Clin Res Cardiol:有无射血分数保留的HF患者的左心室舒张功能障碍发生率

2021-07-20 MedSci原创 MedSci原创

DD患者有无合并HFpEF与不同的主要心血管危险因素和合并症显著相关

左心室舒张功能障碍 (DD) ,在一般人群中常见,被认为与射血功能保留的心力衰竭 (HFpEF) 相关。在该研究中,Wenzel等评估了在普通人群中年样本中,患有和不患有HFpEF的受试者中DD的患病率及相关性。

在基于人口的Hamburg城市健康研究 (HCHS) 的前10000名受试者中,5913 名受试者(平均64.4 ± 8.3 岁,51.3%为女性)符合当前分析条件。

753名 (12.7%)受试者被发现舒张功能障碍 (DD)。其中,11.2%的患者的DD不合并HFpEF(ALVDD),仅1.3%的患者同时罹患DD和HFpEF(DDwHFpEF)。

基于特定风险因素的ALVDD和DDwHFpEF发生率

在根据主要血管风险因素校正的多变量回归分析中,ALVDD与动脉高血压(OR 2.0, p<0.001)和HbA1c(OR 1.2, p=0.007)有关与ALVDD和DDwHFpEF均相关的因素有:年龄(OR 1.7, p<0.001; OR 2.7, p<0.001)、BMI (OR 1.2, p<0.001; OR 1.6, p=0.001)和左心室质量指数(LVMI)。

与ALVDD和DDwHFpEF相关的因素

相反,女性(OR 2.5,p=0.006)、心房颤动(OR 2.6,p=0.024)、CAD(OR 7.2,p<0.001)、COPD(OR 3.9,p<0.001)和QRS持续时间(OR 1.4, p=0.005)均仅与DDwHFpEF密切相关,但与ALVDD无关。

综上所述,在基于人群的HCHS的前10000名受试者的样本中,DD的患病率为12.7%,其中1.3%的受试者合并HFpEF。DD患者有无合并HFpEF与不同的主要心血管危险因素和合并症显著相关,值得进一步研究它们在ALVDD和DDwHFpEF形成中的可能作用

原始出处:

Wenzel Jan-Per,Kellen Ramona Bei der,Magnussen Christina et al. Diastolic dysfunction in individuals with and without heart failure with preserved ejection fraction.[J] .Clin Res Cardiol, 2021, https://doi.org/10.1007/s00392-021-01907-x

