Kidney int:腹膜透析与血液透析相比,哪个对认知功能的改善更好?

2017-10-22 MedSci MedSci原创

终末期肾病患者的认知功能受损可能会降低其遵守复杂的医疗程序或饮食方案以及充分参与医疗决策的能力。随着肾功能的降低,患者的认知能力可能也下降,开始透析后认知功能的障碍可能会发生改善,肾移植成功后的患者其认识功能障碍甚至可以出现逆转。然而,目前关于这些患者的认知功能变化知之甚少,特别是关于不同的治疗方式对认知功能的影响。为了进一步了解这一点,近期,一篇发表在杂志Kidney int上的文章进行了为期一

终末期肾病患者的认知功能受损可能会降低其遵守复杂的医疗程序或饮食方案以及充分参与医疗决策的能力。


随着肾功能的降低,患者的认知能力可能也下降,开始透析后认知功能的障碍可能会发生改善,肾移植成功后的患者其认识功能障碍甚至可以出现逆转。

然而,目前关于这些患者的认知功能变化知之甚少,特别是关于不同的治疗方式对认知功能的影响。

为了进一步了解这一点,近期,一篇发表在杂志Kidney int上的文章进行了为期一年的认知功能研究,比较腹膜透析与血液透析患者的认知水平。

在CORETH项目中,研究者们使用两项经过验证的神经认知测试,评估执行功能(Trail Making Test-B)和注意力(d2-Revision-Test)以及自我报告的肾脏生命质量简单认知功能-子量表评估了271名患者在基线和一年后的认知功能。同时对96例血液透析患者和101例腹膜透析患者的倾向评分、适应年龄、合并症、教育和就业情况进行匹配,并调查了时间和治疗方式的影响,控制混杂因素。

最终,一年后,两项测试都显示出了改善。在基线和随访期间,腹膜透析与血液透析相比具有更好的结果,但是两组之间的可比性是有限的。相反的模式适用于自我报告。

更多的血液透析患者排除了认知测试。这些排除患者的增多可能会使调查结果出现偏移,限制了研究结果的普遍性。

此项研究结果表明,腹膜透析可以改善患者的认知功能,并支持此前的研究结论:与血液透析相比,腹膜透析患者在一年的治疗中具有更好的认知功能。

原始出处:
Neumann D, Mau W, et al. Peritoneal dialysis is associated with better cognitive function than hemodialysis over a one-year course. Kidney Int. 2017 Oct 14. pii: S0085-2538(17)30568-9. doi: 10.1016/j.kint.2017.07.022. 

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    2017-10-24 habb
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    2017-10-24 gwc389
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    2017-10-24 xuyong530
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    2017-10-22 天涯183

    非常好的文章.学习了

    0

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