JACC:双重抗血小板治疗评分(DAPT)遭质疑

2018-08-28 MedSci MedSci原创

双重抗血小板治疗(DAPT)评分对冠脉支架植入术后的DAPT及同时存在的缺血和出血风险有指导意义。本研究的目的旨在通过全国范围内的人群评估DAPT评分的表现。本研究纳入了2006年至2014年瑞典国家数据库中的41101名冠脉支架植入后接受有12个月DAPT的患者,并根据DAPT评分对其心梗或支架血栓、主要不良心脑血管事件(MACCE)和大出血事件的风险进行了评估。分析结果显示,心梗或支架血栓的发

双重抗血小板治疗(DAPT)评分对冠脉支架植入术后的DAPT及同时存在的缺血和出血风险有指导意义。本研究的目的旨在通过全国范围内的人群评估DAPT评分的表现。

本研究纳入了2006年至2014年瑞典国家数据库中的41101名冠脉支架植入后接受有12个月DAPT的患者,并根据DAPT评分对其心梗或支架血栓、主要不良心脑血管事件(MACCE)和大出血事件的风险进行了评估。分析结果显示,心梗或支架血栓的发生风险在评分≥3分时明显增高,而MACCE的风险呈J型模式,在评分≥4分时明显增高。缺血和出血事件在高评分(≥2分)和低评分(≤2分)的发生率与DAPT研究中的数据存在差异,大出血事件的发生率约是DAPT研究中的一半。

研究结果显示,DAPT评分并没有很好地区别缺血和出血事件的发生风险,其中出血事件发生风险明显低于DAPT研究中的数据。DAPT评分可能并不适合普遍的人群。

原始出处:

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    2019-04-27 saikp
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    2019-01-15 zhouqu_8
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    2018-08-30 mnda
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    2018-08-29 smartxiuxiu

    有用

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