SCI REP:孕妇血清25羟维生素D浓度与巨大儿风险!

2018-04-18 xing.T MedSci原创

总之,孕妇血清25(OH)D<50nmol/L与分娩巨大儿有关,应检测孕妇的维生素D缺乏情况。

孕妇维生素D缺乏是否与婴儿出生体重有关仍然存在争论。近日,Scientific reports杂志上发表了一篇研究文章,研究人员进行了一项巢式病例对照研究(545名分娩出巨大儿的女性和1090名对照者)评估了母体血清25羟维生素D [25(OH)D]浓度与巨大儿风险之间的相关性。

研究人员采用酶联免疫法测定了血清25(OH)D浓度,并使用Logistic回归分析、ROC曲线分析和图形图表进行统计分析。

在分娩出巨大儿的妇女中,71.2%的妇女血清25(OH)D浓度<50 nmol/L(P< 0.001),而与对照女性中25(OH)D浓度<50nmol/L的女性为61.1%。对于25(OH)D浓度<50 nmol/L的女性,血清25(OH)D浓度为50-74.9 nmol/L的女性巨大儿风险增加33%,巨大儿风险增加与血清25(OH)D浓度降低呈剂量依赖关系(趋势P=0.001)。研究人员还观察到分娩巨大儿的25(OH)D阈值为50nmol/L,以及25(OH)D浓度对巨大儿的预测精度对应的ROC曲线下面积为0.712。

总之,孕妇血清25(OH)D<50nmol/L与分娩巨大儿有关,应检测孕妇的维生素D缺乏情况。

原始出处:

Juan Wen,et al. Association of maternal serum 25-hydroxyvitamin D concentrations in second and third trimester with risk of macrosomia.Scientific reports.2018. https://www.nature.com/articles/s41598-018-24534-5

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    2018-04-19 小贝熊

    孕妇血清25(OH)D<50nmol/L与分娩巨大儿有关.应检测孕妇的维生素D缺乏情况.

    0

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    2018-04-19 121832a9m88暂无昵称

    学习了

    0

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    2018-04-19 溜溜梅不酸

    孕妇血清25(OH)D<50nmol/L与分娩巨大儿有关.应检测孕妇的维生素D缺乏情况.

    0

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    2018-04-18 惠映实验室

    学习了.谢谢分享.

    0

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