Diabetologia：中山大学余学清发现糖尿病视网膜病变或可用于预测糖尿病肾病

2013-09-17 desperado-c dxy

为明确糖尿病视网膜病变在区分非糖尿病肾病与糖尿病肾病中的预测价值，来自中山大学附属第一医院的余学清教授及其团队进行了一项研究（Diabetic retinopathy in predicting diabetic nephropathy in patients with type 2 diabetes and renal disease: a meta-analysis），该研究发现，在2型糖尿病

为明确糖尿病视网膜病变在区分非糖尿病肾病与糖尿病肾病中的预测价值，来自中山大学附属第一医院的余学清教授及其团队进行了一项研究（Diabetic retinopathy in predicting diabetic nephropathy in patients with type 2 diabetes and renal disease: a meta-analysis），该研究发现，在2型糖尿病和肾脏疾病患者中诊断或筛查糖尿病肾病时，糖尿病视网膜病变具有一定的预测价值，增殖性糖尿病视网膜病变可能是糖尿病肾病的一项高度特异性指标。该研究结果发表在2013年3月的Diabetologia杂志上，该杂志影响因子为6.487。【原文下载】

该研究中对Medline和Embase数据库从创立伊始至2012年2月的数据进行检索，入选其中包含糖尿病视网膜病变测量数据的2型糖尿病患者的肾脏活检研究。使用随即效应模型评估其合并敏感性、特异性、阳性预测值、阴性预测值和其他诊断指标。

该项荟萃分析共研究了26篇论文中的2012例患者。研究结果发现，糖尿病视网膜病变预测糖尿病肾病的合并敏感性和特异性分别为0.65和0.75，合并阳性预测值和阴性预测值分别为0.72和0.69。总的受试者工作特征曲线下面积为0.75，诊断比值比为5.67。增殖性糖尿病视网膜病变的合并敏感性为0.25，特异性为0.98。各项研究之间据有异质性，且未确认发表偏倚。

该研究结果表明，在2型糖尿病和肾脏疾病患者中诊断或筛查糖尿病肾病时，糖尿病视网膜病变具有一定的预测价值，增殖性糖尿病视网膜病变可能是糖尿病肾病的一项高度特异性指标。

原文下载

He F, Xia X, Wu XF, Yu XQ, Huang FX.Diabetic retinopathy in predicting diabetic nephropathy in patients with type 2 diabetes and renal disease: a meta-analysis.Diabetologia. 2013 Mar;56(3):457-66.

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2013-12-03 ms9608593228839890

#DIA#

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2014-06-14 ms5439512287675881

#BET#

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2013-09-19 zutt

#视网膜#

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2013-09-19 zhanfl

#视网膜病变#

36 0
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2013-09-19 kalseyzl

#中山大学#

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