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CIRC RES：心肌梗塞后成纤维细胞的来源问题终于有了靠谱的回答！

2017-12-25 MedSci MedSci原创

心血管心肌梗塞
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心肌梗死是全世界范围内导致死亡的主要原因之一。然而，心肌梗死后疤痕组织中的心脏纤维细胞的来源一直存在争议，尤其是很大一部分学者认为骨髓来源的的纤维细胞参与了心肌梗死后疤痕的形成。本研究的目的旨在通过谱系追踪的方法探索梗死心肌的成纤维细胞的来源。本研究利用基因谱系追踪的方法和骨髓移植的方法，均未在永久性左前降支（LAD）冠状动脉结扎术后的心脏中发现骨髓或造血系统来源的表达胶原的成纤维细胞，而心肌梗死

心肌梗死是全世界范围内导致死亡的主要原因之一。然而，心肌梗死后疤痕组织中的心脏纤维细胞的来源一直存在争议，尤其是很大一部分学者认为骨髓来源的的纤维细胞参与了心肌梗死后疤痕的形成。本研究的目的旨在通过谱系追踪的方法探索梗死心肌的成纤维细胞的来源。

本研究利用基因谱系追踪的方法和骨髓移植的方法，均未在永久性左前降支（LAD）冠状动脉结扎术后的心脏中发现骨髓或造血系统来源的表达胶原的成纤维细胞，而心肌梗死区域内的成纤维细胞大部分来源于心外膜。有趣的是，来源于造血系统或者骨髓的成纤维细胞主要分布在梗塞的心外膜表面。

研究结果显示，心肌梗塞后的成纤维细胞大部分来源于心外膜，而非骨髓、内皮-间充质转化或者血液。

原始出处：

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    2018-03-19 ms117281293605716

    #靠谱#

    0

  2. 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    2017-12-31 1209e435m98(暂无昵称)

    学习了.谢谢分享

    0

  3. 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    2017-12-30 虈亣靌

    好资料学习了!

    0

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    2017-12-27 1209e435m98(暂无昵称)

    学习了.谢谢分享

    0

  5. 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    2017-12-27 zhishijing

    #成纤维细胞#

    0

  6. 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    2017-12-27 marongnuan

    #纤维细胞#

    0

  7. 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createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Mon Dec 25 13:12:29 CST 2017, time=2017-12-25, status=1, ipAttribution=)]
    2017-12-26 虈亣靌

    天天学习.努力向上

    0

  8. 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createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Mon Dec 25 14:26:31 CST 2017, time=2017-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272428, encodeId=c7bc2e242824, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Mon Dec 25 13:59:39 CST 2017, time=2017-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272421, encodeId=149d2e242143, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Mon Dec 25 13:12:29 CST 2017, time=2017-12-25, status=1, ipAttribution=)]
    2017-12-25 王秀

    学习了.涨知识了!

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1756658, encodeId=704f1e5665859, content=<a href='/topic/show?id=ba8e99e857c' target=_blank style='color:#2F92EE;'>#靠谱#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99785, encryptionId=ba8e99e857c, topicName=靠谱)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=199a37204836, createdName=ms117281293605716, createdTime=Mon Mar 19 15:02:00 CST 2018, time=2018-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=274150, encodeId=18b62e4150c8, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun Dec 31 11:05:45 CST 2017, time=2017-12-31, status=1, ipAttribution=), 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createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Mon Dec 25 14:26:31 CST 2017, time=2017-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272428, encodeId=c7bc2e242824, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Mon Dec 25 13:59:39 CST 2017, time=2017-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272421, encodeId=149d2e242143, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Mon Dec 25 13:12:29 CST 2017, time=2017-12-25, status=1, ipAttribution=)]
    2017-12-25 orangesking

    好

    0

  10. 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    2017-12-25 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

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