盘点:2018年3月第1期BMJ研究精选

2018-03-02 zhangfan MedSci原创

BMJ

2018年3月第一期BMJ研究精选



【1】封面文章--如何优化夜班睡眠


夜班工作的辛苦不言而喻,但对于医疗工作者却是家常便饭。研究发现在午夜3-5点,人警觉性、认知功能、心理运动协调和情绪均达到最低点。夜班后,工作者必需打破昼夜节律进行休息,可导致慢性睡眠障碍。最近的一项系统研究发现夜班工作与睡眠不足、职业事故、肥胖、体重增加、2型糖尿病、冠心病、乳腺癌、前列腺癌和结直肠癌的风险增加相关。2007年,一项2231名英国实习麻醉师参与的研究发现,超过70%的实习医生认为夜班疲劳影响了身心健康。

近日诊疗心理学家Vicki Culpin 的新作强调每晚睡眠少于7个小时是对我们身心健康的一种灾难。在众多的发达国家中,失眠成为一种流行病,导致抑郁症、焦虑、痴呆、中风、心脏病、肥胖、癌症、糖尿病和道路交通事故风险增加

睡眠不足长期以来一直是医生的标签之一。研究发现疲劳是导致错误和决策失误的主要危险因素,而且人们不善于评估自己的疲劳程度。特别是医生更应该对自身的疲劳程度进行充分评估。好消息是目前部分医院要求医生在连续工作4小时后必需休息1小时。

对于必需进行夜班工作的人群而言,如何尽量减少夜班工作造成的睡眠负担是十分重要的,夜班期间规律计划性的休息目前是提高夜间工作效率,减少错误的最有效方法。

【2】积极监控而非干预是应对2级宫颈上皮内瘤变的最佳方法


近日研究人员对2级宫颈上皮内瘤变(CIN2)保守治疗后病情进展情况进行系统综述和荟萃分析考察。

研究对1973-2016年间相关研究资料进行考察,非妊娠妇女经组织学证实的CIN 2患者参与研究,患者接受三个月或更长时间的保守治疗。研究终点是不同随访时间的病情变化。

36个研究,3160名患者参与。24个月后,累积50%的患者病情自行恢复,32%的患者病情持续,18%的患者出现进展。对1069名30岁以下患者亚组分析发现,患者病情自行恢复、持续或进展比例分别为60%、23%以及11%。

研究认为,大部分2级宫颈上皮内瘤变可自行恢复,特别是对于30岁以下女性,积极监控而非干预是应对宫颈上皮内瘤变的最佳方法。

【3】年龄相关的计划外二次住院风险研究


近日研究人员对年龄相关的二次住院风险及趋势进行了回顾性分析。

研究人员考察了2013年起,31729762例住院病历索引,研究的主要终点为出院后30天内,全因非计划内的二次住院事件,对性别、支付方式、住院时间、出院处理、慢性病、入院原因和严重程度以及医院的数据进行调整,采用45岁作为参考年龄组。

研究发现,总计计划外30天二次住院率为11.6%,总计3678018例。以45岁为参考,16-20岁人群的二次住院率有先前的0.70,上升至1.04;21-44岁人群由先前的1.02上升至1.12;而46-64岁人群由先前的1.02下降至0.91,而65岁以上人群则大幅下降至0.78。在所有年龄组中,多种慢性疾病与调整后的二次入院风险相关性最高,对于6种以上慢性病人群其二次入院风险较无慢性病人群上升3.67倍。在儿童、青年以及中年人群中,心理健康因素是最常见的二次入院治疗因素(≥75%)。

研究认为,儿童及中青年人群计划外二次住院风险增加,而慢性病人群的二次住院风险最高。

【4】认识腹部偏头痛


腹部偏头痛是儿童反复腹痛的一个重要、常见且认识不足的原因,其与多种其他形式的偏头痛相关,并导致成人后偏头痛风险增加。

腹部偏头痛的症状及特征如下:

1、腹部偏头痛是发作性中心性腹痛,伴有其他偏头痛症状,尤其是周期性呕吐和肢体疼痛性偏头痛;

2、腹部偏头痛通常始于儿童时期,也可能发生在成人身上,患者常见有偏头痛家族史,成长发育期发病率最高;

