IBD: 炎症性肠病患者出院后静脉血栓栓塞的风险

2020-10-25 MedSci原创 MedSci原创

住院期间,炎症性肠病(IBD)与静脉血栓栓塞(VTE)的高风险有关。目前尚不清楚这种关联在出院后是否仍然存在。我们旨在评估IBD患者出院后VTE的发生率,并确定IBD是否与增加的VTE风险相关。

背景及目的:

住院期间,炎症性肠病(IBD)与静脉血栓栓塞(VTE)的高风险有关。目前尚不清楚这种关联在出院后是否仍然存在。我们旨在评估IBD患者出院后VTE的发生率,并确定IBD是否与增加的VTE风险相关。

 

方法:

研究人员在2002年至2016年之间进行了基于人群的队列研究。将住院(≥72小时)的IBD成人分为非手术和手术队列,并在倾向评分上与非IBD对照相匹配。出院后VTE的时间通过Kaplan-Meier方法进行评估,VTE风险通过Cox比例风险模型进行评估。

 

 

结果:

共有81900例IBD出院患者(62848例非手术和19052例手术)与非IBD对照患者相匹配。非手术型IBD患者出院后12个月VTE的累积发生率为2.3%,而手术型IBD患者为1.6%。非手术IBD队列的发病率每年增加4%(OR,1.04; 95%CI,1.02-1.05)。在我们的倾向评分匹配分析中,非手术IBD患者([HR],1.72; 95%CI,1.51-1.96)和溃疡性结肠炎的手术患者(HR,1.68 ; 95%CI,1.16-2.45)在出院后1个月时发生VTE的风险较高。

 

 

结论:

非手术IBD患者和溃疡性结肠炎手术患者发生出院后VTE的可能性是非IBD患者的1.7倍。这些发现支持在该人群中提高警惕和考虑预防血栓的必要性。

 

原始出处:

Jeffrey D McCurdy. Et al. Risk of Venous Thromboembolism After Hospital Discharge in Patients With Inflammatory Bowel Disease: A Population-based Study. Inflammatory Bowel Diseases.2020.

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    2021-09-09 fusion
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    2021-06-14 xue8602
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    2020-10-27 bnurmamat
  5. [GetPortalCommentsPageByObjectIdResponse(id=1698157, encodeId=d7e9169815eca, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Thu Sep 09 11:14:57 CST 2021, time=2021-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=949371, encodeId=ac059493e1a1, content=<a href='/topic/show?id=18911042085d' target=_blank style='color:#2F92EE;'>#IBD血栓栓塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104208, encryptionId=18911042085d, topicName=IBD血栓栓塞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d74a5264746, createdName=1480d52fm40(暂无昵称), createdTime=Thu Mar 18 22:42:14 CST 2021, time=2021-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1955514, encodeId=7b8819555146b, content=<a href='/topic/show?id=0aeb991e44c' target=_blank style='color:#2F92EE;'>#静脉血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99174, encryptionId=0aeb991e44c, topicName=静脉血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, createdName=xue8602, createdTime=Mon Jun 14 08:14:57 CST 2021, time=2021-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1263613, encodeId=2c8112636132c, content=<a href='/topic/show?id=75bc930217' target=_blank style='color:#2F92EE;'>#IBD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9302, encryptionId=75bc930217, topicName=IBD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc0372, createdName=bnurmamat, createdTime=Tue Oct 27 02:14:57 CST 2020, time=2020-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547392, encodeId=0b6a154e392d8, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Tue Oct 27 02:14:57 CST 2020, time=2020-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1600078, encodeId=a08a16000e8c4, content=<a href='/topic/show?id=508e6e03203' target=_blank style='color:#2F92EE;'>#炎症性肠病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67032, encryptionId=508e6e03203, topicName=炎症性肠病患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a9fa18776644, createdName=huangshifeng, createdTime=Tue Oct 27 02:14:57 CST 2020, time=2020-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894279, encodeId=1fc08942e9e7, content=受益匪浅,谢谢!, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e10d2265523, createdName=陆梓文, createdTime=Sun Oct 25 11:40:34 CST 2020, time=2020-10-25, status=1, ipAttribution=)]
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  7. [GetPortalCommentsPageByObjectIdResponse(id=1698157, encodeId=d7e9169815eca, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Thu Sep 09 11:14:57 CST 2021, time=2021-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=949371, encodeId=ac059493e1a1, content=<a href='/topic/show?id=18911042085d' target=_blank style='color:#2F92EE;'>#IBD血栓栓塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104208, encryptionId=18911042085d, topicName=IBD血栓栓塞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d74a5264746, createdName=1480d52fm40(暂无昵称), createdTime=Thu Mar 18 22:42:14 CST 2021, time=2021-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1955514, encodeId=7b8819555146b, content=<a href='/topic/show?id=0aeb991e44c' target=_blank style='color:#2F92EE;'>#静脉血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99174, encryptionId=0aeb991e44c, topicName=静脉血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, createdName=xue8602, createdTime=Mon Jun 14 08:14:57 CST 2021, time=2021-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1263613, encodeId=2c8112636132c, content=<a href='/topic/show?id=75bc930217' target=_blank style='color:#2F92EE;'>#IBD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9302, encryptionId=75bc930217, topicName=IBD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc0372, createdName=bnurmamat, createdTime=Tue Oct 27 02:14:57 CST 2020, time=2020-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547392, encodeId=0b6a154e392d8, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Tue Oct 27 02:14:57 CST 2020, time=2020-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1600078, encodeId=a08a16000e8c4, content=<a href='/topic/show?id=508e6e03203' target=_blank style='color:#2F92EE;'>#炎症性肠病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67032, encryptionId=508e6e03203, topicName=炎症性肠病患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a9fa18776644, createdName=huangshifeng, createdTime=Tue Oct 27 02:14:57 CST 2020, time=2020-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894279, encodeId=1fc08942e9e7, content=受益匪浅,谢谢!, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e10d2265523, createdName=陆梓文, createdTime=Sun Oct 25 11:40:34 CST 2020, time=2020-10-25, status=1, ipAttribution=)]
    2020-10-25 陆梓文

    受益匪浅,谢谢!

    0

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