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Exp Cell Res：生物激发生物玻璃/胶原/镁复合材料对骨修复的影响

2019-06-29 不详 网络

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骨骼疾病和骨折影响全世界数百万人。在危急情况下，可能不会发生可能导致不愈合骨折的适当愈合。因此，开发新的临床方法是必要的。在这种背景下，本研究开发了生物玻璃/胶原/镁复合材料，以模仿天然骨骼，增强材料的机械性能，但保持生物玻璃和胶原蛋白的生物活性和性能。因此，本研究旨在利用Wistar大鼠的胫骨缺损，探讨生物玻璃/胶原/镁复合材料对骨修复的生物学效应。将此复合物植入大鼠15和45天后进行组织病理学

骨骼疾病和骨折影响全世界数百万人。在危急情况下，可能不会发生可能导致不愈合骨折的适当愈合。因此，开发新的临床方法是必要的。在这种背景下，本研究开发了生物玻璃/胶原/镁复合材料，以模仿天然骨骼，增强材料的机械性能，但保持生物玻璃和胶原蛋白的生物活性和性能。因此，本研究旨在利用Wistar大鼠的胫骨缺损，探讨生物玻璃/胶原/镁复合材料对骨修复的生物学效应。

将此复合物植入大鼠15和45天后进行组织病理学，形态计量学和免疫组织化学分析以及机械测试。组织病理学评估表明，生物相容性复合材料随着时间的推移而退化，导致从边界到缺损核心的渐进的新骨形成。免疫组织化学显示所有组均提供runx-2和Rank-L免疫染色，与植入后45天的普通生物玻璃相比，生物玻璃/镁组runx-2标记变得明显。胫骨的机械测试表明这些镁基材料具有良好的机械性能，但组间没有发现统计学差异。

总之，应进行额外的研究以确认生物玻璃/胶原/镁对骨修复的结果，使用不同的动物模型和新的平衡量的Mg（3 wt％
原始出处：

Xiao M, Yao B, et al., Stromal-derived Factor-1α signaling is involved in bone morphogenetic protein-2-induced odontogenic differentiation of stem cells from apical papilla via the Smad and Erk signaling pathways. Exp Cell Res. 2019 Aug 1;381(1):39-49. doi: 10.1016/j.yexcr.2019.04.036. Epub 2019 May 7.

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    2020-01-04 ms4964546379600229

    #复合材料#

    0

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    2019-08-02 维他命

    #CEL#

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    2020-05-18 zhaozhouchifen

    #Cell#

    0

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    2019-10-22 axin020

    #骨修复#

    0