3、腹部偏头痛是一项临床诊断阳性的疾病,经检查腹内无器质性病变后,就不需要进一步治疗;

4、腹部偏头痛机制不明,麦角胺类及β-受体阻断剂治疗可缓解患者症状。

【5】多发性急性减压性骨坏死病例


病例如下:

一位32岁的职业潜水员出现了6个月的下肢、右肩和肘关节疼痛史。在过去的十年里,患者在深度超过30米的水域进行了3000次潜水,并多次接受减压病治疗。磁共振成像显示患者股骨骨骺和骨干部分和右侧肱骨出现非均匀性梗死。

患者诊断为急性减压性骨坏死,一种被认为是由高压氧暴露后氮栓塞引起的骨坏死。减压性骨坏死通常发生在长骨近端,但本案中远端受累是不常见的,其危险因素包括年龄增加、肥胖、潜水深度和持续时间的延长以及高压氧治疗的延迟。治疗手段包括固定、植骨和关节置换,但预防和早期诊断是减少该疾病的主要方法。

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  1. 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createdName=惠映实验室, createdTime=Sat Mar 03 09:28:53 CST 2018, time=2018-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292492, encodeId=18c22924923f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/01/15/8213228fe923915543544ad3da7e1c64.jpg, createdBy=6bd82014262, createdName=秀红, createdTime=Sat Mar 03 07:44:22 CST 2018, time=2018-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292400, encodeId=0146292400bd, content=学习了感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Mar 02 23:46:39 CST 2018, time=2018-03-02, status=1, ipAttribution=)]
    2018-10-24 gaoxiaoe
  2. 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    2018-03-18 Anne0711

    统计数据显示有道理

    0

  3. 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createdName=Anne0711, createdTime=Sun Mar 18 15:54:18 CST 2018, time=2018-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=296836, encodeId=d96e296836a5, content=看到这里突然怀疑之前2个不明原因腹痛的孩子所有检查都做完了一切正常就是腹痛.可能就是这个.还怀疑人家癔症发作.真是汗颜呐, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=10702294153, createdName=121f181dm78暂无昵称, createdTime=Fri Mar 16 17:10:06 CST 2018, time=2018-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=294598, encodeId=23db29459803, content=不错.谢谢分享.很好用, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/17/cfa76f1048392033b44c71e9bcb628d9.jpg, createdBy=096c2156900, 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createdBy=4b2c1959822, createdName=雅文博武, createdTime=Sun Mar 04 07:04:19 CST 2018, time=2018-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292758, encodeId=d12c292e589a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f22260741, createdName=121832a9m88暂无昵称, createdTime=Sun Mar 04 06:23:31 CST 2018, time=2018-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292552, encodeId=61c0292552d9, content=学习.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sat Mar 03 09:28:53 CST 2018, time=2018-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292492, encodeId=18c22924923f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/01/15/8213228fe923915543544ad3da7e1c64.jpg, createdBy=6bd82014262, createdName=秀红, createdTime=Sat Mar 03 07:44:22 CST 2018, time=2018-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292400, encodeId=0146292400bd, content=学习了感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Mar 02 23:46:39 CST 2018, time=2018-03-02, status=1, ipAttribution=)]
    2018-03-16 121f181dm78暂无昵称

    看到这里突然怀疑之前2个不明原因腹痛的孩子所有检查都做完了一切正常就是腹痛.可能就是这个.还怀疑人家癔症发作.真是汗颜呐

    0

  4. 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createdName=梦想起航ing, createdTime=Fri Mar 09 20:29:37 CST 2018, time=2018-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=293015, encodeId=f212293015f7, content=不错学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/17/cfa76f1048392033b44c71e9bcb628d9.jpg, createdBy=096c2156900, createdName=梦想起航ing, createdTime=Sun Mar 04 23:04:41 CST 2018, time=2018-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292780, encodeId=f6a4292e80b7, content=学习了很多先进的医学知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161027/IMG58114E1818EA51495.jpg, createdBy=4b2c1959822, createdName=雅文博武, createdTime=Sun Mar 04 07:04:19 CST 2018, time=2018-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292758, encodeId=d12c292e589a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f22260741, createdName=121832a9m88暂无昵称, createdTime=Sun Mar 04 06:23:31 CST 2018, time=2018-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292552, encodeId=61c0292552d9, content=学习.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sat Mar 03 09:28:53 CST 2018, time=2018-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292492, encodeId=18c22924923f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/01/15/8213228fe923915543544ad3da7e1c64.jpg, createdBy=6bd82014262, createdName=秀红, createdTime=Sat Mar 03 07:44:22 CST 2018, time=2018-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292400, encodeId=0146292400bd, content=学习了感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Mar 02 23:46:39 CST 2018, time=2018-03-02, status=1, ipAttribution=)]
    2018-03-09 梦想起航ing

