Chest:硬皮病相关的间质性肺疾病的死亡风险预测!

2017-06-23 xing.T MedSci原创

由此可见,SADL模型使用简单,可较好的利用临床变量来预测SCL-ILD患者的全因死亡率。

间质性肺疾病(ILD)是硬皮病(SCL)患者发病率和死亡率的重要原因。由于该疾病在病程中的异质性,SCL-ILD患者的风险预测和预后判断具有挑战性。

研究人员旨在开发一个SCL-ILD的临床死亡预测模型。研究人员从两个正在进行的纵向队列中确定了SCL-ILD患者:加利福尼亚大学医院的135例患者(推导队列)和梅奥诊所的90例患者(验证队列)。利用这两个独立的队列,研究人员开发了一个死亡风险预测模型,并通过测试每一个潜在的候选Cox模型进行验证,每个模型包括19个可能临床预测因子中的3个或4个变量,用于死亡时间。研究人员利用c-指数进行模型识别。

研究人员发现有三个变量被纳入最终的风险预测模型(SADL):既往有吸烟史、年龄、Dlco%-预测。这种连续的模型在推导队列(c-指数=0.88)和验证队列(c-index=0.84)中有类似的表现。研究人员使用组合的队列创建了一个评分系统(c-指数=0.82),并用它来确定三年低、中、高死亡风险的分类。

由此可见,SADL模型使用简单,可较好的利用临床变量来预测SCL-ILD患者的全因死亡率。

原始出处:

Julie Morisset,et al. Mortality risk prediction in scleroderma-related interstitial lung disease: the SADL model.chest.2017. http://journal.publications.chestnet.org/article.aspx?articleid=2634646

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    2017-11-14 Smile2680
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    2017-06-25 rgjl
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    2017-06-23 雾夜芭蕾

    硬皮病相关的间质性肺炎冰冰

    0

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    2017-06-23 1771ae4158m

    学习一下很不错

    0

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