II期临床:白介素23单抗Mirikizumab持续改善克罗恩病患者症状并减少肠道炎症

2020-10-13 MedSci原创 MedSci原创

接受mirikizumab治疗的中度至重度克罗恩病患者,在第52周达到了关键的次要终点。

礼来公司宣布2期SERENITY研究结果,该研究评估了白介素23单抗mirikizumab对中度至重度克罗恩病患者的功效和安全性。

在研究的持续治疗期间,接受mirikizumab治疗的患者在第52周达到了关键的次要终点。结果显示:近60%的患者获得了内镜反应(定义为克罗恩病简化内镜评分[SES-CD]较基线降低至少50%),静脉给药组为58.5%,皮下给药组为58.7%。

超过45%的患者实现PRO缓解(定义为平均每日大便次数≤2.5,腹痛≤1,且不低于基线),静脉给药组为46.3%,皮下给药组为45.6%。

在第12周时获得内镜反应的患者中,静脉给药组(n = 23)和皮下给药组(n = 24)分别有69.6%和66.7%的患者在52周时也有内镜反应。

礼来公司免疫学发展副总裁Lotus Mallbris博士说:“中至重度克罗恩病患者需要更多的治疗选择,有了这些令人鼓舞的2期结果,我们希望继续进行Mirikizumab的临床研究,希望能够为克罗恩氏病患者提供帮助。”

关于Mirikizumab

Mirikizumab是一种人源化IgG4单克隆抗体,与白介素23的P19亚基结合。Mirikizumab正在研究用于治疗多种免疫疾病,包括牛皮癣、溃疡性结肠炎和克罗恩氏病。

关于克罗恩病

克罗恩病是一种可引起全身性炎症的炎症性肠病(IBD),表现为腹痛、腹泻、发烧、体重降低并导致肠梗阻和纤维化等并发症。

原始出处:

https://www.firstwordpharma.com/node/1764463?tsid=4

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createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4gCIdSaEkahCNuUWZv4iaKmqvUKHyKnBiarBM9RStQKBeV5Lh6GYYFiamdV5KlSfbLvmAgZTLtq81XA/0, createdBy=13511650672, createdName=言西早, createdTime=Tue Oct 13 22:56:43 CST 2020, time=2020-10-13, status=1, ipAttribution=)]
    2020-10-17 ms4000000333847907

    0

  5. 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createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4gCIdSaEkahCNuUWZv4iaKmqvUKHyKnBiarBM9RStQKBeV5Lh6GYYFiamdV5KlSfbLvmAgZTLtq81XA/0, createdBy=13511650672, createdName=言西早, createdTime=Tue Oct 13 22:56:43 CST 2020, time=2020-10-13, status=1, ipAttribution=)]
  6. 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createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4gCIdSaEkahCNuUWZv4iaKmqvUKHyKnBiarBM9RStQKBeV5Lh6GYYFiamdV5KlSfbLvmAgZTLtq81XA/0, createdBy=13511650672, createdName=言西早, createdTime=Tue Oct 13 22:56:43 CST 2020, time=2020-10-13, status=1, ipAttribution=)]
  7. 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  8. 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    2020-10-14 Psycho.Dr Du

    CD虽然是慢性炎症性肠病IBD,却有癌变可能,值得重视!#慢性炎症性肠病#

    0

  9. 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    2020-10-13 言西早

    白介素23单抗Mirikizumab持续改善克罗恩病患者症状并减少肠道炎症。

    0

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