Neurology:帕金森病患者视觉和嗅觉交叉模式受损!

2018-02-08 xing.T MedSci原创

由此可见,这些发现表明由于后部壳核缺陷会导致PD患者的视觉/嗅觉的跨模式功能受损。这种交叉模式功能障碍可以作为PD新先兆评估的基础。

近日,神经病学领域权威取杂志Neurology上发表了一篇研究文章,研究人员旨在明确帕金森病(PD)是否会影响视觉和嗅觉的交叉模式功能,因为PD可以损害各种认知功能,包括嗅觉。

研究人员进行了一系列行为实验,通过比较患者和年龄匹配的正常对照者(NCs)的表现来明确PD对交叉模式功能的影响。研究人员通过操纵图片/添味剂之间的语义联系来展示对气味的强度和偏好的视觉效果。此外,研究人员使用脑部成像来确定纹状体突触前多巴胺转运蛋白(DaT)缺失的作用。

进行分析,研究人员发现PD参与者的气味评估不受视觉信息的影响,而NCs在观看愉快/不愉快的视觉线索时,嗅探无味的液体闻出了气味。此外,在DaT缺失的纹状体中,尤其是后部壳核,与PD参与者的较少的视觉效应相关。

由此可见,这些发现表明由于后部壳核缺陷会导致PD患者的视觉/嗅觉的跨模式功能受损。这种交叉模式功能障碍可以作为PD新先兆评估的基础。

原始出处:

Motoyasu Honma,et al. Impairment of cross-modality of vision and olfaction in Parkinson disease.Neurology. 2018. https://doi.org/10.1212/WNL.0000000000005110

本文系梅斯医学(MedSci)原创编译整理,转载需授权!

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=2000308, encodeId=9a9c200030809, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Fri Mar 09 16:27:00 CST 2018, time=2018-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1757415, encodeId=79ce1e574151a, content=<a href='/topic/show?id=058e4852e63' target=_blank style='color:#2F92EE;'>#帕金森病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48527, encryptionId=058e4852e63, topicName=帕金森病患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a17f37322741, createdName=ms6832696159214430, createdTime=Wed May 16 19:27:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481094, encodeId=251214810946a, content=<a href='/topic/show?id=c592908329c' target=_blank style='color:#2F92EE;'>#视觉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90832, encryptionId=c592908329c, topicName=视觉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=adcf7732830, createdName=zywlvao, createdTime=Sat Feb 10 06:27:00 CST 2018, time=2018-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1573928, encodeId=cfb415e3928db, content=<a href='/topic/show?id=6b3348526a0' target=_blank style='color:#2F92EE;'>#帕金森病患#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48526, encryptionId=6b3348526a0, topicName=帕金森病患)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=73fe15977481, createdName=saikp, createdTime=Sat Feb 10 06:27:00 CST 2018, time=2018-02-10, status=1, ipAttribution=)]
    2018-03-09 yinhl1978
  2. [GetPortalCommentsPageByObjectIdResponse(id=2000308, encodeId=9a9c200030809, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Fri Mar 09 16:27:00 CST 2018, time=2018-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1757415, encodeId=79ce1e574151a, content=<a href='/topic/show?id=058e4852e63' target=_blank style='color:#2F92EE;'>#帕金森病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48527, encryptionId=058e4852e63, topicName=帕金森病患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a17f37322741, createdName=ms6832696159214430, createdTime=Wed May 16 19:27:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481094, encodeId=251214810946a, content=<a href='/topic/show?id=c592908329c' target=_blank style='color:#2F92EE;'>#视觉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90832, encryptionId=c592908329c, topicName=视觉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=adcf7732830, createdName=zywlvao, createdTime=Sat Feb 10 06:27:00 CST 2018, time=2018-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1573928, encodeId=cfb415e3928db, content=<a href='/topic/show?id=6b3348526a0' target=_blank style='color:#2F92EE;'>#帕金森病患#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48526, encryptionId=6b3348526a0, topicName=帕金森病患)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=73fe15977481, createdName=saikp, createdTime=Sat Feb 10 06:27:00 CST 2018, time=2018-02-10, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=2000308, encodeId=9a9c200030809, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Fri Mar 09 16:27:00 CST 2018, time=2018-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1757415, encodeId=79ce1e574151a, content=<a href='/topic/show?id=058e4852e63' target=_blank style='color:#2F92EE;'>#帕金森病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48527, encryptionId=058e4852e63, topicName=帕金森病患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a17f37322741, createdName=ms6832696159214430, createdTime=Wed May 16 19:27:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481094, encodeId=251214810946a, content=<a href='/topic/show?id=c592908329c' target=_blank style='color:#2F92EE;'>#视觉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90832, encryptionId=c592908329c, topicName=视觉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=adcf7732830, createdName=zywlvao, createdTime=Sat Feb 10 06:27:00 CST 2018, time=2018-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1573928, encodeId=cfb415e3928db, content=<a href='/topic/show?id=6b3348526a0' target=_blank style='color:#2F92EE;'>#帕金森病患#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48526, encryptionId=6b3348526a0, topicName=帕金森病患)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=73fe15977481, createdName=saikp, createdTime=Sat Feb 10 06:27:00 CST 2018, time=2018-02-10, status=1, ipAttribution=)]
    2018-02-10 zywlvao
  4. [GetPortalCommentsPageByObjectIdResponse(id=2000308, encodeId=9a9c200030809, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Fri Mar 09 16:27:00 CST 2018, time=2018-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1757415, encodeId=79ce1e574151a, content=<a href='/topic/show?id=058e4852e63' target=_blank style='color:#2F92EE;'>#帕金森病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48527, encryptionId=058e4852e63, topicName=帕金森病患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a17f37322741, createdName=ms6832696159214430, createdTime=Wed May 16 19:27:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481094, encodeId=251214810946a, content=<a href='/topic/show?id=c592908329c' target=_blank style='color:#2F92EE;'>#视觉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90832, encryptionId=c592908329c, topicName=视觉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=adcf7732830, createdName=zywlvao, createdTime=Sat Feb 10 06:27:00 CST 2018, time=2018-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1573928, encodeId=cfb415e3928db, content=<a href='/topic/show?id=6b3348526a0' target=_blank style='color:#2F92EE;'>#帕金森病患#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48526, encryptionId=6b3348526a0, topicName=帕金森病患)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=73fe15977481, createdName=saikp, createdTime=Sat Feb 10 06:27:00 CST 2018, time=2018-02-10, status=1, ipAttribution=)]

