Am J Res Crit Care:睡觉打鼾的2型糖尿病患者更应警惕这一严重并发症!

2017-07-05 枫丹白露 来宝网

由伯明翰大学领导的研究发现,患有2型糖尿病和阻塞性睡眠呼吸暂停症的患者在平均不到4年的时间内就会面临更大的风险,导致失明。



2型糖尿病和睡眠呼吸暂停症并存4年内视力下降显着】由伯明翰大学领导的研究发现,患有2型糖尿病和阻塞性睡眠呼吸暂停症的患者在平均不到4年的时间内就会面临更大的风险,导致失明。

阻塞性睡眠呼吸暂停(OSA)是一种在睡眠期间喉部壁松弛和狭窄的病症,导致打鼾和中断呼吸,并且在2型糖尿病患者中很常见。同时,糖尿病性视网膜病变(糖尿病眼病最常见的形式)影响了40%至50%的糖尿病患者,并且是西方世界失明的主要原因。

以前的研究显示了OSA与糖尿病性视网膜病变之间的联系。然而,在由美国伯明翰大学出版的“美国呼吸和重症医学杂志”发表的研究之前,还没有发表研究评估OSA对2型糖尿病患者糖尿病视网膜病变进程的影响。

伯明翰大学代谢与系统研究所的通讯作者博士Abd Tahrani博士说:“尽管葡萄糖,血压和脂质水平有所改善,但糖尿病性视网膜病变仍然很常见。

“与此同时,OSA已被证明在2型糖尿病患者中非常常见,考虑到多余的重量有助于这两种情况的发展,这并不奇怪。

“然而,大多数患有OSA的患者并没有意识到患有这种疾病,并且该疾病可能未被诊断多年。”

“我们的研究是第一个前瞻性地检查OSA对糖尿病视网膜病变的影响。

“首先,我们显示,与2型糖尿病但没有OSA的患者相比,2型糖尿病和OSA患者的视力威胁性糖尿病性视网膜病变更为常见。

“然而,更重要的是,我们已经表明,OSA和2型糖尿病患者与仅糖尿病患者相比,在三年零七个月的时间里,发生晚期糖尿病视网膜病变的风险增加。”

该研究在米德兰兹的医院的两家糖尿病诊所进行,涉及230例2型糖尿病患者。

该研究排除了任何已知具有OSA或任何类型呼吸道疾病的患者。

使用专门的视网膜成像评估患者的糖尿病视网膜病变,而使用家庭型多通道心肺呼吸便携式装置评估OSA。

结果显示,OSA患者糖尿病视网膜病变患病率(42.9%)高于无OSA患者(24.1%)。

纵向研究发现,随访中,平均43个月后OSA患者(18.4%)较无OSA患者(6.1%)更有可能发展为中度至重度糖尿病性视网膜病变。

同时,该研究还显示,使用连接到面罩的机器接受OSA治疗的患者,其提供压力以防止在睡眠期间阻塞气道的患者与没有接收到的患者相比,发展为晚期糖尿病视网膜病变的风险较低。

Tahrani博士补充说:“我们可以从这项研究得出结论,OSA是2型糖尿病患者进展为中度或重度糖尿病视网膜病变的独立预测因子。

“我们的研究结果很重要,因为对糖尿病性视网膜病变发病机理的了解更为重要,以确定新的治疗方法。

“在我们的研究之后,重要的是治疗2型糖尿病患者的临床医生意识到他们也有OSA的患者特别增加发生晚期视网膜病变的风险,因此应该采取适当的预防措施。

临床医生应考虑测试患者OSA,因为OSA在2型糖尿病患者中非常常见。”

原始出处:

Quratul A Altaf et al. Obstructive Sleep Apnoea and Retinopathy in Patients with Type 2 Diabetes: A Longitudinal Study, American Journal of Respiratory and Critical Care Medicine (2017). DOI: 10.1164/rccm.201701-0175OC.

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    2018-04-19 丁鹏鹏
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    2017-07-07 weiz
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    2017-07-07 tsing_hit
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    2017-07-05 三生有幸9135

    学习一下谢谢分享

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