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  5. [GetPortalCommentsPageByObjectIdResponse(id=1826711, encodeId=a7781826e114c, content=<a href='/topic/show?id=e5283e89970' target=_blank style='color:#2F92EE;'>#发生率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37899, encryptionId=e5283e89970, topicName=发生率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Fri Oct 08 07:48:52 CST 2021, time=2021-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1746320, encodeId=aa0f1e4632066, content=<a href='/topic/show?id=699a46801f4' target=_blank style='color:#2F92EE;'>#射血分数保留#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46801, encryptionId=699a46801f4, topicName=射血分数保留)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c84e35706999, createdName=lixiao3338, createdTime=Sat Jan 29 19:48:52 CST 2022, time=2022-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1782137, encodeId=fe411e821374a, content=<a href='/topic/show?id=5db8409ed8' target=_blank style='color:#2F92EE;'>#Cardiol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4097, encryptionId=5db8409ed8, topicName=Cardiol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7532500500, createdName=12499e01m47暂无昵称, createdTime=Mon Nov 08 08:48:52 CST 2021, time=2021-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1667202, encodeId=4939166e2023a, content=<a href='/topic/show?id=53158658854' target=_blank style='color:#2F92EE;'>#舒张功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86588, encryptionId=53158658854, topicName=舒张功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=384626121720, createdName=10518102zz, createdTime=Tue Apr 05 17:48:52 CST 2022, time=2022-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2026171, encodeId=e52020261e19e, content=<a href='/topic/show?id=c2968658593' target=_blank style='color:#2F92EE;'>#舒张功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86585, encryptionId=c2968658593, topicName=舒张功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=52c7237, createdName=yahu, createdTime=Sat Nov 06 12:48:52 CST 2021, time=2021-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1002537, encodeId=dfaf100253ecc, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJHmctib8wsjB1Y0etxU20nsCbR8rZ2fpibp2STmwH2YzicIsTe9oHRGB6XIMeBqNdIvxODicmzfeQibIw/132, createdBy=82211964557, createdName=清幽蓝燕yan, createdTime=Sun Jul 25 19:17:54 CST 2021, time=2021-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1413297, encodeId=8815141329e71, content=<a href='/topic/show?id=1d7e48033f5' target=_blank style='color:#2F92EE;'>#左心室#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48033, encryptionId=1d7e48033f5, topicName=左心室)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=15012955474, createdName=wushaoling, createdTime=Thu Jul 22 13:48:52 CST 2021, time=2021-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421381, encodeId=c444142138116, content=<a href='/topic/show?id=09d33294eb8' target=_blank style='color:#2F92EE;'>#功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32947, encryptionId=09d33294eb8, topicName=功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3493649807, createdName=naiwu78, createdTime=Thu Jul 22 13:48:52 CST 2021, time=2021-07-22, status=1, ipAttribution=)]
    2021-11-06 yahu
  6. [GetPortalCommentsPageByObjectIdResponse(id=1826711, encodeId=a7781826e114c, content=<a href='/topic/show?id=e5283e89970' target=_blank style='color:#2F92EE;'>#发生率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37899, encryptionId=e5283e89970, topicName=发生率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Fri Oct 08 07:48:52 CST 2021, time=2021-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1746320, encodeId=aa0f1e4632066, content=<a href='/topic/show?id=699a46801f4' target=_blank style='color:#2F92EE;'>#射血分数保留#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46801, encryptionId=699a46801f4, topicName=射血分数保留)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c84e35706999, createdName=lixiao3338, createdTime=Sat Jan 29 19:48:52 CST 2022, time=2022-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1782137, encodeId=fe411e821374a, content=<a href='/topic/show?id=5db8409ed8' target=_blank style='color:#2F92EE;'>#Cardiol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4097, encryptionId=5db8409ed8, topicName=Cardiol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7532500500, createdName=12499e01m47暂无昵称, createdTime=Mon Nov 08 08:48:52 CST 2021, time=2021-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1667202, encodeId=4939166e2023a, content=<a href='/topic/show?id=53158658854' target=_blank style='color:#2F92EE;'>#舒张功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86588, encryptionId=53158658854, topicName=舒张功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=384626121720, createdName=10518102zz, createdTime=Tue Apr 05 17:48:52 CST 2022, time=2022-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2026171, encodeId=e52020261e19e, content=<a href='/topic/show?id=c2968658593' target=_blank style='color:#2F92EE;'>#舒张功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86585, encryptionId=c2968658593, topicName=舒张功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=52c7237, createdName=yahu, createdTime=Sat Nov 06 12:48:52 CST 2021, time=2021-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1002537, encodeId=dfaf100253ecc, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJHmctib8wsjB1Y0etxU20nsCbR8rZ2fpibp2STmwH2YzicIsTe9oHRGB6XIMeBqNdIvxODicmzfeQibIw/132, createdBy=82211964557, createdName=清幽蓝燕yan, createdTime=Sun Jul 25 19:17:54 CST 2021, time=2021-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1413297, encodeId=8815141329e71, content=<a href='/topic/show?id=1d7e48033f5' target=_blank style='color:#2F92EE;'>#左心室#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48033, encryptionId=1d7e48033f5, topicName=左心室)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=15012955474, createdName=wushaoling, createdTime=Thu Jul 22 13:48:52 CST 2021, time=2021-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421381, encodeId=c444142138116, content=<a href='/topic/show?id=09d33294eb8' target=_blank style='color:#2F92EE;'>#功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32947, encryptionId=09d33294eb8, topicName=功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3493649807, createdName=naiwu78, createdTime=Thu Jul 22 13:48:52 CST 2021, time=2021-07-22, status=1, ipAttribution=)]
    2021-07-25 清幽蓝燕yan

    学习了

    0

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