BMJ:较高的精制谷物摄入增加死亡及主要心血管事件风险

2021-02-05 MedSci原创 MedSci原创

较高的精制谷物摄入量增加参与者死亡率和主要心血管疾病事件的风险

饮食可能影响慢性疾病的发展和进展。在过去几十年里,全球精制谷物和糖消费量有所增加。较高的精制碳水化合物可增加高血糖负担和血管疾病风险。近日研究人员开展PURE研究,考察了精制谷物、全谷物和白米摄入量与心血管疾病、总死亡率、血脂和血压之间的关系
 
 
 
本次研究在21个国家开展,包含148858名参与者,平均随访时间为9.5年。采用国家特定食物频率问卷,用于评估精制谷物、全谷物和白米的摄入量。精制谷物的定义为经过改性以去除麸皮和胚芽的小麦谷物产品或面粉,纤维含量较低。 主要包括白面包、意大利面、早餐谷类食品、饼干和含有精制谷物的烘焙甜点等。全谷物为全麦面粉和含有完整谷物的产品。研究的主要终点为死亡率或主要心血管事件的综合终点,主要心血管事件定义为心血管原因死亡、非致命性心肌梗死、中风或心力衰竭。
 
排除基线心血管疾病患者后,137130名参与者参与研究。在随访期间,9.2%的参与者(n=12668)出现主要终点。与摄入量的最低人群(<50 g/天)相比,精制谷物摄入量最高人群(≥350克/天或约7份/天)的总死亡率(危险比1.27)、主要心血管疾病事件(1.33)及综合终点事件(1.28)风险增加。精制谷物摄入量与收缩压正相关。全谷类或白米的摄入量与终点事件无显著相关性。
 
 
研究认为,较高的精制谷物摄入量增加参与者死亡率和主要心血管疾病事件的风险。
 
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    2021-10-26 gaoxiaoe
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    2021-04-13 licz0435
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