Neurology:增加静脉血栓发生率可能与双氢麦角胺治疗相关!

2017-06-15 xing.T MedSci原创

由此可见,静脉给予双氢麦角胺治疗可能与导管相关的静脉血栓风险增加相关。降低诊断性超声检查的门槛是必要的,因为经常需要抗凝治疗。

近日,神经病学领域权威取杂志Neurology上发表了一篇研究文章,研究人员旨在明确导管相关的静脉血栓发生率在接受静脉注射双氢麦角胺的患者是否高于使用利多卡因的患者。

研究人员采用回顾性方法分析了所有在2008年2月25日至2014年10月31日期间在利福尼亚大学旧金山头痛中心就诊的患者,分析数据包括年龄、性别、诊断、先兆、治疗剂量、所用的静脉通路类型、静脉通路的天数、浅(SVT)或深静脉血栓形成(DVT)和肺栓塞(PE)。

入院就诊的589名患者中有315名(53%)接受了经外周置入中心静脉导管(PICC)或中线导管。平均年龄为38岁,范围从6岁至79岁;121例(21%)患者年龄≤18岁。女性患者占74%(589例中有433例)。263名采用双氢麦角胺的患者使用PICC或中线导管,19名(7.2%)患者发生SVT或DVT或PE;2例患者被诊断为DVT和PE。52名采用利多卡因的患者使用PICC或中线导管,没有血栓事件(P=0.05,Fisher确切检验)。年龄、性别、先兆、总双氢麦角胺剂量以及静脉通路的天数不是静脉血栓的显著预测因素。

由此可见,静脉给予双氢麦角胺治疗可能与导管相关的静脉血栓风险增加相关。降低诊断性超声检查的门槛是必要的,因为经常需要抗凝治疗。

原始出处:

Amy R. Tso,et al. Increased rate of venous thrombosis may be associated with inpatient dihydroergotamine treatment. Neurology. 2017. http://dx.doi.org/10.1212/WNL.0000000000004108

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    2017-08-15 yinhl1978
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    2018-05-21 xue8602
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    2017-12-14 fusion
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    2017-06-15 虈亣靌

    学习了,受益匪浅。

    0

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    2017-06-15 海棠胜雪

    学习了

    0

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