相关资讯

Lancet Neurol:逾***研究!这项和阿尔兹海默症傻傻分不清的疾病,出基因谱了!

在痴呆综合征的疾病谱中,路易体痴呆( DLB)可以说是最富有临床戏剧特色,最容易被误诊,也是较晚才被单列出来的痴呆类型。近期《柳叶刀神经病学杂志》发表了一篇新研究,揭示了路易体痴呆的基因谱特征!

Sci Transl Med:克罗恩病与帕金森病的共同之处

克罗恩病(Crohn’s disease,CD)是一种炎症性肠病,它在德裔犹太人群 (Ashkenazi Jewish) 中的发病率相对较高。

Gastroenterology:免疫检查点单抗可恢复肝癌细胞肿瘤浸润T细胞功能

,免疫检查点单抗可上调人类肝癌细胞的肿瘤相关抗原特异性T细胞活性,不同作用机制的单抗联用可产生药物联合作用。未来PD-L1, TIM3以及 LAG3单抗有望成为治疗原发性肝癌的利器。

KIDNEY INT:早期腹膜透析可以减轻缺血性急性肾损伤小鼠的肺部炎症!

最近的数据表明在儿童中预防性PD可以减少血清中IL-6水平和改善其结局,本研究的结果与临床高度相关。

Am J Kidney Dis:肥胖对腹膜透析患者寿命、残肾功能、腹膜炎和生存率的影响!

由此可见,肥胖的PD患者比不肥胖的PD患者发生并发症的风险更高,他们的生存率并不劣于匹配的HD患者。

Neurology:长期特发性REM睡眠行为障碍患者的特征

长期原发性REM睡眠行为障碍患者均出现前驱帕金森病症状,这部分患者受到潜在神经退行性过程的影响,对出现长期原发性REM睡眠行为障碍患者应加强早期帕金森干预