    不错.谢谢分享.很好用

    0

  5. 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createdName=梦想起航ing, createdTime=Fri Mar 09 20:29:37 CST 2018, time=2018-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=293015, encodeId=f212293015f7, content=不错学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/17/cfa76f1048392033b44c71e9bcb628d9.jpg, createdBy=096c2156900, createdName=梦想起航ing, createdTime=Sun Mar 04 23:04:41 CST 2018, time=2018-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292780, encodeId=f6a4292e80b7, content=学习了很多先进的医学知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161027/IMG58114E1818EA51495.jpg, createdBy=4b2c1959822, createdName=雅文博武, createdTime=Sun Mar 04 07:04:19 CST 2018, time=2018-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292758, encodeId=d12c292e589a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f22260741, createdName=121832a9m88暂无昵称, createdTime=Sun Mar 04 06:23:31 CST 2018, time=2018-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292552, encodeId=61c0292552d9, content=学习.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sat Mar 03 09:28:53 CST 2018, time=2018-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292492, encodeId=18c22924923f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/01/15/8213228fe923915543544ad3da7e1c64.jpg, createdBy=6bd82014262, createdName=秀红, createdTime=Sat Mar 03 07:44:22 CST 2018, time=2018-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292400, encodeId=0146292400bd, content=学习了感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Mar 02 23:46:39 CST 2018, time=2018-03-02, status=1, ipAttribution=)]
    2018-03-04 梦想起航ing

    不错学习了.谢谢分享

    0

  6. 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createdName=惠映实验室, createdTime=Sat Mar 03 09:28:53 CST 2018, time=2018-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292492, encodeId=18c22924923f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/01/15/8213228fe923915543544ad3da7e1c64.jpg, createdBy=6bd82014262, createdName=秀红, createdTime=Sat Mar 03 07:44:22 CST 2018, time=2018-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292400, encodeId=0146292400bd, content=学习了感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Mar 02 23:46:39 CST 2018, time=2018-03-02, status=1, ipAttribution=)]
    2018-03-04 雅文博武

    学习了很多先进的医学知识

    0

  7. 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createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Mar 02 23:46:39 CST 2018, time=2018-03-02, status=1, ipAttribution=)]
    2018-03-04 121832a9m88暂无昵称

    学习了

    0

  8. 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createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Mar 02 23:46:39 CST 2018, time=2018-03-02, status=1, ipAttribution=)]
    2018-03-03 惠映实验室

    学习.谢谢分享.

    0

  9. 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createdName=惠映实验室, createdTime=Sat Mar 03 09:28:53 CST 2018, time=2018-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292492, encodeId=18c22924923f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/01/15/8213228fe923915543544ad3da7e1c64.jpg, createdBy=6bd82014262, createdName=秀红, createdTime=Sat Mar 03 07:44:22 CST 2018, time=2018-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292400, encodeId=0146292400bd, content=学习了感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Mar 02 23:46:39 CST 2018, time=2018-03-02, status=1, ipAttribution=)]
    2018-03-03 秀红

    学习了

    0

  10. 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createdName=Anne0711, createdTime=Sun Mar 18 15:54:18 CST 2018, time=2018-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=296836, encodeId=d96e296836a5, content=看到这里突然怀疑之前2个不明原因腹痛的孩子所有检查都做完了一切正常就是腹痛.可能就是这个.还怀疑人家癔症发作.真是汗颜呐, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=10702294153, createdName=121f181dm78暂无昵称, createdTime=Fri Mar 16 17:10:06 CST 2018, time=2018-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=294598, encodeId=23db29459803, content=不错.谢谢分享.很好用, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/17/cfa76f1048392033b44c71e9bcb628d9.jpg, createdBy=096c2156900, 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    2018-03-02 虈亣靌

    学习了感谢分享

    0

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