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SCI REP：糖尿病是慢性丙型肝炎患者发生肝硬化的一个重要危险因素！

2017-08-22 xing.T MedSci原创

糖尿病CHC肝硬化
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总之，糖尿病与CHC患者发生肝硬化的风险增加相关。此外，在CHC和DM的患者中，女性发生肝硬化的风险增加。

近日，Scientific reports 杂志上发表了一篇研究文章，研究人员旨在探讨中国慢性丙型肝炎（CHC）患者糖尿病（DM）和丙型肝炎病毒（HCV）相关的肝硬化风险之间的相关性。

为了评估糖尿病和肝硬化之间的关系，研究人员在210名中国诊断为肝硬化的CHC患者和431名年龄和性别匹配的无肝硬化的CHC患者中进行了一项病例对照研究。

在校正了人口统计学特征和肝硬化的危险因素后，研究人员进行了logistic回归分析，发现糖尿病增加了患肝硬化的风险高达2倍[调整后的比值比（aOR）为2.132；95%可信区间（CI）为1.344-3.382]。此外，肝硬化患者和血清甘油三酯升高（>1.8 mmol/L）的单纯CHC患者的比例分别为5.2%和17.4%，得到的aOR为0.264（95%CI为0.135-0.517）。在糖尿病患者中根据性别分层的HCV相关肝硬化的风险多变量分析显示男性估计的aOR（95%CI）为0.415（0.178-0.969）。

总之，糖尿病与CHC患者发生肝硬化的风险增加相关。此外，在CHC和DM的患者中，女性发生肝硬化的风险增加。

原始出处：

Xu Li,et al. Diabetes mellitus is a significant risk factor for the development of liver cirrhosis in chronic hepatitis C patients.Scientific reports. 2017. https://www.nature.com/articles/s41598-017-09825-7

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    2018-07-04 zjubiostat

    #慢性丙型肝炎#

    0

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    2018-06-26 一叶知秋

    #肝炎患者#

    0

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    2017-08-24 zjubiostat

    #丙型肝炎#

    0

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    2017-08-23 tanxingdoctor

    学习啦!谢谢分享!

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1647896, encodeId=3c5b164e896a7, content=<a href='/topic/show?id=ac125345160' target=_blank style='color:#2F92EE;'>#慢性丙型肝炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53451, encryptionId=ac125345160, topicName=慢性丙型肝炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d24523536533, createdName=zjubiostat, createdTime=Wed Jul 04 12:24:00 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1807826, encodeId=b242180e8264e, content=<a href='/topic/show?id=dd7d8124144' target=_blank style='color:#2F92EE;'>#肝炎患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81241, encryptionId=dd7d8124144, topicName=肝炎患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Tue Jun 26 07:24:00 CST 2018, time=2018-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1274593, encodeId=587612e459397, content=<a href='/topic/show?id=30872089e03' target=_blank style='color:#2F92EE;'>#丙型肝炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20897, encryptionId=30872089e03, topicName=丙型肝炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f503121, createdName=zjubiostat, createdTime=Thu Aug 24 08:24:00 CST 2017, time=2017-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236373, encodeId=28fa2363e36a, content=学习啦!谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Wed Aug 23 14:20:07 CST 2017, time=2017-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236196, encodeId=1aee236196fc, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Wed Aug 23 06:45:48 CST 2017, time=2017-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236108, encodeId=898f23610806, content=继续学习中谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Tue Aug 22 20:57:32 CST 2017, time=2017-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236083, encodeId=a632236083c7, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2emBzjO0FtqTJ05AqrEEdRmp6tmlsLXqpzfxWdtgbbgPGWRHagoK9fLTd3IayRPgkJVIVBWtdlmnkBhOIR4cFM/0, createdBy=e8d51649330, createdName=飘飘爱, createdTime=Tue Aug 22 18:09:11 CST 2017, time=2017-08-22, status=1, ipAttribution=)]
    2017-08-23 130****4638

    学习了受益匪浅

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1647896, encodeId=3c5b164e896a7, content=<a href='/topic/show?id=ac125345160' target=_blank style='color:#2F92EE;'>#慢性丙型肝炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53451, encryptionId=ac125345160, topicName=慢性丙型肝炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d24523536533, createdName=zjubiostat, createdTime=Wed Jul 04 12:24:00 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1807826, encodeId=b242180e8264e, content=<a href='/topic/show?id=dd7d8124144' target=_blank style='color:#2F92EE;'>#肝炎患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81241, encryptionId=dd7d8124144, topicName=肝炎患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Tue Jun 26 07:24:00 CST 2018, time=2018-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1274593, encodeId=587612e459397, content=<a href='/topic/show?id=30872089e03' target=_blank style='color:#2F92EE;'>#丙型肝炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20897, encryptionId=30872089e03, topicName=丙型肝炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f503121, createdName=zjubiostat, createdTime=Thu Aug 24 08:24:00 CST 2017, time=2017-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236373, encodeId=28fa2363e36a, content=学习啦!谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Wed Aug 23 14:20:07 CST 2017, time=2017-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236196, encodeId=1aee236196fc, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Wed Aug 23 06:45:48 CST 2017, time=2017-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236108, encodeId=898f23610806, content=继续学习中谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Tue Aug 22 20:57:32 CST 2017, time=2017-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236083, encodeId=a632236083c7, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2emBzjO0FtqTJ05AqrEEdRmp6tmlsLXqpzfxWdtgbbgPGWRHagoK9fLTd3IayRPgkJVIVBWtdlmnkBhOIR4cFM/0, createdBy=e8d51649330, createdName=飘飘爱, createdTime=Tue Aug 22 18:09:11 CST 2017, time=2017-08-22, status=1, ipAttribution=)]
    2017-08-22 往日如昨

    继续学习中谢谢

    0

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    2017-08-22 飘飘爱

    很好

    0

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