Sci Rep:糖尿病患者视网膜神经纤维层缺损可能与系统性血管状态有关!

2018-07-17 佚名 中国医学论坛报今日糖尿病

近日,一项在线发表于《Nature》杂志上的韩国研究表明: 2型糖尿病患者的视网膜神经纤维层(RNFL)缺损与其系统性血管状态有关。

近日,一项在线发表于《Nature》杂志上的韩国研究表明: 2型糖尿病患者的视网膜神经纤维层(RNFL)缺损与其系统性血管状态有关。

临床中,不论2型糖尿病患者是否伴有糖尿病视网膜病变,RNFL缺损均是糖尿病患者的常见并发症之一。非青光眼性RNFL缺损与糖尿病患者系统性特征之间的关系,从多个层面引发了众多研究者的兴趣。

韩国加图里大学和韩国玛丽医院的研究者们,探索了糖尿病患者的RNFL缺损与患者系统血管状态之间的关系。

研究共纳入2型糖尿病患者167例,这些患者均接受了动脉硬化评估,并通过心率变异性(HRV)指标评估了其心血管自主神经功能。动脉硬化主要通过心踝血管指数(CAVI)和臂-踝指数(ABI)来测量。同时,研究者运用多因素回归分析方法,评估了影响RNFL缺损的基于年龄的因素,并探索了导致优越位置(superior location)的糖尿病性RNFL缺损的因素。

图  基于年龄分组的动脉硬化指数的比较



研究结果显示:CAVI在RNFL缺损的患者中表现的更差,特别是在年龄≥50岁的老年人群中(P=0.037);ABI也是影响老年患者RNFL缺损的重要因素 。

尽管如此,在年龄<50岁的年轻患者中,HRV参数(低频/高频比)决定了RNFL缺损是否出现(P=0.040)。

同时,研究还显示,CAVI和ABI是老年患者出现优越位置RNFL缺损的具有显著意义的决定性因素(P=0.032和P=0.024)。

这一结果提示,对于年轻的糖尿病患者,自主神经功能可能和RNFL缺损有关。但当糖尿病患者逐渐衰老时,则是动脉硬化在加剧血管自主调节功能的下降和糖尿病性RNFL缺损。

研究者最后总结,在糖尿病患者中,RNFL缺损也许与患者的全身性血管状态相关。 

原始出处:

Soo Ji Jeon, Hae-Young Lopilly Park, Jae Hyung Lee, et.al. Relationship between Systemic Vascular Characteristics and Retinal Nerve Fiber Layer Loss in Patients with Type 2 Diabetes. Scientific Reportsvolume 8, Article number: 10510 (2018)

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    2019-02-12 amyloid
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    2018-07-19 惠映实验室

    学习了,谢谢分享。

    0

  5. 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    2018-07-19 zutt
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GetPortalCommentsPageByObjectIdResponse(id=1041715, encodeId=db9f1041e15b1, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Tue Jul 17 15:47:00 CST 2018, time=2018-07-17, status=1, ipAttribution=)]
  8. 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encodeId=2eac3325225f, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Wed Jul 18 19:10:17 CST 2018, time=2018-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332265, encodeId=c8af33226550, content=了解一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Tue Jul 17 18:53:00 CST 2018, time=2018-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1041715, encodeId=db9f1041e15b1, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Tue Jul 17 15:47:00 CST 2018, time=2018-07-17, status=1, ipAttribution=)]
    2018-07-18 惠映实验室

    学习了谢谢分享

    0

  9. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Thu Jul 19 03:47:00 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1489757, encodeId=79e51489e57f2, content=<a href='/topic/show?id=5293e447259' target=_blank style='color:#2F92EE;'>#神经纤维#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74472, encryptionId=5293e447259, topicName=神经纤维)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=53f28597470, createdName=stfoxst, createdTime=Thu Jul 19 03:47:00 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332522, encodeId=2eac3325225f, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Wed Jul 18 19:10:17 CST 2018, time=2018-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332265, encodeId=c8af33226550, content=了解一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Tue Jul 17 18:53:00 CST 2018, time=2018-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1041715, encodeId=db9f1041e15b1, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Tue Jul 17 15:47:00 CST 2018, time=2018-07-17, status=1, ipAttribution=)]
    2018-07-17 天地飞扬

    了解一下谢谢分享

    0

  10. 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GetPortalCommentsPageByObjectIdResponse(id=1041715, encodeId=db9f1041e15b1, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Tue Jul 17 15:47:00 CST 2018, time=2018-07-17, status=1, ipAttribution=)]
    2018-07-17 misszhang

    谢谢MedSci提供最新的资讯

    0

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由此可见,在绝经后期女性中,较低的OC和CTX水平与基线胰岛素抵抗的风险增加相关,并且关联程度相似,并且与长期随访中糖尿病发生有关。进一步研究描述异常骨稳态和能量代谢之间相关性的机制可能揭示预防这些与年龄相关的疾病的新方法。

GUT:虫草多糖通过调节肠道菌群变化改善肥胖及II型糖尿病小鼠症状

研究认为虫草多糖以及P.goldsteinii肠杆菌具有治疗肥胖及II型糖尿病的潜力

Diabetes:清华大学李蓬院士揭示治疗肥胖的潜在新策略

代谢的平衡是靠组织、器官、细胞器和众多分子共同作用来维持的。Cidea和Cidec都是脂滴相关蛋白,能够分别促进棕色和白色脂肪组织进行脂质存储,之前许多研究对Cidea和Cidec参与肥胖发生的作用机制进行了研究。最近来自清华大学的李蓬院士课题组又对Cidea和Cidec如何参与机体能量消耗进行了更进一步研究,相关研究结果发表在国际学术期刊Didabetes上。

JAHA:急性冠状动脉综合征的糖尿病患者冠状动脉斑块特征

与非DM患者相比,DM患者在病变和非病变部位具有更多的脆弱特征,从而表现出更高水平的血管不稳定。