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JAMA Neurol：睡眠呼吸障碍与认知障碍风险

2017-09-02 zhangfan MedSci原创

睡眠呼吸障碍认知障碍老年人群
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研究认为睡眠呼吸障碍增加老年人群认知障碍风险，小幅影响患者的执行能力

越来越多的研究表明老年人群睡眠呼吸障碍性疾病(SDB)与认知功能减退相关。近日研究人员对二者之间的关系进行了系统性研究。

研究人员收集了截至2017年1月相关研究报道，包括横断面和前瞻性研究，入选试验至少有200名参与者，参与者平均年龄为40岁或以上。研究利用随机效应模型从横断面研究和前瞻性研究中提取和汇集调整后的风险比率。该荟萃分析遵循PRISMA和MOOSE 指南。

共14项研究纳入本次荟萃分析，包含4288419名参与者。对其中的6项前瞻性研究的汇总分析发现，SDB患者其认知功能障碍的风险提高了26%(rr，1.26；95%，CI，1.05-1.50)，排除1项异常结果后，SDB患者罹患认知障碍风险上升为1.35(95% CI，1.11-1.65)。对7项横断面研究进行汇总后发现，老年SDB患者执行功能稍差(标准平均差异-0.05； 95% CI， -0.09 —0.00)，但睡眠呼吸障碍与整体认知或记忆衰退无关。

研究认为睡眠呼吸障碍增加老年人群认知障碍风险，小幅影响患者的执行能力。

原始出处：


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    2019-03-20 牛逼闪闪

    学习了

    0

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    2018-03-22 bbwznl

    #呼吸障碍#

    0

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    2018-03-03 zhanfl

    #睡眠呼吸#

    0

  4. 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encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Tue May 08 11:19:00 CST 2018, time=2018-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=246634, encodeId=33b1246634e7, content=未来的发展前景广阔, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Sep 22 13:09:45 CST 2017, time=2017-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245469, encodeId=12d32454695d, content=内容丰富.值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], 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style='color:#2F92EE;'>#睡眠呼吸障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72996, encryptionId=41b2e2996be, topicName=睡眠呼吸障碍)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKQBvJI9WesEs5nl29JIJ7mAquShibzBHQmTeHHwZMDlIzc5qoQUhTJOpOwiaxYa9UcibrZviaM7dL7aQ/132, createdBy=35cb2500499, createdName=ms1343860338762272, createdTime=Mon Sep 04 01:19:00 CST 2017, time=2017-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240119, encodeId=f4d424011996, content=谢谢.学习中-!, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Sep 03 22:45:13 CST 2017, time=2017-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239868, encodeId=926723986824, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xjZ9qh3bhXrJtUlmycKGfQKPuADVZQsdNAQj5IrHHlzbGsDwScictBgogYRk8KhicpgEKwTEfOHgqw/0, createdBy=bc931611963, createdName=jin321, createdTime=Sun Sep 03 00:41:08 CST 2017, time=2017-09-03, status=1, ipAttribution=)]
    2018-05-08 yinhl1978

    #Neurol#

    0

  5. 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createdName=虈亣靌, createdTime=Sun Sep 03 22:45:13 CST 2017, time=2017-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239868, encodeId=926723986824, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xjZ9qh3bhXrJtUlmycKGfQKPuADVZQsdNAQj5IrHHlzbGsDwScictBgogYRk8KhicpgEKwTEfOHgqw/0, createdBy=bc931611963, createdName=jin321, createdTime=Sun Sep 03 00:41:08 CST 2017, time=2017-09-03, status=1, ipAttribution=)]
    2017-09-22 虈亣靌

