11:09:00 CST 2018, time=2018-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1726725, encodeId=33b31e26725f1, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Thu May 03 02:09:00 CST 2018, time=2018-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1385193, encodeId=c9c913851931d, content=<a href='/topic/show?id=dc121001e22d' target=_blank style='color:#2F92EE;'>#预后价值#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100172, encryptionId=dc121001e22d, topicName=预后价值)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=70fe497, createdName=paperyu, createdTime=Sun Sep 17 01:09:00 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397321, encodeId=d8c9139e32195, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Sun Sep 17 01:09:00 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501202, encodeId=5c9015012026c, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Sun Sep 17 01:09:00 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508993, encodeId=275e15089936d, content=<a href='/topic/show?id=a7c83311e88' target=_blank style='color:#2F92EE;'>#动态血压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33117, encryptionId=a7c83311e88, topicName=动态血压)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2c1e10025437, createdName=limedical1977, createdTime=Sun Sep 17 01:09:00 CST 2017, time=2017-09-17, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1987030, encodeId=c55e198e03026, content=<a href='/topic/show?id=f4554029898' target=_blank style='color:#2F92EE;'>#器官损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40298, encryptionId=f4554029898, topicName=器官损伤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7770, createdName=jeanqiuqiu, createdTime=Tue Dec 12 19:09:00 CST 2017, time=2017-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1725266, encodeId=c9481e25266c5, content=<a href='/topic/show?id=e20b101402' target=_blank style='color:#2F92EE;'>#24小时#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1014, encryptionId=e20b101402, topicName=24小时)], attachment=null, authenticateStatus=null, createdAvatar=null, 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objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Thu May 03 02:09:00 CST 2018, time=2018-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1385193, encodeId=c9c913851931d, content=<a href='/topic/show?id=dc121001e22d' target=_blank style='color:#2F92EE;'>#预后价值#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100172, encryptionId=dc121001e22d, topicName=预后价值)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=70fe497, createdName=paperyu, createdTime=Sun Sep 17 01:09:00 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397321, encodeId=d8c9139e32195, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Sun Sep 17 01:09:00 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501202, encodeId=5c9015012026c, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Sun Sep 17 01:09:00 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508993, encodeId=275e15089936d, content=<a href='/topic/show?id=a7c83311e88' target=_blank style='color:#2F92EE;'>#动态血压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33117, encryptionId=a7c83311e88, topicName=动态血压)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2c1e10025437, createdName=limedical1977, createdTime=Sun Sep 17 01:09:00 CST 2017, time=2017-09-17, status=1, ipAttribution=)]
    2018-05-03 feather89
  7. 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  8. 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  9. 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  10. 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Stroke:房颤抗凝有没有年龄限制?

随着预期寿命增加以及健康状况的改善,弄清更高龄患者采用抗凝治疗的安全性非常重要。因此,来自瑞典?rebro大学医院的Peter Appelros等在Stroke上发表了他们的研究结果,他们分析了4个国家综合登记研究的观察性数据(从2006年到2013年)共23356例合并AF的卒中患者,年龄介于80-100岁。第二个目的是为了验乞出血风险和常用药物之间的关系。

J Hypertens:正常脑血管搏动随年龄的变化及其对微血管病变的影响!

由此可见,老年患者脑微血管损伤是由于高脉动压力撕裂脆弱介质,造成出血,高脉搏波动流去除内皮细胞,导致血栓形成和微梗死。老年患者的脉搏波动是由下半身早期反射波所引起的。减少或延缓波反射是治疗老年人主动脉硬化的一种合乎逻辑的策略。

Int Arch Otorhinolaryngol:听觉言语感知发育与病人耳蜗移植的年龄相关

在习语前耳聋的青少年病人中的耳蜗移植到目前为止仍旧是个充满争议性的话题。最近,有研究人员分析和比较了接受耳蜗移植的习语前听力损失的儿童病人中,听觉言语感知的发育情况,该研究是在移植后第一年不同的年龄组中进行的。该研究是一个回顾性的、文献检索的研究,研究人员分析了有关患有严重双边感官听力损失和单边耳蜗移植使用者的78例报道。研究人员将研究群体分为三个组:G1,22名婴幼儿且年龄小于42个月;G2,2

Am J Obstet Gynecol:父亲年龄对妊娠结局的影响。

随着父母年龄的增长,推迟生育的趋势越来越明显。高龄产妇和辅助生殖技术的风险增加这一观点广为被接受。但关于高龄父亲的数据较少,为了能更好的提供优生优育咨询,应该加大对高龄父亲的研究。

JAMA:老年人冠状动脉钙化评分与年龄和心血管风险的关系

大家都知道年龄是动脉粥硬化性心血管疾病(ASCVD)重要的危险因素,而除了年龄以外,也需要在老年人中识别其他的危险因素。为了检测冠状动脉钙化(CAC)评分vs 年龄对ASCVD事件的预测能力以及加入CAC评分仅去除年龄后风险预测如何变化,Yuichiro Yano等人进行了相关研究,并将结果发表在近日的JAMA杂志上。

新华社:我国乳腺癌高发 年龄较西方年轻近20岁

中国抗癌协会乳腺癌专业委员会副主委、天津市肿瘤医院乳腺肿瘤三科主任张瑾说,乳腺癌的发病率已经高居女性恶性肿瘤之首,与欧美国家相比,我国乳腺癌发病年龄高峰位于45-50岁。