    未来的发展前景广阔

    0

  6. 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style='color:#2F92EE;'>#睡眠呼吸障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72996, encryptionId=41b2e2996be, topicName=睡眠呼吸障碍)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKQBvJI9WesEs5nl29JIJ7mAquShibzBHQmTeHHwZMDlIzc5qoQUhTJOpOwiaxYa9UcibrZviaM7dL7aQ/132, createdBy=35cb2500499, createdName=ms1343860338762272, createdTime=Mon Sep 04 01:19:00 CST 2017, time=2017-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240119, encodeId=f4d424011996, content=谢谢.学习中-!, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Sep 03 22:45:13 CST 2017, time=2017-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239868, encodeId=926723986824, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xjZ9qh3bhXrJtUlmycKGfQKPuADVZQsdNAQj5IrHHlzbGsDwScictBgogYRk8KhicpgEKwTEfOHgqw/0, createdBy=bc931611963, createdName=jin321, createdTime=Sun Sep 03 00:41:08 CST 2017, time=2017-09-03, status=1, ipAttribution=)]
    2017-09-18 虈亣靌

    内容丰富.值得学习

    0

  7. 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encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Tue May 08 11:19:00 CST 2018, time=2018-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=246634, encodeId=33b1246634e7, content=未来的发展前景广阔, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Sep 22 13:09:45 CST 2017, time=2017-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245469, encodeId=12d32454695d, content=内容丰富.值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Mon Sep 18 23:38:55 CST 2017, time=2017-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241178, encodeId=2e272411e85f, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Wed Sep 06 22:55:30 CST 2017, time=2017-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1345575, encodeId=8d6613455e589, content=<a href='/topic/show?id=41b2e2996be' target=_blank style='color:#2F92EE;'>#睡眠呼吸障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72996, encryptionId=41b2e2996be, topicName=睡眠呼吸障碍)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKQBvJI9WesEs5nl29JIJ7mAquShibzBHQmTeHHwZMDlIzc5qoQUhTJOpOwiaxYa9UcibrZviaM7dL7aQ/132, createdBy=35cb2500499, createdName=ms1343860338762272, createdTime=Mon Sep 04 01:19:00 CST 2017, time=2017-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240119, encodeId=f4d424011996, content=谢谢.学习中-!, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Sep 03 22:45:13 CST 2017, time=2017-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239868, encodeId=926723986824, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xjZ9qh3bhXrJtUlmycKGfQKPuADVZQsdNAQj5IrHHlzbGsDwScictBgogYRk8KhicpgEKwTEfOHgqw/0, createdBy=bc931611963, createdName=jin321, createdTime=Sun Sep 03 00:41:08 CST 2017, time=2017-09-03, status=1, ipAttribution=)]
    2017-09-06 虈亣靌

    学习一下谢谢分享

    0

  8. 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encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Tue May 08 11:19:00 CST 2018, time=2018-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=246634, encodeId=33b1246634e7, content=未来的发展前景广阔, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Sep 22 13:09:45 CST 2017, time=2017-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245469, encodeId=12d32454695d, content=内容丰富.值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], 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createdName=虈亣靌, createdTime=Sun Sep 03 22:45:13 CST 2017, time=2017-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239868, encodeId=926723986824, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xjZ9qh3bhXrJtUlmycKGfQKPuADVZQsdNAQj5IrHHlzbGsDwScictBgogYRk8KhicpgEKwTEfOHgqw/0, createdBy=bc931611963, createdName=jin321, createdTime=Sun Sep 03 00:41:08 CST 2017, time=2017-09-03, status=1, ipAttribution=)]
    2017-09-04 ms1343860338762272

    #睡眠呼吸障碍#

    0

  9. 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createdName=虈亣靌, createdTime=Sun Sep 03 22:45:13 CST 2017, time=2017-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239868, encodeId=926723986824, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xjZ9qh3bhXrJtUlmycKGfQKPuADVZQsdNAQj5IrHHlzbGsDwScictBgogYRk8KhicpgEKwTEfOHgqw/0, createdBy=bc931611963, createdName=jin321, createdTime=Sun Sep 03 00:41:08 CST 2017, time=2017-09-03, status=1, ipAttribution=)]
    2017-09-03 虈亣靌

    谢谢.学习中-!

    0

  10. 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